在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DGKZ Antibody

DGKZ Antibody

  • 中文名稱：
    DGKZ兔多克隆抗體
  • 貨號：
    CSB-PA618788LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescent analysis of Hela cells using CSB-PA618788LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DGKZ Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DAG kinase zeta antibody; DAGK5 antibody; DAGK5 PEN antibody; DAGK6 antibody; DGK ZETA antibody; DGK-zeta antibody; Dgkz antibody; DGKZ_HUMAN antibody; Diacylglycerol kinase zeta antibody; Diglyceride kinase zeta antibody; hDGKzeta antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Diacylglycerol kinase zeta protein (11-152AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DGKZ Antibody (CSB-PA618788LA01HU)，的標記方式是Non-conjugated。對于DGKZ Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA618788LB01HU DGKZ Antibody, HRP conjugated ELISA
    FITC CSB-PA618788LC01HU DGKZ Antibody, FITC conjugated
    Biotin CSB-PA618788LD01HU DGKZ Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol. By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane.; Regulates RASGRP1 activity.; Does not regulate RASGRP1 activity.
  • 基因功能參考文獻：
    1. Results show that DGKzeta is downregulated in bone marrow mononuclear cells and associated with the severity of aplastic anemia (AA). Also, DGKzeta is a downstream target gene of miR34a. Their dysregulation enhances T-cell activation in AA cells. PMID: 28008152
    2. These results established the positive correlation between DGKzeta expression and gliomagrade. PMID: 26452358
    3. these data suggest that the activation of DGKzeta downstream of antigen recognition provides a mechanism that ensures the activation of PA-dependent signaling as a direct result of the strength of TCR-dependent DAG mobilization. PMID: 27999176
    4. Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) PMID: 27697466
    5. DGKzeta knockdown engenders enhancement of NF-kappaB pathway in response to TNF-alpha. [review] PMID: 26521214
    6. Redundant and specialized roles for diacylglycerol kinases alpha and zeta in the control of T cell functions. PMID: 25921290
    7. This study shows that DGKzeta knockdown facilitates degradation of IkappaB, followed by nuclear translocation of NF-kappaB p65 subunit. PMID: 25450975
    8. Elevated DGKzeta expression contributes to increased Rho GTPase activation and the enhanced motility of metastatic cancer cells. PMID: 24646293
    9. Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD) and DGKzeta enzymes are responsible for producing phosphatidic acid (PA). PMID: 23723068
    10. DGK-zeta translocated rapidly to the plasma membrane at early stages of immunological synapse (IS) formation independent of enzyme activity; study highlights a DGKzeta-specific function for local diacylglycerol metabolism at the IS and offers new clues to its mode of regulation PMID: 21937721
    11. Antigen-specific CD8-positive T cells from DGKzeta-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8+ T cells exhibit impaired expansion. PMID: 22271650
    12. Nucleosome assembly protein (NAP) 1-like 1 (NAP1L1) and NAP1-like 4 (NAP1L4) are identified as novel DGKzeta binding partners. PMID: 21996351
    13. Data show that Diacylglycerol that 2-arachidonoyl glycerol is a very poor substrate for either the epsilon or the zeta isoforms of diacylglycerol kinases. PMID: 21194521
    14. structural domain requirements for translocation and activity PMID: 12015310
    15. PKC alpha phosphorylates diacylglycerol kinase zeta in cells, and this phosphorylation inhibits its kinase activity to remove cellular diacylglycerol, thereby affecting cell growth. PMID: 12890670
    16. role in controlling the induction of luteinizing hormone beta transcription by ERK1/2 PMID: 14707140
    17. DGKzeta generating PA, stimulates PIP5KIalpha activity to increase local PIP2, which regulates actin polymerization. PMID: 15157668
    18. DGKzeta-derived phosphatidic acid acts as a mediator of mTOR signaling PMID: 15632115
    19. DGKzeta may act in vivo as a downstream effector of pRB to regulate nuclear levels of diacylglycerol and phosphatidic acid PMID: 16286473
    20. 2,3-dioleoylglycerol binds to a site on the alpha and zeta isoforms of diacylglycerol kinase that is exposed as a consequence of the substrate binding to the active site. PMID: 18004883
    21. PKD activation is induced by DGKzeta, suggesting DGK is an upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells. PMID: 18694729
    22. In DGKzeta-deficient fibroblasts PAK1 phosphorylation and Rac1-RhoGDI dissociation were attenuated, leading to reduced Rac1 activation after platelet-derived growth factor stimulation. PMID: 19211846
    23. None of SNPs of diacylglycerol kinase zeta tested showed association with bipolar disorder in Sardinian sample. PMID: 19308020
    24. Negative regulation of T cell receptor induced activation of the Ras-Erk1/2-AP1 pathway by DGKz PMID: 12070163

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 組織特異性：
    Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas.; [Isoform 2]: Predominantly expressed in muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2857

    OMIM: 601441

    KEGG: hsa:8525

    STRING: 9606.ENSP00000412178

    UniGene: Hs.502461



主站蜘蛛池模板： 日日摸日日碰夜夜爽av| 日日摸日日碰夜夜爽亚洲综合 | 亚洲国产精品无码av| 已婚少妇美妙人妻系列| 精品黑人一区二区三区久久| 欧美 国产日韩 综合在线| 久久精品国产男包| 99国产精品久久久久久久久久久| 狠狠的干性视频| 99久久久国产精品无码免费| 又黄又爽又高潮免费毛片| 四虎精品国产永久在线观看| 日韩精品久久久久久免费 | 在线精品视频一区二区三区| 伊人www22综合色| 天堂а√中文最新版在线| 午夜性刺激在线视频免费| 中文字幕在线播放| а√中文在线资源库| 永久免费毛片在线播放| 欧美最新精品videossexohd| 久久国产成人午夜av影院| 欧美18精品久久久无码午夜福利| 亚洲国产成人无码av在线播放| 欧美三级午夜理伦三级| 国产香蕉视频在线播放| 人妻熟女av一区二区三区| 伊人久久大香线蕉无码不卡| 内射少妇一区27p| 深夜福利啪啪片| av在线 高清不卡区| 免费午夜男女高清视频 | 四虎影在永久在线观看| 免费观看日本污污ww网站| 国产又粗又硬又大爽黄老大爷视频| 日本大片免a费观看视频| 天天做天天欢摸夜夜摸狠狠摸| 2022一本久道久久综合狂躁| 桃花色综合影院| 国产精品一区二区av蜜芽| 男人的天堂2018无码|