在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DHRS2 Antibody

DHRS2 Antibody

  • 中文名稱：
    DHRS2兔多克隆抗體
  • 貨號：
    CSB-PA002139
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using DHRS2 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DHRS2
  • 別名：
    DHRS2 antibody; SDR25C1 antibody; Dehydrogenase/reductase SDR family member 2 antibody; mitochondrial antibody; EC 1.1.1.- antibody; Dicarbonyl reductase HEP27 antibody; Protein D antibody; Short chain dehydrogenase/reductase family 25C member 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human DHRS2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
  • 基因功能參考文獻(xiàn)：
    1. DHRS2 and DHRS4 genes are syntenic outparalogues originating from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade PMID: 23036705
    2. A rapid divergent evolution brought the human DHRS2 gene, duplicated form of the DHRS4 one, to code a SDR enzyme having subcellular localization, synthesis regulation and specialized cellular functions very different from those of the human DHRS4 enzyme. PMID: 23036705
    3. Complete genomic organization of DHRS2, including two alternative promoter regions: a hepatocyte-specific promoter and a monocyte-derived dendritic cell-specific promoter PMID: 11944995
    4. c-Myb proto-oncogene has a tumor suppressor role in breast cancer via c-Myb controlled DHRS2 (HEP27) expression. PMID: 20949095
    5. Hep27 is regulated at the transcriptional level by the proto-oncogene c-Myb and is required for c-Myb-induced p53 stabilization. PMID: 20547751
    6. Molecular cloning, sequence and Chr 14 localization of the DHRS2 gene. Nuclear and cytoplasmic localization and normal tissue distribution of the DHRS2-encoded Hep27 protein. PMID: 11997086
    7. The synthesis of the nuclear protein D (Hep27 protein old name) is up-regulated in growth-inhibited HepG2 cells and is inhibited during DNA synthesis. PMID: 1847869
    8. In human endometrial carcinoma cells, the Hep27 protein encoded by DHRS2 is specifically upregulated in mitochondria by the ERM/ETV5 transcription factor and Hep27 has a protective role against apoptosis induced by oxidative stress. PMID: 19443906
    9. Hep27 a cell-cycle regulated protein belongs to the SDR family (short-chain dehydrogenase/reductase family). PMID: 7556196
    10. Hep27 is a NADPH-dependent dicarbonyl reductase enzyme active on xenobiotics. PMID: 16685466

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18349

    OMIM: 615194

    KEGG: hsa:10202

    STRING: 9606.ENSP00000344674

    UniGene: Hs.272499



主站蜘蛛池模板： 综合激情久久综合激情| 国产精品久久久久电影网| 国产成人av在线免播放观看| av在线播放日韩亚洲欧我不卡| 中文字幕亚洲码在线观看| 熟女人妻视频| 久久久久国产精品人妻| 国产又色又爽又黄好看的视频| 久久人妻国产精品| 任我爽橹在线精品视频| 亚洲中文字幕无码永久在线不卡| 天天躁日日躁很很很躁| 乱人伦中文视频在线| 麻豆国产人妻欲求不满| 蜜臀视频一区二区在线播放| 中国少妇内射xxxhd免费| 51精品国产人成在线观看| 国产免费丝袜调教视频| 国产av中文av无码av狼人| 13小箩利洗澡无码视频网站| 国产精品无码一区二区三区免费| 免费观看羞羞视频网站| 天堂俺去俺来也www色官网 | 丁香五月亚洲中文字幕| 国产精品免费久久久久软件| 久久精品中文字幕一区| 欧美熟妇另类久久久久久多毛| 乱码视频午夜间在线观看| 俺去啦俺来也五月天| 少妇裸体性生交| 国产精品久久国产精品99 gif| 欧美成 人版中文字幕| 精品人妻系列无码专区| 亚洲日本成本人观看| а天堂中文官网| 国内久久婷婷五月综合色| 欧美精品久久96人妻无码| 国产成a人亚洲精v品无码性色| 亚洲成av人在线播放无码| 欧美人妻体内射射| 国产精品99久久久久久董美香|