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DNAJC6 Antibody

  • 中文名稱：
    DNAJC6兔多克隆抗體
  • 貨號：
    CSB-PA007040LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007040LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA007040LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA007040LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DNAJC6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DNAJC6 antibody; KIAA0473 antibody; Putative tyrosine-protein phosphatase auxilin antibody; EC 3.1.3.48 antibody; DnaJ homolog subfamily C member 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Putative tyrosine-protein phosphatase auxilin protein (201-500AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DNAJC6 Antibody (CSB-PA007040LA01HU)，的標記方式是Non-conjugated。對于DNAJC6 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA007040LB01HU DNAJC6 Antibody, HRP conjugated ELISA
    FITC CSB-PA007040LC01HU DNAJC6 Antibody, FITC conjugated
    Biotin CSB-PA007040LD01HU DNAJC6 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons.
  • 基因功能參考文獻：
    1. DNAJC6 mutations are not common causes of early onset Parkinson's disease in Chinese population PMID: 27687717
    2. DNAJC6 mutations are associated with early-onset Parkinson's disease. PMID: 26528954
    3. DNAJC6 is up-regulated in hepatocellular carcinoma tissues and up-regulation of DNAJC6 expression predicts poor outcome in patients with HCC PMID: 25446072
    4. Missense mutations in DNAJC6 does not play a major role in PD in the Chinese population. PMID: 24126164
    5. we did not detect any heterozygous or homozygous c.801-2A>G mutation in DNAJC6 in a cohort of Parkinson disease patients from southern Spain. PMID: 24220513
    6. This review presented that DNAJC6 in recessive forms of juvenile parkinsonism. PMID: 24262182
    7. Our findings further establish DNAJC6 as a juvenile parkinsonism gene, and expand the spectrums of the parkinsonism phenotype and DNAJC6 mutation PMID: 23211418
    8. study reports a homozygous mutation in DNAJC6 in two patients with autosomal-recessive juvenile Parkinsonism; the mutation was associated with abnormal transcripts and marked reduced DNAJC6 mRNA level PMID: 22563501
    9. The DNAJC6 gene encodes auxilin-1, a protein required for clathrin-dependent recycling of synaptic vesicles in neurons that is possibly at the origin of the mental retardation and epilepsy phenotype PMID: 22647716
    10. there are two auxilins with overlapping functions; they not only facilitate the uncoating of clathrin-coated vesicles but also prevent the formation of nonproductive clathrin cages in the cytosol PMID: 18489706

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  • 相關疾?。?/div>
    Parkinson disease 19A, juvenile-onset (PARK19A); Parkinson disease 19B, early-onset (PARK19B)
  • 組織特異性：
    Expressed in various brain regions, including cerebellum, corpus callosum, cortex, striatum, brainstem, pons, putamen, spinal cord and substantia nigra. Very low expression in non-neural tissues such as leukocytes, liver, adipose tissue, skeletal muscle a
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15469

    OMIM: 608375

    KEGG: hsa:9829

    STRING: 9606.ENSP00000378735

    UniGene: Hs.647643



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