在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DNAJB12 Antibody

DNAJB12 Antibody

  • 中文名稱：
    DNAJB12兔多克隆抗體
  • 貨號：
    CSB-PA007005GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DNAJB12; DnaJ homolog subfamily B member 12
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DNAJB12
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear.; (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection.
  • 基因功能參考文獻：
    1. ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG K+ channels. They regulate two distinct aspects of K+ channel biogenesis, the stabilization and assembly of channel subunits. PMID: 27916661
    2. Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 = DnaJ (Hsp40) homolog, subfamily B, member 12) PMID: 28536268
    3. Over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous structures within cell nuclei, designated DJANGOS for DNAJ-associated nuclear globular structures. PMID: 24732912
    4. JB12 cooperates with cytosolic Hsc70 and the ubiquitin ligase RMA1 to target CFTR and CFTRDeltaF508 for degradation. PMID: 21148293
    5. DNAJB12 is a novel mammalian ER-localized J-protein that plays a vital role in the quality control of membrane proteins PMID: 21150129

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
  • 蛋白家族：
    DnaJ family, DNAJB12/DNAJB14 subfamily
  • 數據庫鏈接：

    HGNC: 14891

    OMIM: 608376

    KEGG: hsa:54788

    STRING: 9606.ENSP00000345575

    UniGene: Hs.500013



主站蜘蛛池模板： 黄网站色视频免费国产| 国产真人做爰毛片视频直播| 人禽无码视频在线观看| 免费人成视频网站在线观看18| 人人澡人人澡人人看添| 亚洲精品久久久久久中文| 久久精品中文字幕| 免费无码午夜福利片| 日日碰狠狠添天天爽超碰97| 国产3p露脸普通话对白| 一本加勒比hezyo无码资源网| 色多多www视频在线观看免费| 日日摸日日碰夜夜爽无码| 麻豆果冻传媒2021精品传媒一区| 亚洲综合伊人久久大杳蕉| 国产成人无码性教育视频| 亚洲中文字幕婷婷在线| 国产内射xxxxx在线| 久久久成人毛片无码| 久久伊人色av天堂九九| 两性色午夜视频免费播放| 无码国产精品成人| 狠狠色噜噜狠狠狠7777奇米| 亚洲国产精品成人天堂| 亚洲经典国产精华液单品榜| 在线天堂资源www中文| 亚洲精品乱码久久久久久金桔影视| 无码少妇精品一区二区免费动态| 欧美另类又黄又爽的a片| 人妻少妇av中文字幕乱码| 成人欧美一区二区三区1314| 欧美成aⅴ人高清怡红院 | 中文字幕欧美亚州视频免费 | 国产精品自在拍一区二区不卡| 国产日韩在线时看高清视频| 久久99精品国产.久久久久| 野花在线无码视频在线播放| 国产欧美精品一区二区色综合| 推油少妇久久99久久99久久| 亚洲一卡2卡3卡4卡国产| 免费国产在线精品一区二区三区|