在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DLX2 Antibody

  • 中文名稱:
    DLX2兔多克隆抗體
  • 貨號:
    CSB-PA006953DSR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA006953DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006953DSR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) DLX2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DLX2
  • 別名:
    DII A antibody; Distal less homeo box 2 antibody; Distal less homeobox 2 antibody; DLX 2 antibody; Dlx2 antibody; DLX2_HUMAN antibody; Dlx5 antibody; Homeobox protein DLX 2 antibody; Homeobox protein DLX-2 antibody; Homeobox protein DLX2 antibody; Homeobox protein TES 1 antibody; Homeobox protein TES1 antibody; Tes 1 antibody; Tes1 antibody; zgc antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Homeobox protein DLX-2 protein (1-140AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
  • 基因功能參考文獻(xiàn):
    1. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis. PMID: 29242628
    2. Authors characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of glioma-initiating cells. PMID: 28459464
    3. DLX2 is a novel marker of poor prognosis and sorafenib resistance in patients with hepatocellular carcinoma. PMID: 27302463
    4. High Ki67 expression is only present in 6.8% of CaP patients and is predictive of reduced survival and increased risk of metastasis, independent of PSA, Gleason score and D'Amico risk category. DLX2 is a novel marker of increased metastasis risk found in 73% patients and 8.2% showed co-expression with a high Ki67 score PMID: 27336609
    5. High DLX-2 expression is associated with epithelial-mesenchymal transition in cancer. PMID: 26771232
    6. DLX2 plays a crucial role in radioresistance, radiation-induced epithelial to mesenchymal transition and cancer stem cell marker expression, and the expression of DLX2 is regulated by Smad2/3 signaling in A549 and MDA-MB-231 cell lines. PMID: 26799321
    7. DLX2 expression reduces the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK family kinase, leading to reduced ATM-p53 signaling and senescence bypass PMID: 26833729
    8. Results showed that Dlx-2 is involved in TGF-beta- and Wnt-induced epithelial-mesenchymal transition, glycolytic switch, and mitochondrial repression by Snail activation. PMID: 25651912
    9. The activation of DLX2 signaling might improve tissue regeneration mediated by MSCs of dental origin. Results provide insight into the mechanism underlying the directed differentiation of MSCs of dental origin. PMID: 24756434
    10. Increased expression of DLX2 may correlate with the advanced stage of gastric adenocarcinoma, and it may contribute to tumor development. PMID: 23674878
    11. overexpression of DLX2 indicated poor survival in the 83 glioblastoma multiforme patients PMID: 23331016
    12. Dlx2 (and Dlx1) are required to generate cortical interneurons in the medial ganglionic eminence. PMID: 23312518
    13. Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis PMID: 21917150
    14. MDA-MB-231 breast neoplasms expressed DLX2. PMID: 21108812
    15. In corroboration with paired-like homeodomain protein 2 (PITX2) protein kinase C functional studies, a newly identified carboxyl-terminal PITX2 mutation associated with Axenfeld-Rieger syndrome demonstrates reduced phosphorylation. PMID: 15751970
    16. In mice, biological and biochemical observations suggest that functional antagonism through heterodimer formation is a mechanism for regulating the transcriptional actions of Msx and Dlx homeoproteins. PMID: 9111364
    17. results in mutated mice suggest that Dlx2 controls development of branchial arches and the forebrian, suggesting a role in craniofacil evolution PMID: 7590232
    18. provides the sequence of human DLX2 and compares it to the murine gene. PMID: 8812481
    19. In mice osteoblasts, both Dlx2 and Dlx5 are coordinately induced by BMP2 as early as 30 minutes into their growth and differentiation. PMID: 12957859

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    Distal-less homeobox family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2915

    OMIM: 126255

    KEGG: hsa:1746

    STRING: 9606.ENSP00000234198

    UniGene: Hs.419



主站蜘蛛池模板: 老头把我添高潮了a片| 男女一边摸一边做爽爽| 九九九免费观看视频| 成年无码av片在线| 99re6热视频这里只精品首页| 国产成人a人亚洲精品无码| 午夜福利无遮挡十八禁视频| 不卡av中文字幕手机看| 久久久久久好爽爽久久 | 国产精品久久久久久无码五月| 免费无码成人av在线播放不卡| 日本二区三区欧美亚洲国| 无遮挡1000部拍拍拍免费| 97人妻人人揉人人躁人人| 亚洲乱亚洲乱妇中文影视| 又湿又紧又大又爽又a视频| 开心色怡人综合网站| 国产99久久精品一区二区| 色狠狠成人综合网| 人妻人人澡人人添人人爽| 欧美国产日韩a在线观看| 人人爽天天碰狠狠添| 成人一区二区免费视频| 色婷婷久久综合中文久久蜜桃av| 亚洲a片国产av一区无码| 亚洲成片在线观看12345| 五月天精品视频在线观看| 女厕偷窥一区二区三区| 成人伊人亚洲人综合网站| 麻豆人妻无码性色av专区| 国产99久久久欧美黑人刘玥| 人人澡人人透人人爽| 精品av国产一二三四区| 无码精品a∨在线观看十八禁| 性开放的欧美大片| 亚洲已满18点击进入在线看片| 亚洲аv电影天堂网| 丁香狠狠色婷婷久久综合| 国产精品一区二区av在线观看| 含紧一点h边做边走动免费视频| 成年午夜精品久久久精品|