在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DNAJC5 Antibody

  • 中文名稱:
    DNAJC5兔多克隆抗體
  • 貨號:
    CSB-PA001802
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of LOVO cells using CSP Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CLN 4 antibody; CLN4 antibody; CLN4B antibody; CSP antibody; cysteine string protein alpha antibody; Cysteine string protein antibody; DJC5 antibody; DnaJ (Hsp40) homolog subfamily C member 5 antibody; DnaJ homolog subfamily C member 5 antibody; DNAJC 5 antibody; Dnajc5 antibody; DNAJC5A antibody; DNJC5_HUMAN antibody; NCL antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human CSP.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.
  • 基因功能參考文獻:
    1. Results indicate that by assisting local lysosome/proteasome processes, CSPalpha-mediated removal of toxic proteins via extracellular vesicles plays a central role in synaptic proteostasis. PMID: 28424476
    2. The importance of specific residues in the cysteine-string domain was investigated, revealing that a central core of palmitoylated cysteines is essential for aggregation of adult-onset neuronal ceroid lipofuscinosis CSPalpha L115R/L116 mutants. PMID: 28127059
    3. Phosphorylation of CSP triggers a major conformational switch that modulates its protein interactions. PMID: 27452402
    4. In fact, DnaJC5 overexpression induced tau release in cells, neurons, and brain tissue, but only when activity of the chaperone Hsc70 was intact and when tau was able to associate with this chaperone. PMID: 27261198
    5. This study demonstrated that Neuronal ceroid lipofuscinosis with DNAJC5/CSPalpha mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. PMID: 26659577
    6. These results suggest that the degeneration seen in the patients with AD-ANCL reported here might be a consequence of both the early effects of CSPalpha mutations at the cellular soma. PMID: 26610600
    7. the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease. PMID: 25631211
    8. Missense mutations in DNAJC5 does not play a major role in PD in the Chinese population. PMID: 24126164
    9. Results indicate of a p.L116del mutation in DNAJC5 from families with autosomal dominant Kufs disease. PMID: 22978711
    10. Palmitoylation-induced aggregation of mutant CSP-alpha proteins may underlie the development of adult-onset neuronal ceroid lipofuscinosis PMID: 22902780
    11. association of DNAJC5 mutations with autosomal dominant Kufs disease PMID: 22235333
    12. This is the first replication study of the identification of DNAJC5 as the disease-causing gene for autosomal dominant ANCL. The identification of the novel gene in ANCL will allow us to gain a better understanding of the pathological mechanism of ANCLs PMID: 22073189
    13. A neuroprotective role for CSPalpha in humans is confirmed. PMID: 21820099
    14. First evidence that CSP and HSP70, and their interactions with MARCKS, are involved in mucin secretion from airway epithelium. PMID: 18314541
    15. Csp not only regulates the exit of CFTR from the ER, but this action is accompanied by Hsc70/Hsp70 and CHIP-mediated CFTR degradation. PMID: 19098309
    16. Csp has a role in regulated CFTR trafficking at the plasma membrane. [CYSTEINE STRING PROTEIN] PMID: 12039948
    17. Cysteine string protein inhibits N-type calcium channels, but is blocked by mutant huntingtin PMID: 14570907
    18. CSP modulates G protein function by preferentially targeting the inactive GDP-bound form of G alpha(s) and promoting GDP/GTP exchange; the guanine nucleotide exchange activity of full-length CSP is regulated by Hsc70-SGT PMID: 15972823
    19. Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis PMID: 16469739
    20. palmitoylation of CSP is enhanced specifically by co-expression of the Golgi-localized palmitoyl transferases DHHC3, DHHC7, DHHC15, or DHHC17 PMID: 18596047
    21. Has a role in exocytosis of large dense core vesicles. PMID: 10194413

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Ceroid lipofuscinosis, neuronal, 4B (CLN4B)
  • 亞細胞定位:
    Cytoplasm, cytosol. Membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane. Melanosome. Cell membrane.
  • 組織特異性:
    Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
  • 數據庫鏈接:

    HGNC: 16235

    OMIM: 162350

    KEGG: hsa:80331

    STRING: 9606.ENSP00000354111

    UniGene: Hs.164419



主站蜘蛛池模板: 黑人巨茎大战欧美白妇免费| 亚洲男人a在天堂线一区| 丰满多毛少妇做爰视频爽爽和| av人摸人人人澡人人超碰下载| 久久久久无码国产精品一区| 欧美性受xxxx黑人xyx性爽 | 扒开双腿疯狂进出爽爽爽视频 | 国产精品点击进入在线影院高清 | 无码专区aaaaaa免费视频| 亚洲系列一区中文字幕| 十八禁视频在线观看免费无码无遮挡骂过| 成 人影片 aⅴ毛片免费观看| 国产精品国产三级国产专区53| 99蜜桃臀久久久欧美精品网站| 亚洲第一成年免费网站| 国产午夜无码片在线观看网站| 国产精品久久久久久人妻| 伊人久久无码中文字幕| 无码午夜成人1000部免费视频| 久久伊99综合婷婷久久伊| 国产v亚洲v天堂a无码99| 久久大香国产成人av| 又大又粗弄得我出好多水| 另类 专区 欧美 制服| 色综合天天无码网站| 精品午夜中文字幕熟女人妻在线| 欧美老熟妇乱子| 韩国精品一区二区无码视频| 日韩精品中文字幕无码一区 | 骚虎成人免费99xx| 裸身美女无遮挡永久免费视频| 亚洲精品久久久久久| 亚洲粉嫩高潮的18p| 成人免费无码视频在线网站| 国产av人人夜夜澡人人爽麻豆| 国产精品久久久久久久| 亚洲国产欧美在线人成人| 日本乱码一区二区三区不卡| 国产精品久久国产精品99| 337p人体粉嫩胞高清视频| 亚洲国产精品一区二区动图|