在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DHX58 Antibody

DHX58 Antibody

  • 中文名稱：
    DHX58兔多克隆抗體
  • 貨號(hào)：
    CSB-PA822187ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: DHX58 antibody at 12μg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Rat kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 77 kDa
      Observed band size: 77 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA822187ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822187ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DHX58 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    D11LGP2 antibody; D11lgp2e antibody; DEXH (Asp Glu X His) box polypeptide 58 antibody; DEXH box polypeptide 58 antibody; DHX 58 antibody; DHX58 antibody; DHX58_HUMAN antibody; LGP 2 antibody; LGP2 antibody; Ortholog of mouse D11lgp2 antibody; Probable ATP dependent helicase LGP2 antibody; Probable ATP dependent RNA helicase DHX58 antibody; Probable ATP-dependent helicase LGP2 antibody; Probable ATP-dependent RNA helicase DHX58 antibody; Protein D11Lgp2 homolog antibody; RIG-I-like receptor LGP2 antibody; RLR antibody; RNA helicase LGP2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human Probable ATP-dependent RNA helicase DHX58 protein (389-678AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
  • 基因功能參考文獻(xiàn)：
    1. Study demonstrated a tumor suppressor role of LGP2 in neuroblastoma (NB). LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients. PMID: 30179292
    2. genetic loss of LGP2 uncovers dsRNA-mediated RNAi albeit less strongly than complete loss of the IFN system PMID: 29351913
    3. Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion. PMID: 28760986
    4. study documents that recombinant measles virus produce defective interfering genomes that have high immunostimulatory properties via their binding to RIG-I and LGP2 proteins, both of which are cytosolic nonself RNA sensors of innate immunity. PMID: 28768856
    5. essential role in activating interferon signaling against hepatitis C virus (HCV) infection by promoting MDA5 recognition of HCV pathogen-associated molecular patterns PMID: 28090671
    6. LGP2 did not reveal significant single-SNP associations with multiple sclerosis risk. PMID: 25288302
    7. LGP2 increases the initial rate of MDA5-RNA interaction and regulates MDA5 filament assembly. PMID: 25127512
    8. results demonstrate previously unrecognized properties of LGP2 ATP hydrolysis and RNA interaction and provide a mechanistic basis for a positive regulatory role for LGP2 in antiviral signaling PMID: 23184951
    9. LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response PMID: 22837208
    10. Paramyxovirus 5 V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon beta induction. PMID: 22301134
    11. LGP2 functions as an inhibitor of the innate immune response triggered by Rabeis virus infection PMID: 21525357
    12. LGP2 competes with the kinase IKKi for a common interaction site on IPS-1, as an element of negative-feedback regulation of intracellular antiviral signaling. PMID: 17020950
    13. LGP2 can be coexpressed with RIG-I to inhibit activation of the NF-kappaB reporter expression and that LGP2 protein produced in insect cells can bind both single- and double-stranded RNA (dsRNA), with higher affinity and cooperativity for dsRNA. PMID: 18411269
    14. The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. PMID: 19278996
    15. Cloning and expression of the mouse Lpg2 mRNA, and comparison of the ORF to that of human LPG2 mRNA. PMID: 11735219

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Helicase family, RLR subfamily
  • 組織特異性：
    Expressed in testis, nerve and spleen. Also expressed in the brain.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29517

    OMIM: 608588

    KEGG: hsa:79132

    STRING: 9606.ENSP00000251642

    UniGene: Hs.55918



主站蜘蛛池模板： 无码ol丝袜高跟秘书在线观看| 伊人久久大香线蕉av一区| 国内精品久久久久影院薰衣草| 久久青青草原国产精品最新片| 免费看国产zzzwww色| 99精品久久精品一区二区| 香港三级韩国三级日本三级 | 噜噜久久噜噜久久鬼88 | 苍井空亚洲精品aa片在线播放| 特黄做受又粗又长又大又硬| 邪恶肉肉全彩色无遮盖| 国产人妖乱国产精品人妖| 男人下部进女人下部视频| 日韩av无码社区一区二区三区| 国产午夜人做人免费视频网站| 欧美大荫蒂毛茸茸视频| 日本亲近相奷中文字幕| 亚洲欧美日韩在线资源观看| 午夜福利av无码一区二区| 女被男啪到哭的视频网站| 无码国模国产在线观看免费| 久久久久国色av∨免费看| 午夜免费男女aaaa片| 国产激情视频一区二区三区| 欧美日激情日韩精品嗯| 2023国产精品一卡2卡三卡4卡| 久久久久无码国产精品一区 | 韩国精品视频一区二区在线播放| 亚洲精品乱码久久久久久蜜桃图片| 国产精品国产三级欧美二区| 欧美日韩亚洲国产综合乱| 好男人社区在线www| 精品国产免费一区二区三区香蕉| 好紧好爽免费午夜视频| 两女女百合互慰av赤裸无遮挡| 精品乱码一区二区三四区视频| 夜色约爱网站| 国语精品自产拍在线观看网站 | 996久久国产精品线观看| 亚洲日本在线在线看片| 精品人妻va出轨中文字幕|