在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DOCK8 Antibody

  • 中文名稱:
    DOCK8兔多克隆抗體
  • 貨號:
    CSB-PA836734ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA836734ESR1HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA836734ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DOCK8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DOCK8
  • 別名:
    DOCK8Dedicator of cytokinesis protein 8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dedicator of cytokinesis protein 8 protein (1900-2099AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
  • 基因功能參考文獻:
    1. EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in CD4thorn T cells. PMID: 28067314
    2. A novel DOCK8 sequence insertion caused primary immunodeficiency in two siblings from a consanguineous family. PMID: 26883462
    3. DOCK8 deficiency may present severe immune dysregulation with features that may overlap with those of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and other IPEX-like disorders PMID: 29058101
    4. Recent advances in the understanding of DOCK8 function are summarized, paying particular attention to an emerging role as a signaling intermediate to promote immune responses to diverse external stimuli. [Review] PMID: 28366940
    5. In severe atopic eczema the dermatologist should initially suspect and document a mutation of DOCK8. PMID: 28065530
    6. Our results suggest that decreased expression of DOCK8 in response to CRH might disturb the immunosuppressive function of Tregs and contribute to stress-induced aggravation of AD symptoms. PMID: 26799599
    7. Sequence analysis identified two copies of missense mutation, c.4346C > T, in the coding region of the DOCK8 gene in a family with 3 patients with autosomal recessive Hyper-IgE syndrome. PMID: 27890707
    8. Our results showed that DOCK8-deficient patients have a profound defect in TH17 differentiation related to decreased STAT3 phosphorylation, translocation to the nucleus, and transcriptional activity PMID: 27350570
    9. The CD4+ T-cell compartment is greatly altered in the absence of DOCK8. Specifically, DOCK8-deficient patients have increased TH2 cells and defects in TH1 and TH17 cell differentiation PMID: 27554822
    10. comparative study provides a long-term observation of DOCK8- and STAT3-hyper-IgE syndrome patients with regard to clinical and laboratory findings, and assesses the activation and cytokine secretion of lymphocytes after in vitro stimulation PMID: 26592211
    11. mutations in Chinese patients with hyper-IgE syndrome PMID: 26659092
    12. Letter/Case Report: DOCK8 homozygous mutation leading to primary immune deficiency. PMID: 26235511
    13. DOCK8 deficiency is likely in patients with severe viral infections, allergies, and/or low IgM levels. PMID: 25724123
    14. CD147 has a role in promoting Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells PMID: 25428919
    15. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin. PMID: 25422492
    16. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells PMID: 25218284
    17. Mutations of DOCK8 in three children, two of whom developed sclerosing cholangitis, are reported. PMID: 25220305
    18. Hyper-IgE syndromes and atopic dermatitis patients showed different sensitization pattern of serum IgE corresponding to the allergic disease manifestations and Th-cell subset data, suggesting a key role of DOCK8 in the development of food allergy PMID: 24898675
    19. This is a case of systemic lupus erythematosus with hyper-immunoglobulin E syndrome documented as DOCK8 deficiency. PMID: 25332498
    20. Biallelic mutations in the DOCK8 gene cause autosomal-recessive hyper-IgE syndrome. PMID: 24698323
    21. Two novel large deletions, del1-14 exons and del8-18 exons, of DOCK8 have been identified in two siblings with the adaptive immune deficiencies. PMID: 23859592
    22. DOCK8 is required for the development and survival of mature NKT cells. PMID: 23929855
    23. DOCK8 deficiency results in defective antibody responses and undirected plasma cell expansion in the lymph nodes, as part of a combined immunodeficiency cured by hematopoietic stem cell transplantation. PMID: 23891736
    24. Clinical features of immunodeficiency syndrome are associated with DOCK8 mutations. (Review) PMID: 23911989
    25. We used this new approach to analyse exome data from 24 patients with primary immunodeficiencies. Our analysis identified two novel causative deletions in the genes GATA2 and DOCK8 PMID: 22942019
    26. Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. PMID: 23455509
    27. Three novel DOCK8 mutations and two large deletions are found in thirteen patients with autosomal recessive hyper-IgE syndrome in a single center experience. PMID: 22968740
    28. DOCK8 deficiency results in severely impaired natural killer cell function because of an inability to form a mature lytic immunologic synapse through targeted synaptic F-actin accumulation PMID: 23380217
    29. DOCK8 mediates an MyD88 signaling pathway essential for TLR9-driven B-cell proliferation aand immunoglobulin production. PMID: 22581261
    30. DOCK8 encodes dedicator of cytokinesis 8. PMID: 22876580
    31. DOCK8 deficiency (a newly described combined primary immunodeficiency disease) accounted for 15% of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. PMID: 22534316
    32. Findings help to explain why DOCK8-deficient patients are susceptible to recurrent infections and provide new insights into how T-cell memory is sustained. PMID: 21969276
    33. Rates of malignancy and overall mortality in patients with DOCK8 deficiency were higher than in those with Job's syndrome PMID: 21931011
    34. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 T cells. PMID: 22006977
    35. A 2-bp deletion at codon 510 in exon 14 causing a frameshift mutation was found in 3 homozygous siblings with Job syndrome and their heterozygous first-cousin parents. PMID: 21763205
    36. DOCK8 deficiency and clinical manifestations of hyper IgE syndromes (Review) PMID: 21178271
    37. Mutations in DOCK8 lead to DOCK8 immunodeficiency syndrome characterized by recurrent viral infections, severe atopy, and early onset malignancy. (Review) PMID: 21178272
    38. Several AR-HIES patients have recently been shown to harbour mutations in the gene for dedicator of cytokinesis 8 (DOCK8). Here, we present the long-term outcome of a girl having received a hematopoietic stem cell graft. PMID: 21058221
    39. Autosomal-recessive mutations in DOCK8 are responsible for many, although not all, cases of autosomal-recessive hyper-IgE syndrome. PMID: 20004785
    40. involvement of DOCK8 in processes that affect the organisation of filamentous actin. PMID: 15304341
    41. rare mutations in the DOCK8 gene may contribute to some cases of autosomal dominant mental retardation PMID: 18060736
    42. Under-expression of DOCK8 is associated with hepatocellular carcinoma. PMID: 19640199
    43. Autosomal recessive DOCK8 deficiency is associated with a novel variant of combined immunodeficiency. PMID: 19776401

