在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DGKA Antibody

DGKA Antibody

  • 中文名稱：
    DGKA兔多克隆抗體
  • 貨號：
    CSB-PA002124
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of Lovo cells using DGK-α Polyclonal Antibody
    • Western Blot analysis of LOVO cells using DGK-α Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    80 kDa diacylglycerol kinase antibody; DAG kinase alpha antibody; DAGK antibody; DAGK1 antibody; DGK alpha antibody; DGK-alpha antibody; dgkA antibody; DGKA_HUMAN antibody; Diacylglycerol kinase alpha antibody; Diacylglycerol kinase; alpha 80kDa antibody; Diglyceride kinase alpha antibody; MGC12821 antibody; MGC42356 antibody; OTTHUMP00000242836 antibody; OTTHUMP00000242955 antibody; OTTHUMP00000244046 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human DGK-α.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol.
  • 基因功能參考文獻：
    1. Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) PMID: 27697466
    2. DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, and its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression. PMID: 27731506
    3. LIPFDGKA might serve as a potential possible biomarkers for diagnosis of gastric cancer, and their downregulation may bring new perspective into the investigation of gastric cancer prognosis PMID: 27498782
    4. An abandoned compound that also inhibits serotonin receptors may have more translational potential as a DGKa inhibitor, but more potent and specific DGKa inhibitors are sorely needed PMID: 26420856
    5. Decreased DNA methylation at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis. PMID: 26964756
    6. Redundant and specialized roles for diacylglycerol kinases alpha and zeta in the control of T cell functions. PMID: 25921290
    7. These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells. PMID: 24887021
    8. DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1 PMID: 25248744
    9. High diacylglycerol kinase alpha expression is associated with glioblastoma. PMID: 24158111
    10. DGKalpha is involved in hepatocellular carcinoma progression by activation of the MAPK pathway. PMID: 22425622
    11. DGK-alpha was more highly expressed in CD8-tumor-infiltrating T cellscompared with that in CD8non-tumor kidney-infiltrating lymphocytes. PMID: 22573804
    12. Antigen-specific CD8-positive T cells from DGKalpha-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8+ T cells exhibit impaired expansion. PMID: 22271650
    13. SAP-mediated inhibition of DGKalpha sustains diacylglycerol signaling, thereby regulating T cell activation PMID: 22048771
    14. Diacylglycerol kinase alpha is a key regulator of the polarised secretion of exosomes. PMID: 21252909
    15. findings further suggest that DGL-alpha and -beta may regulate neurite outgrowth by engaging temporally and spatially distinct molecular pathways PMID: 21493725
    16. Defects in both polymorphonuclear neutrophil (PMN) transendothelial migration and PMN diacylglycerol kinase alpha signaling are implicated as disordered functions in subjects with localized aggressive periodontitis. PMID: 14734770
    17. PPARgamma agonists upregulate DGKalpha production.This suppresses the diacylglycerol/protein-kinase-C signaling pathway. PMID: 15117825
    18. DGKalpha is crucial for the control of cell activation and also for the regulation of the secretion of lethal exosomes, which in turn controls cell death. PMID: 15870081
    19. ALK-mediated alphaDGK activation is dependent on p60src tyrosine kinase, with which alphaDGK forms a complex; alphaDGK activation is involved in the control of ALK-mediated mitogenic properties. PMID: 15928040
    20. These results strongly suggest that DGKalpha is a novel positive regulator of NF-kappaB, which suppresses TNF-alpha-induced melanoma cell apoptosis. PMID: 17276726
    21. diacylglycerol kinase alpha-conserved domains have a role in membrane targeting in intact T cells PMID: 17911109
    22. 2,3-dioleoylglycerol binds to a site on the alpha and zeta isoforms of diacylglycerol kinase that is exposed as a consequence of the substrate binding to the active site. PMID: 18004883
    23. Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells.( PMID: 18424699
    24. These results strongly suggest that DGKalpha positively regulates TNF-alpha-dependent NF-kappaB activation via the PKCzeta-mediated Ser311 phosphorylation of p65/RelA. PMID: 19751727

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 組織特異性：
    Expressed in lymphocytes.
  • 數據庫鏈接：

    HGNC: 2849

    OMIM: 125855

    KEGG: hsa:1606

    STRING: 9606.ENSP00000328405

    UniGene: Hs.524488



主站蜘蛛池模板： 熟女熟妇伦av网站| 四虎成人精品在永久免费| 亚洲人成亚洲人成在线观看| 欧美黑人添添高潮a片www| 人禽杂交18禁网站免费| 久久www色情成人免费| 国产无遮挡乱子伦免费精品| 欧美亚洲熟妇一区二区三区 | 伊人久久大香线蕉aⅴ色| 在线不卡av片免费观看| 国产在线拍揄自揄拍无码视频| 日本成熟少妇喷浆视频| 日本japanese漂亮丰满| 自慰无码一区二区三区| 亚洲人精品午夜射精日韩| 色8久久人人97超碰香蕉987| 亚洲成a人片在线播放| 亚洲欧美成人一区二区在线| 亚洲6080yy久久无码产自国产 | 色老头在线一区二区三区| 男女猛烈xx00免费视频试看| 最爽无遮挡行房视频| 国产成人a区在线观看| 麻豆专媒体一区二区| 亚洲综合中文字幕无线码| 亚洲精品99久久久久中文字幕| 天天天欲色欲色www免费| 欧美成人免费全部观看国产| 亚洲精品久久国产精品浴池 | 人人莫人人擦人人看| 日韩精品射精管理在线观看| 唐人社导航福利精品| 亚洲国产精品久久久久久| 久久综合给合久久国产免费| 俄罗斯少妇性xxxx另类| 欧洲熟妇色xxxx欧美老妇软件| 色婷婷av99xx| 人人做人人妻人人精| 四虎影在永久在线观看| 免费国产高清在线精品一区| 国产精品久久久久久亚洲毛片|