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DPEP1 Antibody

  • 中文名稱:
    DPEP1兔多克隆抗體
  • 貨號:
    CSB-PA007123LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: HT-29 whole cell lysate, A549 whole cell lysate, U87 whole cell lysate, Hela whole cell lysate
      All lanes: DPEP1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46 kDa
      Observed band size: 46 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA007123LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DPEP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DPEP1
  • 別名:
    Dehydropeptidase-I antibody; Dipeptidase 1 (renal) antibody; Dipeptidase 1 antibody; DPEP1 antibody; DPEP1_HUMAN antibody; hRDP antibody; MBD1 antibody; MDP antibody; Microsomal dipeptidase antibody; RDP antibody; Renal dipeptidase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dipeptidase 1 protein (23-252AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,DPEP1 Antibody (CSB-PA007123LA01HU),的標記方式是Non-conjugated。對于DPEP1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA007123LB01HU DPEP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA007123LC01HU DPEP1 Antibody, FITC conjugated
    Biotin CSB-PA007123LD01HU DPEP1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Antigen Affinity purified & Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics.; Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.
  • 基因功能參考文獻:
    1. The results suggest that DPEP1 promotes cancer metastasis by regulating E-cadherin plasticity and that it might be a potential therapeutic target for preventing the progression of colon cancer. PMID: 26824987
    2. In this study, we present an analysis of Neanderthal introgression at the dipeptidase 1 gene, DPEP1. PMID: 26392408
    3. Dipeptidase 1 has been identified as an excellent marker of high-grade IEN and CRC, and may thus be applied for screening of early neoplastic lesions and for prognostic stratification. PMID: 23839495
    4. DPEP1 plays a role in pancreatic cancer aggressiveness. PMID: 22363658
    5. DPEP1 is expressed in the early stages of colon carcinogenesis and affects cancer cell invasiveness. PMID: 20824289
    6. we identified a novel immunohistochemical marker, dipeptidase 1, to distinguish primary mucinous ovarian cancers from ovarian metastasis of colorectal cancers. PMID: 21076463
    7. Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis PMID: 12144777
    8. DPEP1 has a role in colorectal carcinoma PMID: 15145522

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  • 亞細胞定位:
    Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族:
    Metallo-dependent hydrolases superfamily, Peptidase M19 family
  • 組織特異性:
    Expressed in lung and kidneys.
  • 數據庫鏈接:

    HGNC: 3002

    OMIM: 179780

    KEGG: hsa:1800

    STRING: 9606.ENSP00000261615

    UniGene: Hs.109



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