在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DIAPH3 Antibody

  • 中文名稱:
    DIAPH3兔多克隆抗體
  • 貨號:
    CSB-PA885723LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescent analysis of HepG2 cells using CSB-PA885723LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DIAPH3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AN antibody; AUNA1 antibody; Dia2 antibody; diap3 antibody; DIAP3_HUMAN antibody; DIAPH3 antibody; Diaphanous homolog 3 (Drosophila) antibody; Diaphanous homolog 3 antibody; Diaphanous related formin 3 antibody; Diaphanous; Drosophila; homolog of; 3 antibody; Diaphanous-related formin-3 antibody; DKFZp434C0931 antibody; DKFZp686A13178 antibody; DRF3 antibody; FLJ34705 antibody; mDia2 antibody; NSDAN antibody; OTTHUMP00000018480 antibody; Protein diaphanous homolog 3 antibody; RP11-26P21.1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein diaphanous homolog 3 protein (642-849AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,DIAPH3 Antibody (CSB-PA885723LA01HU),的標記方式是Non-conjugated。對于DIAPH3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA885723LB01HU DIAPH3 Antibody, HRP conjugated ELISA
    FITC CSB-PA885723LC01HU DIAPH3 Antibody, FITC conjugated
    Biotin CSB-PA885723LD01HU DIAPH3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.
  • 基因功能參考文獻:
    1. These data identify Diaph3 as a major guard of cortical progenitors, unravel novel functions of Diaphanous formins and add insights into the pathobiology of microcephaly. PMID: 27848932
    2. study demonstrated the oncogenic activity of DIAPH3 in the progression of hepatocellular carcinoma and suggested that PDIAPH3 might be a therapeutic target. PMID: 28795316
    3. Members of 3 generations of a family had dominant auditory neuropathy associated with a c.-172G>A point mutation in DIAPH3. PMID: 27658576
    4. DIAPH3 overexpression inhibits the migration and invasion of Triple-negative breast cancer by inhibiting RhoA-GTP expression. PMID: 28779705
    5. mDia2 and CXCR4 associate in blebs upon CXCL12 stimulation. Both CXCR4 and RhoA are required for CXCL12-induced blebbing PMID: 28115158
    6. we use a simple cellular system to examine fundamental features of formin-mediated filopodial assembly, using constitutively active constructs of the formins mDia2 and FMNL3 PMID: 26446836
    7. results suggest that inhibition of MT stability arising from DIAPH3 downregulation enhances susceptibility to MT poisons, and that the DIAPH3 network potentially reports taxane sensitivity in human tumors PMID: 26179371
    8. Dia1, Dia2, and Dia3 are involved in ErbB2-dependent capture of microtubules at the cell leading edge and ErbB2-driven guided migration. PMID: 24403606
    9. An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids. PMID: 24587343
    10. TGF-beta promotes association of mDia2 with actin stress fibers, which further drives stress fiber formation and myofibroblast differentiation PMID: 23580645
    11. In human tumours, DIAPH3 down-regulation was associated with aggressive or metastatic disease. PMID: 22593025
    12. isoform-selective actin assembly by DIAPH3 exerts specific and differentially regulated functions during cell adhesion and motility. PMID: 22184005
    13. the amino terminus of mDia2 serves as a coincidence detection module, directing mDia2 to the plasma membrane through interactions with phospholipids and activated Rif PMID: 21119010
    14. These findings reveal a key role for mDia3 and its regulation by Aurora B phosphorylation in achieving proper stable kinetochore microtubule attachment. PMID: 21397845
    15. These studies further suggest that Rho GTPases significantly influence the activity of mDia family formins in driving cellular membrane remodeling through the regulation of actin dynamics. PMID: 17198702
    16. DIP-induced membrane blebbing was dependent on Diaphanous 2 but did not require the activities of either Diaphanous 1 or Actin-Related Protein 2-3 Complex. PMID: 17398099
    17. Data show that Dia2 localizes in the lamella of migrating epithelial cells, where it is involved in the formation of a stable pool of cortical actin and in maintenance of polymerization-competent free filament barbed ends at focal adhesions. PMID: 17855386
    18. Results suggest that WAVE and the Arp2/3 complex jointly orchestrate different types of actin-based plasma membrane protrusions by promoting ruffling and inhibiting mDia2-induced filopodia. PMID: 18516090
    19. active Drf3 lacking the C-terminal regulatory region (Drf3DeltaDAD) induced the formation of filopodia and accumulated at their tips. PMID: 18755006
    20. mDia2 is degraded at the end of mitosis; mDia2 is targeted for disposal by post-translational ubiquitin modification; forced expression of activated mDia2 yields binucleate cells due to failed cytokinesis PMID: 19457867

    顯示更多

    收起更多

  • 相關疾病:
    Auditory neuropathy, autosomal dominant, 1 (AUNA1)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Formin homology family, Diaphanous subfamily
  • 數據庫鏈接:

    HGNC: 15480

    OMIM: 609129

    KEGG: hsa:81624

    STRING: 9606.ENSP00000383178

    UniGene: Hs.283127



主站蜘蛛池模板: 欧美成人国产精品高潮| 成人免费无码不卡毛片| 国产成人精品s8视频| 色婷婷香蕉在线一区二区| 又紧又大又爽精品一区二区| 精品国产美女av久久久久 | 18岁日韩内射颜射午夜久久成人| 久久久无码精品亚洲日韩啪啪网站| 欧美xxxx做受视频| 黑人大荫蒂老太大| 久久96国产精品久久久| 97人妻免费碰视频碰免| 久久精品手机观看| 巨胸不知火舞露双奶头无遮挡 | 国产性生大片免费观看性| 国产普通话对白刺激| 消息称老熟妇乱视频一区二区| 欧美成aⅴ人高清怡红院| 少妇无码av无码去区钱| 国产精品一久久香蕉国产线看观看 | 亚洲国产aⅴ成人精品无吗| 日韩精品一区二区三区影院| 精品国产中文字幕在线视频| 国产人成无码视频在线观看| 大伊香蕉精品视频在线天堂 | 少妇愉情理伦片丰满丰满午夜| 综合自拍亚洲综合图区欧美| 色偷偷女人的天堂亚洲网| 欧美日韩视频无码一区二区三| 日韩精品乱码av一区二区| 亚洲国产天堂久久久久久| 国产精品无码翘臀在线看| 国产欧美日韩综合精品一区二区| 狠狠躁夜夜躁人人爽蜜桃| 午夜内射中出视频| 欧美日产国产精品| 护士脱了内裤让我爽了一夜视频| 亚洲中文字幕无码中文| 国内精品一区二区三区| 人人做人人爽人人爱| 亚洲制服 视频在线观看|