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  4. DOK5 Antibody

DOK5 Antibody

  • 中文名稱：
    DOK5兔多克隆抗體
  • 貨號：
    CSB-PA030257
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293T cells using Dok-5 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DOK5
  • 別名：
    chromosome 20 open reading frame 180 antibody; Docking protein 5 antibody; DOK 5 antibody; DOK5 antibody; DOK5 protein antibody; DOK5_HUMAN antibody; Downstream of tyrosine kinase 5 antibody; Insulin receptor substrate 6 antibody; IRS-6 antibody; IRS6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Dok-5.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
  • 基因功能參考文獻：
    1. IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis. PMID: 24551065
    2. Although preliminary, these data suggest that DOK5 and perhaps several other genes influence the magnitude of amygdala activation during face processing, particularly in those with BD. PMID: 20215924
    3. identified DOK5 as a novel susceptibility gene for obesity and type 2 diabetes in North Indian subjects PMID: 20187968
    4. DOK5 expression in human T cells, its genomic structure characterized, and its regulation upon T cell activation has been demonstrated. PMID: 12595900
  • 蛋白家族：
    DOK family, Type B subfamily
  • 組織特異性：
    Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
  • 數據庫鏈接：

    HGNC: 16173

    OMIM: 608334

    KEGG: hsa:55816

    STRING: 9606.ENSP00000262593

    UniGene: Hs.473133



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