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal recessive (AR-HIES); Mental retardation, autosomal dominant 2 (MRD2)
  • 亞細胞定位:
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    DOCK family
  • 組織特異性:
    Expressed in peripheral blood mononuclear cells (PBMCs).
  • 數據庫鏈接:

    HGNC: 19191

    OMIM: 243700

    KEGG: hsa:81704

    STRING: 9606.ENSP00000408464

    UniGene: Hs.132599



主站蜘蛛池模板: 国产av国片偷人妻麻豆| 丝袜美腿一区二区三区| 好男人www社区| 国产综合精品久久丫| 女人与公拘交酡全过程| 大胸少妇午夜三级| 色综合中文综合网| 永久免费的无码中文字幕| 免费精品国偷自产在线在线| 日本高清不卡aⅴ免费网站| 99久久人人爽亚洲精品美女| 又粗又大又硬又长又爽| 亚洲 另类 日韩 制服 无码| 国产欧洲精品自在自线官方| 国产又黄又爽胸又大免费视频| 亚洲色成人网一二三区| 狠狠久久噜噜熟女| 国产成人亚洲综合色婷婷秒播| 国产玉足榨精视频在线观看| 欧美一区二区三区久久综合| 日韩精品无码免费一区二区三区| 亚洲精品自产拍在线观看亚瑟| 免费观看的av毛片的网站| 欧洲熟妇色xxxxx欧美老妇伦| 国内久久婷婷五月综合色| 人妻系列无码专区无码中出| 久久国产一区二区三区| 黑巨人与欧美精品一区| 日韩高清在线亚洲专区小说| 极品少妇小泬50pthepon| 国产成人精品午夜福利| 国产人无码a在线西瓜影音| 日韩欧美mv在线观看免费| 色窝窝无码一区二区三区色欲| 国产精品无码永久免费不卡 | 日本丰满熟妇hd| 国产精品久久无码一区二区三区网 | 无码人妻丰满熟妇啪啪网站| 日本妇人成熟免费视频| 日本丰满人妻xxxxxhd| 草草影院发布页|