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DOCK10 Antibody

  • 中文名稱:
    DOCK10兔多克隆抗體
  • 貨號:
    CSB-PA842645LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA842645LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DOCK10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DOCK10
  • 別名:
    DOCK10 antibody; KIAA0694 antibody; ZIZ3Dedicator of cytokinesis protein 10 antibody; Zizimin-3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,DOCK10 Antibody (CSB-PA842645LA01HU),的標記方式是Non-conjugated。對于DOCK10 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA842645LB01HU DOCK10 Antibody, HRP conjugated ELISA
    FITC CSB-PA842645LC01HU DOCK10 Antibody, FITC conjugated
    Biotin CSB-PA842645LD01HU DOCK10 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
  • 基因功能參考文獻:
    1. T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms PMID: 21514340
    2. Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells. PMID: 18499258
    3. Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation. PMID: 18835169
  • 亞細胞定位:
    Nucleus. Cytoplasm. Cell projection, dendritic spine.
  • 蛋白家族:
    DOCK family
  • 組織特異性:
    Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
  • 數據庫鏈接:

    HGNC: 23479

    OMIM: 611518

    KEGG: hsa:55619

    STRING: 9606.ENSP00000258390

    UniGene: Hs.46578



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