在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DNASE1L3 Antibody, HRP conjugated

DNASE1L3 Antibody, HRP conjugated

  • 中文名稱：
    DNASE1L3兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA621686EB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DNASE1L3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Deoxyribonuclease gamma antibody; Deoxyribonuclease I like 3 antibody; Deoxyribonuclease I like III antibody; Deoxyribonuclease I-like 3 antibody; DHP 2 antibody; DHP2 antibody; DNAS1L3 antibody; DNase gamma antibody; DNase I homolog protein 2 antibody; DNase I homolog protein DHP2 antibody; DNase I like 3 antibody; DNase I-like 3 antibody; DNASE1L3 antibody; DNSL3_HUMAN antibody; Liver and spleen DNase antibody; LS DNase antibody; LS-DNase antibody; LSD antibody; SLEB 16 antibody; SLEB16 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Deoxyribonuclease gamma protein (21-305AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation.
  • 基因功能參考文獻：
    1. The authors found a significant reduction in serum DNase1l3 level in dermatomyositis/polymyositis and systemic lupus erythematosus, which may associate with clinic features and disease activity. PMID: 28039554
    2. Data indicate a likely functional variant influencing scleroderma susceptibility at deoxyribonuclease I-like 3 protein DNASE1L3 missense polymorphism rs35677470. PMID: 25332064
    3. Single nucleotide polymorphisms in the DNASE1L3 is associated with autoimmune diseases. PMID: 24206041
    4. DNASE1L3 mutations occur in hypocomplementemic urticarial vasculitis syndrome. PMID: 23666765
    5. We identified a rare autosomal recessive form of systemic lupus erythematosus, in which autozygome analysis revealed a null mutation in the DNASE1L3 gene PMID: 22019780
    6. investigates the distribution of DNASE1L3 gene SNPs in exons of the gene in eight Asian, three African, and three Caucasian populations worldwide using newly devised genotyping methods. PMID: 21692081
    7. The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells. PMID: 12154052
    8. Identification of two functional nuclear localization signals in DNase gamma that have a role in apoptotic DNA fragmentation. PMID: 12943533
    9. DNase gamma is involved in the generation of resected double-strand DNA breaks associated with somatic hypermutation PMID: 15629432
    10. DNAS1L3 plays an active role in lymphoma cell sensitization to VP-16 and its deficiency may constitute a novel mechanism of drug resistance in these cells PMID: 16427601
    11. A Caucasian-specific allele in SNP R206C produces an inactive form of DNase Il3. PMID: 19559017
    12. Results distinguish DNase gamma-dependent and CAD/DFF40-dependent DNA fragmentations, and show that even if DNA fragmentation is initiated by CAD/DFF40, DNase gamma is required for the more complete digestion of the genomic DNA in dying cells. PMID: 19574717

    顯示更多

    收起更多

  • 相關疾病：
    Systemic lupus erythematosus 16 (SLEB16)
  • 亞細胞定位：
    Nucleus. Endoplasmic reticulum. Secreted.
  • 蛋白家族：
    DNase I family
  • 組織特異性：
    Liver and spleen.
  • 數據庫鏈接：

    HGNC: 2959

    OMIM: 602244

    KEGG: hsa:1776

    STRING: 9606.ENSP00000316193

    UniGene: Hs.476453



主站蜘蛛池模板： 欧美黑人与白人精品a片| 亚洲aⅴ天堂av天堂无码| 日日日日做夜夜夜夜无码| 又黄又爽的60分钟视频| 内射老阿姨1区2区3区4区| 中文无码乱人伦中文视频在线v| 成人性生交片无码免费看| 无码国产69精品久久久久同性| 18禁勿入午夜网站入口| 女人高潮抽搐潮喷小视频| 人人莫人人擦人人看| 韩国v欧美v亚洲v日本v| 一出一进一爽一粗一大视频| 色综合久久久久无码专区| 欧美又粗又大又黄的片| 亚洲色无码专区在线观看| www夜片内射视频在观看视频| 久在线观看福利视频| 亚洲最大av无码国产| 欧美色欧美亚洲高清在线观看| 亚洲国产精品无码一区二区三区| 毛片无码免费无码播放| 免费99精品国产自在在线| 天堂中文在线资源| 国色天香社区视频手机免费| 国产精品高潮呻吟av久久黄 | 国产成 人 综合 亚洲网站| 精品国偷自产在线视频99| 久久久亚洲精品一区二区三区浴池| 尤物av无码色av无码| 亚洲美女高清无水av| 真实国产乱子伦对白在线播放 | 亚洲综合一区二区三区无码| 欧美成人一区二区三区| 国产公妇仑乱在线观看| 久久www免费人成看片入口 | 无码免费毛片手机在线无卡顿 | 艳妇臀荡乳欲伦交换h在线观看| 亚洲日韩av无码一区二区三区人| 97国语精品自产拍在线观看| 久久996re热这里有精品|