在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DOCK1 Antibody

  • 中文名稱:
    DOCK1兔多克隆抗體
  • 貨號:
    CSB-PA101358
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA101358(DOCK1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA101358(DOCK1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    180 kDa protein downstream of CRK antibody; Ced5 antibody; Dedicator of Cytokinesis 1 antibody; Dedicator of cytokinesis protein 1 antibody; DOCK 1 antibody; DOCK 180 antibody; DOCK1 antibody; DOCK1_HUMAN antibody; DOCK180 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human DOCK1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
  • 基因功能參考文獻(xiàn):
    1. High DOCK1 expression is associated with Oral squamous cell carcinoma. PMID: 29286141
    2. Dock1 modulation by miR-31 plays an important function in glioma invasion PMID: 26946516
    3. In summary, this investigation identifies an EGFR-DOCK180-RAC1-MLK3-JNK signaling axis that drives glioblastoma cell migration and dissemination.IMPLICATIONS: On the basis of these findings, MLK3 emerges as a potential therapeutic target for the treatment of glioblastoma PMID: 28487380
    4. one statistically significant common variant in the DOCK1 gene was associated with DeltaBMI in GI cancer and COPD cases providing support for at least partially shared aetiology of DeltaBMI in complex diseases. PMID: 28044437
    5. Taken together, these results indicate that DOCK1 is a critical regulator of the malignant phenotypes induced by Rac1(P29S), and suggest that targeting DOCK1 might be an effective approach to treat cancers associated with Rac1(P29S) mutation. PMID: 29432733
    6. Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 and intersectin 1/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 = dedicator of cytokinesis protein 1 180 kDa) PMID: 28600358
    7. stimulation of the DOCK180 pathway represents an alternative mechanism of PTP1B inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 activation as a prerequisite. PMID: 27052191
    8. Thus, Elmo1 and Dock180 facilitate blood vessel formation by stabilization of the endothelium during angiogenesis. PMID: 25586182
    9. High DOCK180 expression is associated with serous ovarian cancer. PMID: 24819662
    10. our findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180 PMID: 23728337
    11. findings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis PMID: 23591873
    12. Dock180 could act as a pro-survival molecule in H9C2 cardiomyocytes via activation of its downstream pro-survival signaling molecule, AKT. PMID: 23314417
    13. Solved is the solution structure of DOCK180 SH3 domain, which shares similar target binding features with the SH3 domain of DOCK2. PMID: 23239367
    14. DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis. PMID: 23592719
    15. Phosphorylation of Dock180(Y1811) enhanced its association with CrkII & p130(Cas). Dock180 associated with PDGFRalpha to promote cell migration. Phosphorylated Dock180(Y1811) contributes to activation of Rac1 in human cancers with PDGFRA amplification. PMID: 22080864
    16. EGFRvIII (also known as DeltaEGFR and de2-7EGFR), a constitutively active EGFR mutant that is frequently co-overexpressed with EGFR in human glioblastoma, promotes tumorigenesis through Src family kinase (SFK)-dependent phosphorylation of Dock180 PMID: 22323579
    17. Dock180 contributes to ovarian carcinogenesis and dissemination PMID: 22175896
    18. DOCK180, an atypical Rac activator, links CXCR4 signaling to Rac activation in order to control endothelial cell migration during cardiovascular development. PMID: 20829512
    19. protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF PMID: 20016009
    20. Dock180 ELMO complex functions as an unconventional two-part exchange factor for Rac. PMID: 12134158
    21. identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity PMID: 12432077
    22. Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 plays a role in cell migration PMID: 14638695
    23. The N-terminal SH3 domain of Dock180 binds to the distant catalytic Docker domain and negatively regulates the function of Dock180. PMID: 15723800
    24. DOCK180, via its DHR-1 and DHR-2 domains, couples PtdIns(3,4,5)P(3) signalling to Rac GTP-loading, which is essential for directional cell movement. PMID: 16025104
    25. ARNO and ARF6 coordinate with the Dock180/Elmo complex to promote Rac activation at the leading edge of migrating cells. PMID: 16213822
    26. The DOCK180 protein is ubiquitylated on the plasma membrane, and also that Elmo1 functions as an inhibitor of ubiquitylation of Dock180. PMID: 16495483
    27. Using pulldown assays, we identified engulfment and cell motility (ELMO) protein as the IpgB1 binding partner. IpgB1 colocalized with ELMO and Dock180 in membrane ruffles induced by Shigella. PMID: 17173036
    28. A significant percentage of the total endogenous Crk II partitions in the nucleus in mammalian cells, where it forms distinct complexes with DOCK180, Wee1, and Abl. PMID: 17764157
    29. DOCK180 regulates CI-MPR trafficking via SNX5 and this function is independent of its guanine nucleotide exchange factor activity toward Rac1 PMID: 18596235
    30. The DOCK180-ELMO1 interaction is mapped to the N-terminal 200 amino acids of DOCK180, and to the C-terminal 200 amino acids of ELMO1, comprising the ELMO1 PH domain. PMID: 18768751
    31. ANKRD28, a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation. PMID: 19118547
    32. It regulates cell morphology and motility. (review) PMID: 19803396

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Membrane.
  • 蛋白家族:
    DOCK family
  • 組織特異性:
    Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2987

    OMIM: 601403

    KEGG: hsa:1793

    STRING: 9606.ENSP00000280333

    UniGene: Hs.159195



主站蜘蛛池模板: 午夜dj高清免费观看视频| 日韩av影院在线观看| 亚洲精品久久久久久无码色欲四季| 狠狠色狠狠人格综合| 国产av无码专区亚洲aⅴ| 狠狠躁夜夜躁人人躁婷婷视频| 亚洲大尺度无码无码专线一区| 成人免费b2b网站大全在线| 宅宅午夜无码一区二区三区| 国产色无码精品视频免费| 亚洲香蕉成人av网站在线观看| 免费1级a做爰片观看| 国产午夜福利精品一区| 成人免费无码大片a毛片户外| 99热在线观看| 国产影片中文字幕| 亚洲大成色www永久网站动图| 成人乱码一区二区三区四区 | 亚洲综合图色40p| 都市激情 在线 亚洲 国产| 久久青青草原精品国产app | 久久久无码精品亚洲日韩按摩| 国产精品天干天干综合网| 亚洲综合小说专区图片| 在线亚洲中文精品第1页| 青青草大香焦在线综合视频 | 无码人妻熟妇av又粗又大| 国产好大好硬好爽免费不卡| 亚洲欧美成人一区二区在线| 四虎影视在线影院在线观看免费视频| 18禁黄污吃奶免费看网站| 色一情一区二| 国产日韩精品视频无码| 国产成人无码一区二区三区| 成人精品视频一区二区三区| 亚洲国产成人超a在线播放| 人妻少妇熟女javhd| 色欲av伊人久久大香线蕉影院| 欧美亚洲国产精品久久| 国产精品调教视频一区| 久久99亚洲精品久久99果|