在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DNAAF4 Antibody, HRP conjugated

  • 中文名稱:
    DNAAF4兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA855504LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) DNAAF4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DNAAF4
  • 別名:
    Dyslexia susceptibility 1 candidate 1 antibody; Dyslexia susceptibility 1 candidate gene 1 protein antibody; DYX1 antibody; DYX1C1 antibody; DYXC1 antibody; DYXC1_HUMAN antibody; EKN1 antibody; FLJ37882 antibody; MGC70618 antibody; RD antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Dynein assembly factor 4, axonemal protein (109-295AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.
  • 基因功能參考文獻(xiàn):
    1. that endogenous DYX1C1 localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium PMID: 27451412
    2. promoter SNP rs12899331 of DYX1C1 may contribute towards the manifestation of DD. This study supports the association of DYX1C1 with DD in an Indian population PMID: 24362368
    3. results demonstrate that DYX1C1 can modulate the expression of genes involved in cell migration and nervous system development and associates with a number of cytoskeletal proteins. PMID: 23036959
    4. DYX1C1 is required for axonemal dynein assembly and ciliary motility. PMID: 23872636
    5. The results of this study do not provide evidence for association between the putatively functional single nucleotide polymorphisms -3G/A and 1249G/T in DYX1C1 and reading disabilities. PMID: 23341075
    6. Gene-by-environment effects were found between some specified environmental moderators (i.e. maternal smoke during pregnancy, birth weight and socio-economic status) and the DYX1C1-1259C/G marker PMID: 23176554
    7. results suggested that the 931C > T variant in KIAA0319, but not the -3G > A in DYX1C1, was significantly associated with the risk of dyslexia PMID: 23065966
    8. DYX1C1 influences reading development in the general Chinese population and supports a universal effect of this gene. PMID: 23028439
    9. The results of this study found that DYX1C1 gene contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. PMID: 22683091
    10. Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia. PMID: 22558177
    11. the expression of DYX1C1 in breast cancer is associated with several clinicopathological parameters and that loss of DYX1C1 correlates with a more aggressive disease, in turn indicating that DYX1C1 is a potential prognostic biomarker in breast cancer. PMID: 22375924
    12. A single nucleotide polymorphism previously shown to be associated with dyslexia and located in the cis-regulatory region of DYX1C1 may alter the epigenetic and endocrine regulation of this gene. PMID: 22383464
    13. findings suggest that DYX1C1 is associated with dyslexia in people of Chinese ethnicity. PMID: 21599957
    14. No statistically significant associations were found between DCDC2 or DYX1C1 and language phenotypes. Both DCDC2 and DYX1C1 DD susceptibility genes appear to have a pleiotropic role on mathematics but not language phenotypes. PMID: 21046216
    15. At this point, there is no statistical evidence of association between the allelic variation in the three candidate genes and DD in our sample. PMID: 21203818
    16. Association signals were detected for several single nucleotide polymorphisms within DYX1C1 with both the reading and spelling tests PMID: 20846247
    17. Results suggest that DYX1C1 influences reading and spelling ability with additional effects on short-term information storage or rehearsal. Missense mutation rs17819126 is a potential functional basis for the association of DYX1C1 with dyslexia. PMID: 19901951
    18. Functional characterization of the homologous rat protein. PMID: 16989952
    19. DYX1C1 should be regarded as a candidate gene for developmental dyslexia and localizes to a fraction of cortical neurons and white matter glial cells PMID: 12954984
    20. Findings provide support for EKN1 as a risk locus for dyslexia and as contributing to reading component processes and reading-related abilities. PMID: 15249932
    21. Thus it seems unlikely that DYX1C1 gene would be involved in the genetic etiology of autism in Finnish patients. PMID: 15470369
    22. DYX1C1 is unlikely to be a susceptibility gene for developmental dyslexia PMID: 15477871
    23. Single nucleotide polymorphisms of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs. PMID: 15520411
    24. disequilibrium with DYX1C1 is more saliently explained in Italian dyslexics by short-term memory PMID: 17309662
    25. The observation of weak evidence for transmission disequilibrium for one of the two studied polymorphisms in DYX1C1 suggests involvement of this gene in dyslexia. PMID: 17450541
    26. TFII-I, PARP1, and SFPQ proteins, each previously implicated in gene regulation, form a complex controlling transcription of DYX1C1. Allelic differences in the promoter or 5'UTR of DYX1C1 may affect factor binding and thus regulation of the gene. PMID: 18445785
    27. Alternatively spliced transcript variants of the DYX1C1 gene may be used as cancer biomarkers to detect colorectal cancer. PMID: 18618141
    28. The contribution of DYX1C1 to dyslexia in a sample of 366 trios of German descent, was investigated. PMID: 19240663
    29. The DYX1C1 is a novel Hsp70 and Hsp90-interacting co-chaperone protein and its expression is associated with malignancy. PMID: 19277710
    30. DYX1C1 interacts with both ERs in the presence of 17beta-estradiol in neurons. PMID: 19423554

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Dyslexia 1 (DYX1); Ciliary dyskinesia, primary, 25 (CILD25)
  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm. Dynein axonemal particle. Cell projection, neuron projection.
  • 組織特異性:
    Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 21493

    OMIM: 127700

    KEGG: hsa:161582

    STRING: 9606.ENSP00000323275

    UniGene: Hs.126403



主站蜘蛛池模板: 亚洲成av人片在线观看无| 午夜精品乱人伦小说区| 国产一卡2卡3卡4卡网站精品| 妺妺窝人体色www婷婷| 精品一区二区三区免费播放| а√8天堂中文官网资源| 少妇午夜福利一区二区| 大肉大捧一进一出好爽视频动漫| 精品亚洲一区二区三区在线播放| 国产超碰无码最新上传| 欧美另类又黄又爽的a片| 丝袜高潮流白浆潮喷在线播放 | 国产freexxxx性播放麻豆| 亚洲午夜av久久久精品影院| 色偷一区国产精品| 午夜精品电影你懂的| 久久久噜噜噜久久熟女| 亚洲综合另类小说专区| 特黄熟妇丰满人妻无码| 综合无码一区二区三区| 亚洲aⅴ综合色区无码一区| 亚洲精品久久久久久久久久久捆绑| 国产午夜不卡片免费视频| 中文字幕av一区| 欧美又大又硬又粗bbbbb| 久久精品国产精品青草| av天堂中av世界中文在线播放| 久久不见久久见免费视频1′| 成人免费无码大片a毛片抽搐| 忍不住的亲子中文字幕| 久久久亚洲欧洲日产国码606| 久久精品国产欧美日韩99热 | 最新精品露脸国产在线| 婷婷丁香六月激情综合啪| 久久免费看少妇高潮v片特黄| 久久欧美国产伦子伦精品| 最新的国产成人精品2021| 国内精品久久久久久无码| 少妇愉情理伦片bd| 国产丰满麻豆videossexhd | 香蕉视频在线精品视频|