在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DHRS2 Antibody

DHRS2 Antibody

  • 中文名稱：
    DHRS2兔多克隆抗體
  • 貨號：
    CSB-PA002139
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using DHRS2 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DHRS2
  • 別名：
    DHRS2 antibody; SDR25C1 antibody; Dehydrogenase/reductase SDR family member 2 antibody; mitochondrial antibody; EC 1.1.1.- antibody; Dicarbonyl reductase HEP27 antibody; Protein D antibody; Short chain dehydrogenase/reductase family 25C member 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human DHRS2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
  • 基因功能參考文獻(xiàn)：
    1. DHRS2 and DHRS4 genes are syntenic outparalogues originating from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade PMID: 23036705
    2. A rapid divergent evolution brought the human DHRS2 gene, duplicated form of the DHRS4 one, to code a SDR enzyme having subcellular localization, synthesis regulation and specialized cellular functions very different from those of the human DHRS4 enzyme. PMID: 23036705
    3. Complete genomic organization of DHRS2, including two alternative promoter regions: a hepatocyte-specific promoter and a monocyte-derived dendritic cell-specific promoter PMID: 11944995
    4. c-Myb proto-oncogene has a tumor suppressor role in breast cancer via c-Myb controlled DHRS2 (HEP27) expression. PMID: 20949095
    5. Hep27 is regulated at the transcriptional level by the proto-oncogene c-Myb and is required for c-Myb-induced p53 stabilization. PMID: 20547751
    6. Molecular cloning, sequence and Chr 14 localization of the DHRS2 gene. Nuclear and cytoplasmic localization and normal tissue distribution of the DHRS2-encoded Hep27 protein. PMID: 11997086
    7. The synthesis of the nuclear protein D (Hep27 protein old name) is up-regulated in growth-inhibited HepG2 cells and is inhibited during DNA synthesis. PMID: 1847869
    8. In human endometrial carcinoma cells, the Hep27 protein encoded by DHRS2 is specifically upregulated in mitochondria by the ERM/ETV5 transcription factor and Hep27 has a protective role against apoptosis induced by oxidative stress. PMID: 19443906
    9. Hep27 a cell-cycle regulated protein belongs to the SDR family (short-chain dehydrogenase/reductase family). PMID: 7556196
    10. Hep27 is a NADPH-dependent dicarbonyl reductase enzyme active on xenobiotics. PMID: 16685466

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18349

    OMIM: 615194

    KEGG: hsa:10202

    STRING: 9606.ENSP00000344674

    UniGene: Hs.272499



主站蜘蛛池模板： 中国china露脸自拍性hd| 热99re久久精品国产首页免费| 国产精品自在线一区| 国产国拍精品av在线观看按摩| 人妻去按摩店被黑人按中出| 寂寞少妇做spa按摩无码| 中文字幕在线亚洲二区| 在线观看国产丝袜控网站| 国产裸拍裸体视频在线观看| 69久久精品无码一区二区| 国产成人精品免费视频大全五级| 在线观看国产精品va| 国产内射老熟女aaaa| 国产精品186在线观看在线播放| 色欲天天婬色婬香综合网完整| 忘忧草社区在线资源www| 揉着我的奶从后面进去视频| 人妻人人澡人人添人人爽| 蜜桃视频韩日免费播放| 国产成人一区二区青青草原| 无码国内精品人妻少妇蜜桃视频| 国产口爆吞精在线视频| 国产精成a品人v在线播放 | 毛片无遮挡高清免费| 欧美黑人又粗又大久久久| 久久精品国产99久久久古代| 天天爽天天摸天天碰| 午夜精品影视国产一区在线麻豆| 国产人与zoxxxx另类| 欧美激情一区二区三区| 伦理片无码电影在线看| 日韩av片无码一区二区不卡电影| 亚裔大战黑人老外av| 亚洲精品色情aⅴ色戒| 国产人妻精品一区二区三首| 国产精品成人av片免费看| 少妇被粗大的猛烈进出图片 | 无码国产69精品久久久久同性 | 国产97在线 | 日韩| 中文字幕在线精品视频入口一区| 国产老熟妇精品观看|