在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DOK2 Antibody

  • 中文名稱:
    DOK2兔多克隆抗體
  • 貨號(hào):
    CSB-PA070210
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    DOK2
  • 別名:
    Docking protein 2 56kDa antibody; Docking protein 2 antibody; DOK 2 antibody; DOK R antibody; DOK2 antibody; DOK2_HUMAN antibody; Downstream of tyrosine kinase 2 antibody; OTTHUMP00000161710 antibody; OTTHUMP00000224923 antibody; p56(dok 2) antibody; p56(dok-2) antibody; p56dok 2 antibody; p56DOK antibody; p56dok2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from Human Dok-2 around the non-phosphorylation site of Y345.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
  • 基因功能參考文獻(xiàn):
    1. In this report, the authors demonstrated that the cellular adaptor proteins Dok-2 and Dok-1 are tyrosine phosphorylated upon herpes simplex virus 1 infection. In addition, herpes simplex virus 1 induced the selective degradation of Dok-2. Finally, Dok-2 interacts with herpes simplex virus 1 VP11/12, and that herpes simplex virus 1-induced tyrosine phosphorylation and degradation of Dok-2 require VP11/12. PMID: 28841444
    2. DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells. PMID: 27265473
    3. point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB domain PMID: 25252871
    4. Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of natural killer-cell-activating receptors in mouse and human. PMID: 24963146
    5. DOK2 as a tumor suppressor in EGFR-mutant lung adenocarcinoma PMID: 24255704
    6. DOK2 is a marker of poor prognosis in patients with gastric cancer after curative resection PMID: 22130622
    7. Data indicate there was no evidence of DOK2 somatic mutation in the leukemias analyzed. PMID: 21329978
    8. data indicate that DOK2 is altered in gastric (GC) and colorectal cancers (CRC) by loss of expressions; data indicate that somatic mutation of DOK2 may be rare in GC, CRC, breast cancer, prostate cancer and liver cancer PMID: 21749457
    9. Dok1 negatively regulates Dok2-mediated CD200R signaling through the recruitment of CrkL. PMID: 21078907
    10. Identification of DOK genes as lung tumor suppressors. PMID: 20139980
    11. identified tyrosine residue 1106 on Tie2 as an Angiopoietin 1-dependent autophosphorylation site that mediates binding and phosphorylation of the downstream-of-kinase-related (Dok-R) docking protein PMID: 12665569
    12. Dok-R and c-Abl interact in both a constitutive and inducible fashion and Dok-R influences the intracellular kinase and biological activity of c-Abl PMID: 12777393
    13. Dok-2 tyrosine phosphorylation was also found to be involved in collagen receptor, glycoprotein VI (GPVI), signaling as well as in outside-in signaling through the major platelet integrin, alpha IIIb beta 3 PMID: 14645010
    14. DOK1 and DOK2 interact with the Tec protein tyrosine kinase. PMID: 14647425
    15. Dok-R acts as an EGFR-recruited scaffolding molecule that processively assembles c-Src and Csk to attenuate signaling from the EGFR. PMID: 15831486
    16. Phosphotyrosine-binding mediated oligomerization of Dok-1 and Dok-2 represents an essential step for Dok phosphorylation and function. PMID: 16177091
    17. The data provide evidence that DOK2 protein has a role in regulating cell proliferation and differentiation and is positive regulators of the MAPK signaling pathway in this context. PMID: 16823827
    18. Dok-2 is a critical element of a linker for activation of T cells (LAT)-dependent negative feedback loop that attenuates early T-cell receptor (TCR) signal. PMID: 17043143
    19. results demonstrate differential modes of regulation of Dok1 and Dok2 in platelets, and raise the possibility that Dok2 plays an important role in integrin outside-in signaling through a physical and functional interaction with integrin alphaIIbbeta3 PMID: 17092301
    20. Dok-1/Dok-2 pleckstrin homology domains bind in vitro to the rare phosphoinositide species, phosphatidylinositol 5-phosphate PMID: 19299694
    21. CD200R inhibits the activation of human myeloid cells through direct recruitment of Dok2 and subsequent activation of RAS p21 protein activator 1. PMID: 19786546

    顯示更多

    收起更多

  • 蛋白家族:
    DOK family, Type A subfamily
  • 組織特異性:
    Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2991

    OMIM: 604997

    KEGG: hsa:9046

    STRING: 9606.ENSP00000276420

    UniGene: Hs.71215



主站蜘蛛池模板: 成人欧美一区二区三区1314| 狠狠色噜噜狠狠狠888米奇| 久久婷婷香蕉热狠狠综合| 久久精品a亚洲国产v高清不卡 | 亚洲日韩看片无码超清| 一卡二卡3卡四卡网站精品| 99久久国产综合精品麻豆| 精品人妻系列无码人妻免费视频| 丁香五月开心婷婷激情综合| 国产α片免费观看在线人| 亚洲国产精品无码久久久蜜芽| 精品无码国产自产拍在线观看| 国产精品久久久| 亚洲的天堂av无码| 女人和拘做受全程看视频| 成·人免费午夜视频香蕉| 亚洲国产精品热久久| 最近中文2019字幕第二页| 亚洲欧美成人片在线观看| 成人国产一区二区精品小说| 久久av高清无码| 无码精品人妻一区二区三区人妻斩| 久久天天躁狠狠躁夜夜夜| 欧美写真视频在线观看| 国产丰满麻豆videossexhd | 国产精品久久久久久无码五月| 再深点灬舒服灬太大了在线视频| 中文字幕 制服 亚洲 另类| av人摸人人人澡人人超碰小说| 亚洲2020天天堂在线观看| 五月丁香综合激情六月久久| 亚洲色成人网站www永久四虎| 国产成人无码18禁午夜福利网址 | 国产成人免费无庶挡视频| 国产精品免费无码二区| 国产成人av一区二区三区| 无码内射中文字幕岛国片 | 亚洲人成电影网站色www两男一女 国产色xx群视频射精 | 在线成人一区二区| 国产精品不卡无码av在线播放| 日产乱码一二三区别免费麻豆|