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DIRAS1 Antibody

  • 中文名稱:
    DIRAS1兔多克隆抗體
  • 貨號:
    CSB-PA002151
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HepG2 cells using Di-Ras1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DIRAS1
  • 別名:
    DIRAS1 antibody; GBTS1 antibody; RIGGTP-binding protein Di-Ras1 antibody; Distinct subgroup of the Ras family member 1 antibody; Ras-related inhibitor of cell growth antibody; Rig antibody; Small GTP-binding tumor suppressor 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human Di-Ras1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Displays low GTPase activity and exists predominantly in the GTP-bound form.
  • 基因功能參考文獻:
    1. This neuronal DIRAS1 gene with a proposed role in cholinergic transmission provides not only a candidate for human myoclonic epilepsy but also insights into the disease etiology, while establishing a spontaneous model for future intervention studies and functional characterization. PMID: 28223533
    2. Results show that DIRAS1 is frequently methylated in human colorectal cancer and the expression of DIRAS1 is silenced by promoter region methylation. PMID: 28491151
    3. DiRas1 expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS and inhibiting the binding of other small GTPases to SmgGDS PMID: 26814130
    4. DIRAS1 downregulation is associated with esophageal squamous cell carcinoma metastasis. PMID: 23436800
    5. a novel Ras-related protein and potential neural tumor suppressor (RIG) PMID: 12107278

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  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族:
    Small GTPase superfamily, Di-Ras family
  • 組織特異性:
    Highly expressed in heart and brain.
  • 數據庫鏈接:

    HGNC: 19127

    OMIM: 607862

    KEGG: hsa:148252

    STRING: 9606.ENSP00000325836

    UniGene: Hs.172753



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