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  4. DOCK6 Antibody, Biotin conjugated

DOCK6 Antibody, Biotin conjugated

  • 中文名稱：
    DOCK6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA846633LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DOCK6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DOCK6
  • 別名：
    Dedicator of cytokinesis protein 6 antibody; Dock6 antibody; DOCK6_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Dedicator of cytokinesis protein 6 protein (499-616AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth.
  • 基因功能參考文獻：
    1. acute knockdown of the Adams-Oliver syndrome (AOS) gene DOCK6, coding for a RAC1/CDC42 guanine nucleotide exchange factor, results in strikingly different phenotypes to those generated by genomic DOCK6 disruption. PMID: 27693507
    2. this study demonstrates that miR-142-3p is a key regulator of the TGFbeta-mediated contractile phenotype of VSMCs that acts through inhibiting cell migration through targeting DOCK6. PMID: 25832008
    3. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies PMID: 25824905
    4. A homozygous truncating mutation in dedicator of cytokinesis 6 gene (DOCK6) which encodes an atypical guanidine exchange factor (GEF) known to activate two members of the Rho GTPase family: Cdc42 and Rac1, was identified. PMID: 21820096
  • 相關疾病：
    Adams-Oliver syndrome 2 (AOS2)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly located near the cell surface.
  • 蛋白家族：
    DOCK family
  • 組織特異性：
    Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.
  • 數據庫鏈接：

    HGNC: 19189

    OMIM: 614194

    KEGG: hsa:57572

    STRING: 9606.ENSP00000294618

    UniGene: Hs.591002



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