在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DGKZ Antibody

DGKZ Antibody

  • 中文名稱：
    DGKZ兔多克隆抗體
  • 貨號：
    CSB-PA618788LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescent analysis of Hela cells using CSB-PA618788LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DGKZ Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DAG kinase zeta antibody; DAGK5 antibody; DAGK5 PEN antibody; DAGK6 antibody; DGK ZETA antibody; DGK-zeta antibody; Dgkz antibody; DGKZ_HUMAN antibody; Diacylglycerol kinase zeta antibody; Diglyceride kinase zeta antibody; hDGKzeta antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Diacylglycerol kinase zeta protein (11-152AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DGKZ Antibody (CSB-PA618788LA01HU)，的標記方式是Non-conjugated。對于DGKZ Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA618788LB01HU DGKZ Antibody, HRP conjugated ELISA
    FITC CSB-PA618788LC01HU DGKZ Antibody, FITC conjugated
    Biotin CSB-PA618788LD01HU DGKZ Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol. By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane.; Regulates RASGRP1 activity.; Does not regulate RASGRP1 activity.
  • 基因功能參考文獻：
    1. Results show that DGKzeta is downregulated in bone marrow mononuclear cells and associated with the severity of aplastic anemia (AA). Also, DGKzeta is a downstream target gene of miR34a. Their dysregulation enhances T-cell activation in AA cells. PMID: 28008152
    2. These results established the positive correlation between DGKzeta expression and gliomagrade. PMID: 26452358
    3. these data suggest that the activation of DGKzeta downstream of antigen recognition provides a mechanism that ensures the activation of PA-dependent signaling as a direct result of the strength of TCR-dependent DAG mobilization. PMID: 27999176
    4. Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) PMID: 27697466
    5. DGKzeta knockdown engenders enhancement of NF-kappaB pathway in response to TNF-alpha. [review] PMID: 26521214
    6. Redundant and specialized roles for diacylglycerol kinases alpha and zeta in the control of T cell functions. PMID: 25921290
    7. This study shows that DGKzeta knockdown facilitates degradation of IkappaB, followed by nuclear translocation of NF-kappaB p65 subunit. PMID: 25450975
    8. Elevated DGKzeta expression contributes to increased Rho GTPase activation and the enhanced motility of metastatic cancer cells. PMID: 24646293
    9. Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD) and DGKzeta enzymes are responsible for producing phosphatidic acid (PA). PMID: 23723068
    10. DGK-zeta translocated rapidly to the plasma membrane at early stages of immunological synapse (IS) formation independent of enzyme activity; study highlights a DGKzeta-specific function for local diacylglycerol metabolism at the IS and offers new clues to its mode of regulation PMID: 21937721
    11. Antigen-specific CD8-positive T cells from DGKzeta-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8+ T cells exhibit impaired expansion. PMID: 22271650
    12. Nucleosome assembly protein (NAP) 1-like 1 (NAP1L1) and NAP1-like 4 (NAP1L4) are identified as novel DGKzeta binding partners. PMID: 21996351
    13. Data show that Diacylglycerol that 2-arachidonoyl glycerol is a very poor substrate for either the epsilon or the zeta isoforms of diacylglycerol kinases. PMID: 21194521
    14. structural domain requirements for translocation and activity PMID: 12015310
    15. PKC alpha phosphorylates diacylglycerol kinase zeta in cells, and this phosphorylation inhibits its kinase activity to remove cellular diacylglycerol, thereby affecting cell growth. PMID: 12890670
    16. role in controlling the induction of luteinizing hormone beta transcription by ERK1/2 PMID: 14707140
    17. DGKzeta generating PA, stimulates PIP5KIalpha activity to increase local PIP2, which regulates actin polymerization. PMID: 15157668
    18. DGKzeta-derived phosphatidic acid acts as a mediator of mTOR signaling PMID: 15632115
    19. DGKzeta may act in vivo as a downstream effector of pRB to regulate nuclear levels of diacylglycerol and phosphatidic acid PMID: 16286473
    20. 2,3-dioleoylglycerol binds to a site on the alpha and zeta isoforms of diacylglycerol kinase that is exposed as a consequence of the substrate binding to the active site. PMID: 18004883
    21. PKD activation is induced by DGKzeta, suggesting DGK is an upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells. PMID: 18694729
    22. In DGKzeta-deficient fibroblasts PAK1 phosphorylation and Rac1-RhoGDI dissociation were attenuated, leading to reduced Rac1 activation after platelet-derived growth factor stimulation. PMID: 19211846
    23. None of SNPs of diacylglycerol kinase zeta tested showed association with bipolar disorder in Sardinian sample. PMID: 19308020
    24. Negative regulation of T cell receptor induced activation of the Ras-Erk1/2-AP1 pathway by DGKz PMID: 12070163

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 組織特異性：
    Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas.; [Isoform 2]: Predominantly expressed in muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2857

    OMIM: 601441

    KEGG: hsa:8525

    STRING: 9606.ENSP00000412178

    UniGene: Hs.502461



主站蜘蛛池模板： 最新国产精品好看的精品| 亚洲色偷偷色噜噜狠狠99网| 无码人妻精品一区二区三| 欧美日韓性视頻在線| 亚洲成av人片在线观看高清| 三个男吃我奶头一边一个视频| 无码人妻精品中文字幕| 在线天堂资源www在线中文| 影视av久久久噜噜噜噜噜三级| 少妇放荡的呻吟干柴烈火免费视频 | 玩50岁四川熟女大白屁股直播| 嫩草国产露脸精品国产软件| 亚洲18禁私人影院| 韩国精品福利一区二区三区| av在线亚洲欧洲日产一区二区 | 日韩精品一区国产偷窥在线| 国内精品伊人久久久久av影院 | 免费看女人与善牲交| 国产精品系列无码专区| 亚洲aⅴ无码成人网站国产app| 精品国产一区二区三区色欲| 亚洲乱码一卡二卡卡3卡4卡| 精品香蕉99久久久久网站| 日韩超碰人人爽人人做人人添| 国产嘿嘿嘿视频在线观看| 在线观看成人无码中文av天堂不卡| 亚洲精品高清无码视频| 亚洲国产精品一区二区久久| 99视频有精品视频高清| 免费国产线观看免费观看| 色鬼7777久久| 精品无码久久久久国产手机版| 欲色影视天天一区二区色香欲| 成人乱码一区二区三区av| 亚洲乱码精品久久久久..| 欧美制服丝袜人妻另类| 亚洲欧美黑人深喉猛交群| 色婷婷av久久久久久久| 伊人精品一本久久综合| 亚洲一区二区三区中文字幕在线| 精品乱码一区内射人妻无码|