在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DGUOK Antibody

DGUOK Antibody

  • 中文名稱：
    DGUOK兔多克隆抗體
  • 貨號：
    CSB-PA006842GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DGUOK
  • 別名：
    DGUOK antibody; DGK antibody; Deoxyguanosine kinase antibody; mitochondrial antibody; dGK antibody; EC 2.7.1.113 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DGUOK
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.
  • 基因功能參考文獻：
    1. DGUOK deficiency and mutation is associated with mitochondrial DNA depletion syndromes. PMID: 28493820
    2. rare homozygous p.N46S mutation associated with idiopathic noncirrhotic portal hypertension PMID: 26874653
    3. The goals of this work are to characterize the DGUOK rat in terms of mitochondrial dysfunction and pathological outcome, and to evaluate EPR as a new and additional technique in an integrated characterization of mitochondrial disease . PMID: 26773591
    4. sequencing results showed that the patient was a compound heterozygote for c.679G>A and c.817delT in the DGUOK gene PMID: 27324545
    5. thymidine kinase 2 but not deoxyguanosine kinase is up-regulated during the stationary growth phase of cultured cells PMID: 24940680
    6. study expands the spectrum of disorders caused by mutations in DGUOK. PMID: 23043144
    7. Deoxyguanosine kinase gene mutations combined with impaired glucose homeostasis and iron overload features are associated with severe progressive liver failure. PMID: 21107780
    8. c.592-4_c.592-3delTT mutation causes exon skipping and is and responsible for the DGUOK deficiency PMID: 19900589
    9. Neurological symptoms appeared later and were mild, in agreement with the limited brain pathology. Molecular analysis of the dGK gene should be performed in infants with cirrhosis even in the absence of CNS involvement. PMID: 15150663
    10. Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity PMID: 12054684
    11. A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA. Homozygous nonsense mutation in exon 3 of DGUOK (313C-->T). PMID: 12210798
    12. This study identified 2 novel homozygous mutations, G352A and C269T, that lead to truncated proteins in the hepatocerebral form of mitochondrial DNA depletion syndrome. PMID: 15883261
    13. DGUOK activity may play a crucial role in the phenotype reversal PMID: 17073823
    14. DGUOK is required for mitochondrial DNA replication in resting cells and that small changes in expression of this enzyme may cause mitochondrial DNA depletion. PMID: 17490647
    15. 15 different mutations in the DGUOK gene from 9 kindreds, were identified. PMID: 18205204
    16. study reports the first founder DGUOK mutation (c.444-62C>A) in two North-African families with hepatocerebral syndrome and severe combined respiratory chain deficiency PMID: 19394258
    17. a viral infection can trigger fulminant liver failure in the context of a genetic predisposition associated with mutations in DGUOK PMID: 19502998

    顯示更多

    收起更多

  • 相關疾病：
    Mitochondrial DNA depletion syndrome 3 (MTDPS3); Portal hypertension, non-cirrhotic (NCPH); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 (PEOB4)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    DCK/DGK family
  • 組織特異性：
    Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2858

    OMIM: 251880

    KEGG: hsa:1716

    STRING: 9606.ENSP00000264093

    UniGene: Hs.469022



主站蜘蛛池模板： 亚洲三区在线观看无套内射| 亚洲 熟女 久久 国产| 一区二区三区内射美女毛片 | 宅女午夜福利免费视频| 成年女性特黄午夜视频免费看| 国产婷婷色一区二区三区在线| 色欲视频综合免费天天| 国产精品va在线观看h| 国产日韩欧美一区二区东京热| 99香蕉国产精品偷在线观看| 国产精品毛片av在线看| 国产v综合v亚洲欧| 波多野结衣潮喷视频无码42| 免费三级网站| 成人区精品一区二区婷婷| 少妇精品偷拍高潮少妇小说| 国产高清国产精品国产专区| 97久久精品亚洲中文字幕无码 | 欧美黑人性暴力猛交喷水| 少妇激情一区二区三区视频| 99久久久无码国产精品性| 99久久精品国产成人综合 | 少妇被又大又粗下爽a片| 成年入口无限观看免费完整大片| 亚洲一区二区三区高清av| 人人爽久久涩噜噜噜av| 国产无遮挡a片又黄又爽漫画| 欧美性猛交xxxx黑人猛交| 欧洲熟妇色xxxxx欧美老妇伦| 国产一区丝袜在线播放| 国产 日韩 中文字幕 制服| 国产女人好紧好爽| 欧美成人看片一区二区| 欧美精品a∨在线观看| 大胆欧美熟妇xx| 国产真实夫妇交换视频| 国产成人亚洲无吗淙合青草| 久久国产精品无码网站| 中文字幕人成乱码熟女app| 国模无码人体一区二区| 精品av一区二区久久久|