在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DHDDS Antibody

  • 中文名稱:
    DHDDS兔多克隆抗體
  • 貨號:
    CSB-PA006845GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DHDDS
  • 別名:
    DHDDS antibody; HDSDehydrodolichyl diphosphate synthase complex subunit DHDDS antibody; EC 2.5.1.87 antibody; Cis-isoprenyltransferase antibody; CIT antibody; Cis-IPTase antibody; Cis-prenyltransferase subunit hCIT antibody; Epididymis tissue protein Li 189m antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DHDDS
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
  • 基因功能參考文獻:
    1. Study describe a patient presenting with severe multisystem disease associated with DHDDS deficiency. As retinitis pigmentosa is the only clinical sign in previously reported cases, this report broadens the spectrum of phenotypes associated with this condition. PMID: 27343064
    2. findings show that eukaryotic cis-PT is composed of the NgBR and hCIT subunits. The strong conservation of the RXG motif among NgBR orthologs indicates that this subunit is critical for the synthesis of polyprenol diphosphates and cellular function. PMID: 28842490
    3. We identified the MAK and DHDDS mutations homozygously in only 2.1% and 0.8%, respectively, of patients of mixed ethnicity, but in 25.7% and 8.6%, respectively, of cases reporting Jewish ancestry PMID: 25255364
    4. A single-nucleotide mutation in the gene that encodes DHDDS has been identified by whole exome sequencing as the cause of the non-syndromic recessive retinitis pigmentosa (RP) in a family of Ashkenazi Jewish origin. PMID: 24664694
    5. A missense mutation in DHDDS is associated with autosomal-recessive retinitis pigmentosa. PMID: 21295282
    6. A variant in DHDDS is associated with retinitis pigmentosa. PMID: 21295283
    7. identification and amino acid sequence expressed in yeast PMID: 12591616
    8. identification and characterization; overexpression of CIT in CHO cells results in a modest increase in cis-isoprenyltransferase activity associated with microsomal fractions PMID: 14652022
    9. molecular cloning; results suggest a regulatory relationship between CPT activity and dolichol biosynthesis, and may implicate CPT in the levels of dolichol-oligosaccharide intermediate biosynthesis PMID: 15850770

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 59 (RP59)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Peripheral membrane protein. Note=colocalizes with calnexin.
  • 蛋白家族:
    UPP synthase family
  • 組織特異性:
    Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus.
  • 數據庫鏈接:

    HGNC: 20603

    OMIM: 608172

    KEGG: hsa:79947

    STRING: 9606.ENSP00000353104

    UniGene: Hs.369385



主站蜘蛛池模板: 中日产幕无线码一区| 亚洲国产精品高清久久久| 久久精品成人欧美大片| 2020年无码国产精品高清免费| 国产精品自在拍首页视频| 国产欧美性成人精品午夜| 国产麻豆9l精品三级站| 欧洲一卡2卡3卡4卡国产| 亚洲人成电影在线天堂色| 国产丰满老熟妇乱xxx1区| 狠狠综合久久久久尤物丿| 怡春院国产精品视频| 2021少妇久久久久久久久久| 国产精品久久久一区二区三区| 国产精品免费精品自在线观看| 日本理伦片午夜理伦片| 精品午夜国产福利观看| 伊人久久久大香线蕉综合直播| 国产精品爽爽久久久久久| 人妻无码中文字幕| 乱子伦av无码中文字| 在线精品国产一区二区三区| 精品国产乱码久久久久夜深人妻| 日韩精品人妻无码久久影院| 欲女熟妇国产一区二区| 国产精品盗摄!偷窥盗摄| 男人添女人下部高潮视频| 亚洲国产成人av网站| 800av凹凸视频在线观看| 国产9色在线 | 日韩| 国产色诱视频在线观看| 2021最新国产精品网站| 少妇被粗大的猛烈进出视频| 免费国产a国产片高清| 性色av无码专区一ⅴa亚洲| 国产精品高清网站| 曰韩免费无码av一区二区| 午夜视频在线在免费| 亚洲中文字幕无码日韩精品| 一区二区三区在线 | 网站| 国产av福利第一精品|