在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DGKE Antibody

  • 中文名稱:
    DGKE兔多克隆抗體
  • 貨號:
    CSB-PA006835ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Diacylglycerol kinase epsilon antibody at 5μg/ml
      Lane 1: Rat brain tissue
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 64, 21 kDa
      Observed band size: 64 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006835ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006835ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DGKE Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DGKE; DAGK5; Diacylglycerol kinase epsilon; DAG kinase epsilon; Diglyceride kinase epsilon; DGK-epsilon
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Diacylglycerol kinase epsilon protein (40-260AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently.
  • 基因功能參考文獻:
    1. mutations can lead to atypical hemolytic uremic syndrome or membranoproliferative glomerulonephritis PMID: 28526779
    2. Letter/Case Report: atypical haemolytic uraemic syndrome in a Japanese patient with DGKE genetic mutations. PMID: 26018111
    3. Report DGKE intronic mutations located beyond the exon-intron boundaries in familial hemolytic uremic syndrome. PMID: 25854283
    4. Data suggest that complement dysregulation influences the onset and disease severity in carriers of diacylglycerol kinase-epsilon mutations PMID: 25135762
    5. DGKE silencing in resting endothelial cells does not affect complement activation at their surface. PMID: 25498910
    6. Our study expands the clinical phenotypes associated with mutations in DGKE and challenges the benefits of complement blockade treatment in such patients PMID: 24511134
    7. DGKzeta localizes to the nucleus and is considered to regulate nuclear diacylglycerol signaling.[review] PMID: 24119575
    8. Fully activating high-density transfected muscarinic receptors (M1Rs) by oxotremorine-M (Oxo-M) leads to similar calcium, DAG, and PKC signals, but PIP2 is depleted. PMID: 23630338
    9. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. PMID: 23542698
    10. Substrate specificity of DGKE is not a consequence of competition with hydrolysis of ATP. PMID: 23261795
    11. performed homozygosity mapping and whole exome sequencing in a Turkish consanguineous family and identified DGKE gene variants as the cause of a membranoproliferative-like glomerular microangiopathy PMID: 23274426
    12. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. PMID: 22511757
    13. A role for diacylglycerol kinase (DGK) and its downstream product phosphatidic acid (PA) in ANCA-induced neutrophil exocytosis, is reported. PMID: 21833457
    14. The region responsible for this arachidonoyl specificity is the lipoxygenase (LOX)-like motif found in the accessory domain, adjacent to DGKvarepsilon's catalytic site. PMID: 22266092
    15. diacylglycerol kinase-epsilon (DGKepsilon) has less preference for the acyl chain at the sn-1 position of diacylglycerol (DAG) than the one at the sn-2 position PMID: 22108654
    16. DGK activity is reduced by oxidative stress in human mesangial cells cultured under high glucose conditions. PMID: 21725595
    17. The hydrophobic domain of diacylglycerol kinase epsilon does not contribute to substrate specificity but plays a role in permanently sequestering the enzyme to a membrane. PMID: 17455907
    18. The alpha and zeta isoforms of diacylglycerol kinase are inhibited by 2,3-dioleoylglycerol, but not the more substrate-selective epsilon isoform PMID: 18004883
    19. Substrate specificity of diacylglycerol kinase epsilon is determined by selectivity of the sn-1 and sn-2 acyl chains phosphatidic acid or diacylglycerol. PMID: 19744926

    顯示更多

    收起更多

  • 相關疾病:
    Nephrotic syndrome 7 (NPHS7); Hemolytic uremic syndrome atypical 7 (AHUS7)
  • 亞細胞定位:
    Membrane; Single-pass membrane protein. Cytoplasm.
  • 蛋白家族:
    Eukaryotic diacylglycerol kinase family
  • 組織特異性:
    Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).
  • 數據庫鏈接:

    HGNC: 2852

    OMIM: 601440

    KEGG: hsa:8526

    STRING: 9606.ENSP00000284061

    UniGene: Hs.239514



主站蜘蛛池模板: 国产日韩av在线播放| 无码精品久久久天天影视| 老子影院午夜伦手机不四虎卡| 波多野美乳人妻hd电影欧美| 看成年女人午夜毛片免费| 肉感饱满中年熟妇日本| 国产三级视频在线观看视| 国产乱人伦无无码视频试看| 久久婷婷五月综合色一区二区| 日本又色又爽又黄的视频免 | 8ⅹ8x擦拨擦拨成人免费视频 | 国产精品天干天干| 精品免费久久久久久久| 天堂在线资源中文在线8| 97热久久免费频精品99| 性欧美大战久久久久久久| 欧美性videos高清精品| 国内揄拍国内精品人妻浪潮av| 一級特黃色毛片免費看| 国产精品三级一区二区| 伊人久久大香线蕉亚洲| 变态另类先锋影音| 欧美日韩国产综合新一区| 可以直接看的无码av| 色欲色香天天天综合无码| 无遮挡18禁啪啪免费观看| 狠狠色噜噜狠狠狠狠7777米奇| 99久久综合狠狠综合久久| 国产 校园 另类 小说区| 国产美女精品视频线免费播放| 在线永久免费观看黄网站| 中文字幕人妻熟女人妻a片| 最新国产精品久久精品| 秋霞影院午夜伦a片欧美| 韩国精品一区二区三区无码视频| 亚洲乱码日产精品bd| 中国丰满少妇人妻xxx性董鑫洁 | 极品少妇被猛得白浆直流草莓视频| 亚洲精品国产电影| 天天爱天天做久久狠狠做| 草草浮力地址线路①屁屁影院|