在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DMTN Antibody

DMTN Antibody

  • 中文名稱：
    DMTN兔多克隆抗體
  • 貨號：
    CSB-PA002115
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using Dematin Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DMTN
  • 別名：
    DEMA antibody; DEMA_HUMAN antibody; Dematin antibody; DMT antibody; EPB49 antibody; erythrocyte membrane protein band 4.9 (dematin) antibody; Erythrocyte membrane protein band 4.9 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human Dematin around the non-phosphorylation site of S403.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
  • 基因功能參考文獻：
    1. When unphosphorylated, dematin's two F-actin binding domains move independent of one another permitting them to bind different F-actin filaments. PMID: 23355471
    2. the headpiece domain of dematin regulates calcium mobilization and signaling in platelets PMID: 23060452
    3. a novel functional role for dematin in regulating erythrocyte membrane function. PMID: 22927433
    4. Fast backbone dynamics probed at amide nitrogen versus carbonyl carbon sites for dematin headpiece C-terminal. The reduction of mobility in the loop region upon the S74E mutation can be seen from the (15)N order parameters. PMID: 20396930
    5. results suggest that phosphorylation of the dematin headpiece acts as a conformational switch within this headpiece domain PMID: 14660664
    6. a crucial role for this proline residue in structural stability and folding potential of HP (sub)domains consistent with Pro-Trp stacking as a more general determinant of protein stability PMID: 16697408
    7. study investigated motions in the backbone of dematin headpiece domain and its mutant DHPS74E using several complementary NMR relaxation techniques PMID: 19030997
    8. results suggest that the core domain of dematin exhibits properties typical of a natively unfolded protein, while the headpiece domain is folded in a conformation essentially identical to its native structure PMID: 19241372

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development.
  • 蛋白家族：
    Villin/gelsolin family
  • 組織特異性：
    Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.
  • 數據庫鏈接：

    HGNC: 3382

    OMIM: 125305

    KEGG: hsa:2039

    STRING: 9606.ENSP00000265800

    UniGene: Hs.106124



主站蜘蛛池模板： 国产成 人 综合 亚洲专区| 少妇被粗大的猛烈进出视频| 少妇被躁爽到高潮无码久久| 三级视频兔费看| av亚欧洲日产国码无码| 国产精品国产对白熟妇| 潮喷无码正在播放| 香蕉久久精品日日躁夜夜躁夏| 日本体内she精高潮| 国产精品99久久免费| 2020年无码国产精品高清免费| 69久久精品无码一区二区无码| 精品久久久久久久无码| 伊人久久久精品区aaa片| 又黄又爽又色视频免费| 国产精品亚洲精品一区二区| 黑人巨大av在线播放无码| 色综合久久一区二区三区| 香蕉久久久久久av成人| 无码人妻精品中文字幕不卡| 人妻少妇久久精品电影| 国产18禁黄网站免费观看| 人妻丰满熟妇aⅴ无码| 国产精品99久久精品| 色老头精品午夜福利视频| 都市激综合小说区另类区| 午夜精品久久久久久久| 九九综合九色综合网站| 久久人午夜亚洲精品无码区| 成人午夜精品无码一区二区三区| 亚洲国产精品成人午夜在线观看| 噜噜色综合噜噜色噜噜色| 2020最新无码国产在线观看| 国产成人精品一区二区秒播 | 国产精品久久久久久无码五月| 亚洲va综合va国产产va中| 粉嫩av久久一区二区三区| _97夜夜澡人人爽人人喊_欧美| 性欧美丰满熟妇xxxx性5| 熟妇高潮精品一区二区三区| 日韩视频在线观看|