在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DNAJC3 Antibody, Biotin conjugated

DNAJC3 Antibody, Biotin conjugated

  • 中文名稱(chēng)：
    DNAJC3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA615670LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) DNAJC3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DnaJ (Hsp40) homolog subfamily C member 3 antibody; DnaJ homolog subfamily C member 3 antibody; DNAJC3 antibody; DNJC3_HUMAN antibody; double-stranded RNA-activated protein kinase inhibitor antibody; Endoplasmic reticulum DnaJ protein 6 antibody; ERdj6 antibody; HP58 antibody; Interferon induced; double stranded RNA activated protein kinase inhibitor antibody; Interferon-induced antibody; P58 antibody; p58 ipk antibody; P58IPK antibody; PRKRI antibody; Protein kinase inhibitor of 58 kDa antibody; Protein kinase inhibitor p58 antibody; Protein kinase interferon inducible double stranded RNA dependent inhibitor antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human DnaJ homolog subfamily C member 3 protein (277-496AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
  • 基因功能參考文獻(xiàn)：
    1. DNAJC3 p.H238N is likely to be a variant causing diabetes. PMID: 29767246
    2. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis PMID: 25329545
    3. Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans. PMID: 25466870
    4. p58(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K/Akt pathway that requires activation of ATF6a and subsequently upregulates mitofusin 2. PMID: 24134518
    5. interplay between p38 phosphorylation and p58(IPK) upregulation has key roles in modulating ERp29-induced cell-growth arrest and survival PMID: 22064321
    6. the crystal structure of human P58(IPK) PMID: 21799829
    7. Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. PMID: 20554776
    8. Spleen cells from transgenic mice overexpressing (Hu)PKR were studied and compared to those from wild-type mice after drug treatment. Dact-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division. PMID: 12034040
    9. P58(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha signaling, and thus attenuate the unfolded protein response. PMID: 12601012
    10. The study demonstrates that P58(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells. PMID: 18568130

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus (ACPHD)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum.
  • 組織特異性：
    Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9439

    OMIM: 601184

    KEGG: hsa:5611

    STRING: 9606.ENSP00000365991

    UniGene: Hs.59214



主站蜘蛛池模板： 野狼第一精品社区| 妓院一钑片免看黄大片| 2020精品国产自在现线看 | 秋霞av在线露丝片av无码| 女人夜夜春高潮爽a∨片| 国产精品成人一区二区三区| 亚洲欧洲日产国码无码久久99| 国精品无码一区二区三区在线| 末发育女av片一区二区| 英语老师丝袜娇喘好爽视频| 免费国偷自产拍精品视频| 97影院理论片手机在线观看| 久久精品人人爽人人爽| 国产拍揄自揄精品视频| аⅴ资源中文在线天堂| 亚洲 激情 小说 另类 欧美| 自拍偷亚洲产在线观看| 久久久久av无码免费网| 亚洲熟女乱色综合亚洲图片| 中文字幕三级人妻无码视频| 成人免费无码不卡毛片视频| 少妇大叫太大太爽受不了| 人妻丰满熟妇aⅴ无码| 久久伊人精品波多野结衣| 久久婷婷色综合老司机| 色妺妺视频网| 亚洲人av高清无码| 麻豆精产一二三产区| 亚洲一线二线三线品牌精华液久久久| 搡老女人老妇女老熟妇| 免费无遮挡无码视频网站| 日韩人妻潮喷中文在线视频| 麻豆国产av超爽剧情系列| 国产精品视频免费播放| 亚洲精品国产综合久久一线| 国产婷婷综合在线视频| 国产自偷自偷免费一区| 国产熟妇午夜精品aaa| 欧美乱人伦视频在线| 国产精品美女久久久网站 | 天堂在线www资源|