在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DNA2 Antibody

  • 中文名稱:
    DNA2兔多克隆抗體
  • 貨號:
    CSB-PA006982LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006982LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA006982LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DNA2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DNA replication ATP-dependent helicase-like homolog antibody; DNA replication helicase 2 homolog antibody; DNA replication helicase 2, yeast, homolog of antibody; DNA replication helicase 2-like antibody; DNA replication helicase/nuclease 2 antibody; DNA2 antibody; DNA2-like helicase antibody; DNA2L antibody; DNA2L_HUMAN antibody; HDNA2 antibody; KIAA0083 antibody; PEOA6 antibody; SCKL8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DNA replication ATP-dependent helicase/nuclease DNA2 protein (1-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,DNA2 Antibody (CSB-PA006982LA01HU),的標記方式是Non-conjugated。對于DNA2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA006982LB01HU DNA2 Antibody, HRP conjugated ELISA
    FITC CSB-PA006982LC01HU DNA2 Antibody, FITC conjugated
    Biotin CSB-PA006982LD01HU DNA2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
  • 基因功能參考文獻:
    1. This review mainly encompasses the key functions of DNA2 in human cells with various aspects, especially focusing on the genome integrity, and also generalizes the recent insights to the mechanisms related to the occurrence of cancer and other diseases potentially linked to the mutations in DNA2. PMID: 28903076
    2. The authors show that the helicase of hDNA2 functionally integrates with BLM or WRN helicases to promote double-stranded DNA degradation by forming a heterodimeric molecular machine. This collectively suggests that the human DNA2 motor promotes the enzyme's capacity to degrade double-stranded DNA in conjunction with BLM or WRN and thus promote the repair of broken DNA. PMID: 27612385
    3. the motor of DNA2 functions as a ssDNA translocase to promote degradation of 5'-terminated DNA. PMID: 28336515
    4. The suppression of FANCD2(-/-) by DNA2 knockdowns suggests that DNA2 and FANCD2 also have antagonistic roles: in the absence of FANCD2, DNA2 somehow corrupts repair. PMID: 24626199
    5. BRCA1 and CtIP contribute to DSB resection by recruiting Dna2 to damage sites, thus ensuring the robust DSB resection necessary for efficient homologous recombination. PMID: 25909997
    6. depletion of DNA2 in cells reduces proliferation, addition of estrogen restores proliferation. cells responding to estrogen will proliferate despite impaired in DNA2 activity, potentially promoting genomic instability and triggering cancer development. PMID: 25238049
    7. EXO1, MRE11, and CtIP are not involved in the same mechanism of reversed fork processing, whereas human RECQ1 limits DNA2 activity by preventing extensive nascent strand degradation. PMID: 25733713
    8. DNA2 stimulates the helicase activity of BLM. PMID: 25200081
    9. WRN and BLM act epistatically with DNA2 to promote the long-range resection of double strand break ends in human cells. PMID: 25122754
    10. DNA2 interacts with FANCD2, and cisplatin induces FANCD2 ubiquitylation even in the absence of DNA2. PMID: 22987153
    11. These results implicate human DNA2 and the long-patch base-excision repair pathway in the pathogenesis of adult-onset disorders of mtDNA maintenance. PMID: 23352259
    12. A characterization of the substrate specificities influencing hDna2 binding and cleavage functions and the sequential interaction of hFEN1 and hDna2 on Okazaki fragment intermediates. PMID: 22570407
    13. analysis of Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication PMID: 22570476
    14. reviews the evidence for the dynamic design of Okazaki fragment processing and the roles of Dna2 and its interacting partners in carrying out this design. [REVIEW] PMID: 20131965
    15. Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates. PMID: 20019387
    16. The purified human Dna2 enzyme contains intrinsic endonuclease and DNA-dependent ATPase activities, but is devoid of detectable DNA helicase activity. PMID: 16595799
    17. hDna2 showed ATPase/helicase activity and 5'-3' exo-endonuclease as well as 3'-5' exo-endonuclease activity, indicating that its biochemical properties are very similar to yeast DNA2. PMID: 16595800
    18. report here two novel activities of both the yeast and human Dna2 helicase/nuclease protein: single strand annealing and ATP-independent strand exchange on short duplexes PMID: 17032657
    19. Replication protein A stimulates the 5'- to 3'-nuclease activity of Dna2 and inhibits the 3'- to 5'-exo/endonuclease activity of Dna2. PMID: 18593712
    20. studies illustrate an evolutionarily diversified role of hDNA2 in mitochondrial DNA replication and repair in a mammalian system. PMID: 18995831
    21. Data indicate that hDna2 is similar to its yeast counterpart and is a new addition to the growing list of proteins that participate in both nuclear and mitochondrial DNA maintenance. PMID: 19487465

    顯示更多

    收起更多

  • 相關疾病:
    Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 6 (PEOA6); Seckel syndrome 8 (SCKL8)
  • 亞細胞定位:
    Nucleus. Mitochondrion.
  • 蛋白家族:
    DNA2/NAM7 helicase family
  • 數據庫鏈接:

    HGNC: 2939

    OMIM: 601810

    KEGG: hsa:1763

    STRING: 9606.ENSP00000382133

    UniGene: Hs.532446



主站蜘蛛池模板: 日本熟妇厨房bbw| 麻豆精产一二三产区| 无码精品日韩中文字幕| 麻豆果冻精东九一传媒mv| 欧美丰满熟妇xxxx性ppx人| 欧美怡红院免费全部视频| 尹人香蕉久久99天天拍久女久| 国产亚洲中文日本不卡二区| 天堂√在线中文最新版| 裸身美女无遮挡永久免费视频 | 国模冰莲极品自慰人体| 欧美巨大xxxx做受高清| 国产成人无码精品久久涩吧| 日韩精品射精管理在线观看| 狼色精品人妻在线视频| 99久久精品国产成人综合| 中文国产成人精品久久久| 色欲av亚洲一区无码少妇| 香港三日本8a三级少妇三级99 | 国产免费网站看v片在线无遮挡| 国产精品麻豆欧美日韩ww| 久久精品无码一区二区日韩av| 国产杨幂丝袜av在线播放| 波多野结衣初尝黑人| 东京热一区二区三区无码视频| 日韩乱码在线观看免费视频网站| 97久久超碰中文字幕| 中文字幕人妻熟女在线| 亚洲乱亚洲乱妇中文影视| 国产亚洲综合欧美视频| 婷婷色五月开心五月| 无码人妻少妇伦在线电影| 中文字幕第一区高清av| 天堂网在线www资源| 特级毛片内射www无码| а√中文在线资源库| 国产人妻久久精品二区三区| 亚洲最大成人av在线天堂网| 7777久久亚洲中文字幕| 亚洲国产剧情中文视频在线| 欧美真人做爰在线观看|