在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DNAJA3 Antibody

  • 中文名稱:
    DNAJA3兔多克隆抗體
  • 貨號:
    CSB-PA793564
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA793564(DNAJA3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA793564(DNAJA3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DNAJA3
  • 別名:
    DNAJA3 antibody; HCA57 antibody; TID1DnaJ homolog subfamily A member 3 antibody; mitochondrial antibody; DnaJ protein Tid-1 antibody; hTid-1 antibody; Hepatocellular carcinoma-associated antigen 57 antibody; Tumorous imaginal discs protein Tid56 homolog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Full length fusion protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
  • 基因功能參考文獻:
    1. Impaired stoichiometry between mtHsp40 and mtHsp70 promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function. PMID: 25904328
    2. The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-kappaB Signaling. PMID: 26245905
    3. TID1 prevents complex I aggregation and support the existence of a TID1-mediated stress response to ATP synthase inhibition PMID: 24492964
    4. Tid1 acts as a tumor suppressor by inhibiting EGFR signaling through interaction with EGFR/HSP70/HSP90 and enhancing EGFR ubiquitinylation and degradation. PMID: 23698466
    5. Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1)-depedendent mitochondrial fragmentation and decreased cell viability. PMID: 22595283
    6. loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin PMID: 22692211
    7. Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 protein, and that both are significant prognostic indicators of breast cancer patient survival. PMID: 21710689
    8. findings denote hTid-1(S) as an essential regulatory component of MetR signaling PMID: 21242965
    9. hTid1 negatively regulates the expression and transcriptional activity of STAT5b and suppresses the growth of hematopoietic cells transformed by an oncogenic form of STAT5b. PMID: 21106534
    10. htid is a tissue independent and evolutionarily conserved suppressor of ErbB-2. PMID: 20565727
    11. amino-terminal segment of APC promotes cell sensitivity to apoptosis modulated through its binding to 40- and 43-kilodalton hTID-1 isoforms. PMID: 19900451
    12. role as a repressor of Ikappa B kinase beta subunit PMID: 11927590
    13. Tid-1S in Th2 cells following activation has a role in induction of apoptosis resistance during the activation of Th2 cells PMID: 12879007
    14. an important cell death regulator and could exert tumor suppressor activity PMID: 15156195
    15. findings suggest that the status of hTid-1 in gliomas may contribute to their susceptibility to cell death triggers PMID: 15589840
    16. hTid-1 represses the activity of NF-kappaB through physical and functional interactions with the IKK complex and IkappaB PMID: 15601829
    17. the carboxyl-terminal end of TID1 (residues 224-429) bound to Trk at the activation loop (Tyr(P)(683)-Tyr(684)(P)(684) PMID: 15753086
    18. Tid1 is critical for the transition of double-negative to double-positive cells in early T cell development through modulation of antiapoptotic bcl-2 expression. PMID: 15879105
    19. Tid1 negatively regulates the motility and metastasis of breast cancer cells, most likely through attenuation of nuclear factor kappaB activity on the promoter of the IL8 gene. PMID: 16204048
    20. hTid1 may act as a chaperone to facilitate the folding, processing and maturation of Epstein-Barr virus-encoded BARF1 protein. PMID: 16518412
    21. The association of Tid1 with chaperones and/or protein substrates in the cytosol provides a mechanism for the alternate fates and functions of Tid1 in mitochondrial and nonmitochondrial pathways. PMID: 16531398
    22. The association of the endogenous Tid50/Tid48 proteins with the adenomatous polyposis coli (APC) tumor suppressor is shown. PMID: 17588722
    23. The expression of the genes htid-1 and APC was altered in colorectal tumors. PMID: 18097612

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein.
  • 組織特異性:
    Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
  • 數據庫鏈接:

    HGNC: 11808

    OMIM: 608382

    KEGG: hsa:9093

    STRING: 9606.ENSP00000262375

    UniGene: Hs.459779



主站蜘蛛池模板: 图片区小说区亚洲欧美自拍| 无码中文av有码中文av| 欧美熟妇丰满肥白大屁股免费视频| 免费国产成人高清在线观看网站| 好爽太紧了舒服视频| 婷婷五月综合色中文字幕| 久久中文字幕无码专区| 丰满女人又爽又紧又丰满| 国产无遮挡a片又黄又爽| 精品国产乱码久久久久app下载| 国产麻豆精品传媒av国产婷婷| 久久综合九色综合欧洲98| 国产精品成人一区二区三区| 又粗又大内射免费视频小说| 国产色产综合色产在线视频| 国产做a爰片久久毛片a片白丝| av无码人妻中文字幕| 国产成人涩涩涩视频在线观看 | 5566先锋影音夜色资源站在线观看 | 97久久精品无码一区二区天美| 天天躁夜夜踩很很踩2022| 久久99精品久久久久久清纯| 亚洲精品久久久一区| 5个黑人躁我一个视频| 天堂国产一区二区三区| 亚洲国产天堂久久久久久| 国产精品久久人妻互换| 久久人妻少妇嫩草av| 国产精品视频免费播放| 丰满大爆乳波霸奶| 末发育娇小性色xxxxx| 成人免费无码大片a毛片小说 | 国产精品黄页免费高清在线观看| 国产精品55夜色66夜色| 中文字幕被公侵犯的漂亮人妻| 亚洲欧美日韩综合一区| 久久久久77777人人人人人| 中文人妻无码一区二区三区在线| 亚洲人成欧美中文字幕| 免费无码又爽又刺激高潮 | 久青草影院在线观看国产|