在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DNAJC3 Antibody, Biotin conjugated

DNAJC3 Antibody, Biotin conjugated

  • 中文名稱(chēng)：
    DNAJC3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA615670LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) DNAJC3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DnaJ (Hsp40) homolog subfamily C member 3 antibody; DnaJ homolog subfamily C member 3 antibody; DNAJC3 antibody; DNJC3_HUMAN antibody; double-stranded RNA-activated protein kinase inhibitor antibody; Endoplasmic reticulum DnaJ protein 6 antibody; ERdj6 antibody; HP58 antibody; Interferon induced; double stranded RNA activated protein kinase inhibitor antibody; Interferon-induced antibody; P58 antibody; p58 ipk antibody; P58IPK antibody; PRKRI antibody; Protein kinase inhibitor of 58 kDa antibody; Protein kinase inhibitor p58 antibody; Protein kinase interferon inducible double stranded RNA dependent inhibitor antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human DnaJ homolog subfamily C member 3 protein (277-496AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
  • 基因功能參考文獻(xiàn)：
    1. DNAJC3 p.H238N is likely to be a variant causing diabetes. PMID: 29767246
    2. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis PMID: 25329545
    3. Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans. PMID: 25466870
    4. p58(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K/Akt pathway that requires activation of ATF6a and subsequently upregulates mitofusin 2. PMID: 24134518
    5. interplay between p38 phosphorylation and p58(IPK) upregulation has key roles in modulating ERp29-induced cell-growth arrest and survival PMID: 22064321
    6. the crystal structure of human P58(IPK) PMID: 21799829
    7. Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. PMID: 20554776
    8. Spleen cells from transgenic mice overexpressing (Hu)PKR were studied and compared to those from wild-type mice after drug treatment. Dact-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division. PMID: 12034040
    9. P58(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha signaling, and thus attenuate the unfolded protein response. PMID: 12601012
    10. The study demonstrates that P58(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells. PMID: 18568130

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus (ACPHD)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum.
  • 組織特異性：
    Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9439

    OMIM: 601184

    KEGG: hsa:5611

    STRING: 9606.ENSP00000365991

    UniGene: Hs.59214



主站蜘蛛池模板： 综合无码成人aⅴ视频在线观看| 999国产精品999久久久久久| 亚洲成色在线综合网站| 久久婷婷国产剧情内射白浆| 人妻熟妇乱又伦精品视频无广告| 激情人妻另类人妻伦| 人妻丝袜中文无码av影音先锋专区| 午夜免费啪视频在线18| 亚洲制服 视频在线观看| 色哟哟最新在线观看入口| 99精品欧美一区二区三区| 噜噜色综合噜噜色噜噜色| 久久婷婷丁香七月色综合| 日本肉体裸xxxxbbbb| 黑人巨大精品欧美黑寡妇| 无码人妻久久一区二区三区不卡| 国产免费又色又爽又黄软件| 免费的污污的网站在线观看| 欧美一进一出抽搐大尺度视频| 国产乱人无码伦av在线a | 国产成人精品高清在线观看99| 天堂在/线中文在线资源8| 欧美在线精彩视频免费播放| 久久这里只有精品首页 | 日本乱妇乱子视频网站-百度 | 精品国产福利一区二区| 亚洲国产成人无码电影| 国色天香中文字幕在线视频| 久久精品国产精品亚洲下载| 天天天天噜在线视频| 内射精品无码中文字幕| 蜜桃av色偷偷av老熟女| 亚洲成本人无码薄码区| 极品少妇高潮到爽| 国产区女主播在线观看| 国产高潮又爽又刺激的视频| 国产成人国产在线观看| 妺妺窝人体色www看美女| 久久五月丁香激情综合| 成人福利国产精品视频| 久久精品aⅴ无码中文字字幕重口|