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  4. DGKI Antibody

DGKI Antibody

  • 中文名稱：
    DGKI兔多克隆抗體
  • 貨號：
    CSB-PA002136
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using DGK-ι Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DGKIDiacylglycerol kinase iota antibody; DAG kinase iota antibody; EC 2.7.1.107 antibody; Diglyceride kinase iota antibody; DGK-iota antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human DGK-ι.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position. By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression.
  • 基因功能參考文獻：
    1. the DGKI methylation status identified 22% of poorly responding patients in the low-risk group PMID: 25233099
    2. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. PMID: 21203819
  • 亞細胞定位：
    Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 組織特異性：
    Specifically expressed in brain and retina. In brain, highly expressed in hippocampus, caudate nucleus, occipital pole, cerebral cortex, and cerebellum. Also detected in kidney.
  • 數據庫鏈接：

    HGNC: 2855

    OMIM: 604072

    KEGG: hsa:9162

    STRING: 9606.ENSP00000288490

    UniGene: Hs.242947



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