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DSC1 Antibody

  • 中文名稱:
    DSC1兔多克隆抗體
  • 貨號:
    CSB-PA007189ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007189ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA007189ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DSC1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DSC1
  • 別名:
    DSC1 antibody; CDHF1 antibody; Desmocollin-1 antibody; Cadherin family member 1 antibody; Desmosomal glycoprotein 2/3 antibody; DG2/DG3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Desmocollin-1 protein (480-690AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
  • 基因功能參考文獻:
    1. DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC. PMID: 27601166
    3. Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases. PMID: 23975055
    4. High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas. PMID: 22438068
    5. The ultrastructural modifications of desmosomes during terminal differentiation of hair follicles are paralleled by the modulation of the synthesis of desmocollin 1. PMID: 15140019
    6. in majority of patients with Netherton syndrome, Dsg1 & Dsc1 were reduced in living layers of epidermis; SCTE-like & SCCE-like activities were increased, suggesting these proteases participate in premature degradation of corneodesmosomal cadherins PMID: 16628198
    7. Increased Dsc1 protein is associated with colorectal cancer PMID: 17088906

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  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 組織特異性:
    Strongly expressed in epidermis, less in lymph node and tongue.
  • 數據庫鏈接:

    HGNC: 3035

    OMIM: 125643

    KEGG: hsa:1823

    STRING: 9606.ENSP00000257198

    UniGene: Hs.567260



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