在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DLX5 Antibody

  • 中文名稱:
    DLX5兔多克隆抗體
  • 貨號:
    CSB-PA571618
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, 293 cells and COLO205 cells, using DLX5 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using DLX5 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DLX5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human DLX5.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
  • 基因功能參考文獻:
    1. Our results in mice suggest that long-range DLX5 enhancer elements located in the human SLC25A13 gene may underlie the sensorineural hearing loss that is sometimes associated with SHFM1. PMID: 29301908
    2. These results indicate activation of DLX5 and RUNX2 via its distal promoter represents a unique feature of GFs, and is important for ECM regulation. Down-regulation of these transcription factors in PAFs could be associated with their property to degrade collagen, which may impact on the process of periodontitis. PMID: 27645561
    3. these findings indicate that, in MSCs, DLX5 is a master regulator of osteogenesis. Furthermore, tanshinone IIA may be valuable for stem cell-based therapies of certain bone diseases. PMID: 28949384
    4. As a result of disturbed imprinting, the upregulated DLX5 affects trophoblast proliferation in preeclampsia. PMID: 28904069
    5. These data indicate that certain missense mutations diminish the ability of the Dlx5 homeodomain to recognize and bind target DNAs, and they likely destabilize the formation of functional complexes. PMID: 26829219
    6. In cells grown on titanium support, DLX5 and RUNX1 were respectively upregulated (+3.12-fold) and downregulated (-2.14-fold) PMID: 25025858
    7. Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I. PMID: 25332435
    8. Heterozygous DLX5 nonsense mutation c.G115T(p.E39X) associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated Polish families. PMID: 25196357
    9. A novel heterozygous mutation in exon 3 of DLX5 found in the family members with SHFM1 phenotype. PMID: 24496061
    10. Genome sequencing of the deletion breakpoints showed that the DLX5 and DLX6 genes are disomic but the putative DYNC1I1 exon 15 and 17 enhancers are deleted. PMID: 24459211
    11. The duplicated region harbors only DLX5 and DLX6, which are known for their role in SHFM1. PMID: 23169702
    12. The strongest evidence for altered methylation patterns in shiftworkers was observed for DLX5 gene. PMID: 23193016
    13. Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression. PMID: 22332551
    14. Two patients that have in common a p63-Dlx5/Dlx6 pathway dysregulation. PMID: 22342398
    15. the first intragenic DLX5 mutation in split hand and foot malformation is found; a potential dual role for DLX5 in limb development is suggested PMID: 22121204
    16. DLX5 is significantly increased in heart tissue from calcific aortic valve patients compared to controls. PMID: 21205918
    17. MDA-MB-231 breast neoplasms did not express DLX5 but the resulting bone/lung metastases did. PMID: 21108812
    18. Data suggest that DLX5 plays a significant role in the pathogenesis of some ovarian cancers by enhancing IRS-2-AKT signaling. PMID: 21045156
    19. p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development. PMID: 20808887
    20. Results describe the expression of DLX5 and DLX6 in autistic spectrum disorder patients in an attempt to identify potential abnormality of expression. PMID: 19195802
    21. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. PMID: 11959851
    22. DLX5 was confirmed to be imprinted in normal human lymphoblasts and brain tissues by a polymorphic analysis PMID: 12782124
    23. DLX5 is a target for MeCP2, linking genomic imprinting and Rett syndrome [review] PMID: 15954098
    24. In dental follicle cells, gene expression of runx2, DLX-5, and MSX-2 was unaffected during osteogenic differentiation in vitro. PMID: 16467978
    25. high expression of mutated MECP2 in TRD mutation showed bialleic expression of DLX5 suggesting loss of imprinting PMID: 17363207
    26. DLX5 and DLX6 are not imprinted in humans and are not likely to be direct targets of MeCP2 modulation. PMID: 17701895
    27. Dlx5 can act as an oncogene by cooperating with Akt2 to promote lymphomagenesis PMID: 18316591
    28. Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients. PMID: 18413826
    29. The MYC promoter is specifically activated by overexpression of DLX5. PMID: 19497851
    30. Dlxin-1 binds Dlx5 and several additional homeodomain proteins and may regulate the function of Dlx family members in bone formation PMID: 11084035

    顯示更多

    收起更多

  • 相關疾病:
    Split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive (SHFM1D)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Distal-less homeobox family
  • 數據庫鏈接:

    HGNC: 2918

    OMIM: 220600

    KEGG: hsa:1749

    STRING: 9606.ENSP00000222598

    UniGene: Hs.99348



主站蜘蛛池模板: 国产精品交换| 久久av高潮av无码av| 国产亚洲精品在av| 99精品久久毛片a片| 成熟丰满熟妇高潮xxxxx视频| 国内久久婷婷五月综合色| 欧美人与禽zozzo性伦交| 欧美性受xxxxzooz乱毛| 中文字幕精品久久久久人妻红杏1 久久久精品日本一区二区三区 | 亚洲另类欧美综合在线 | 东京热无码国产精品| 影音先锋每日av色资源站| 亚洲日韩乱码一区二区三区四区| 精品三级av无码一区| 欧洲熟妇色xxxxx视频| 2021最新国产精品网站| 亚洲一区av无码专区在线观看| 中文天堂在线www| 日韩高清亚洲日韩精品一区| 不卡av中文字幕手机看| 一个人看的免费高清www视频| 日韩人妻一区二区三区免费 | 人妻免费一区二区三区最新| 9久9久女女热精品视频在线观看 | 国产精品边做奶水狂喷无码| 国产超级va在线观看视频| 日本人妻巨大乳挤奶水| 国产午夜无码精品免费看| 中文字幕人妻a片免费看| 夜夜高潮夜夜爽高清视频| 久久久国产乱子伦精品作者| 伊人www22综合色| 国产成人无码av片在线观看不卡| 国内自拍久久久久影院| 无码人妻少妇色欲av一区二区| 黄瓜视频在线观看| av在线 高清不卡区| 8x国产精品视频| 亚洲中文字幕无码中文字在线| 丰满人妻一区二区三区无码av| 天堂网www天堂资源网|