在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DFFA Antibody

  • 中文名稱:
    DFFA兔多克隆抗體
  • 貨號(hào):
    CSB-PA783338
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA783338(DFFA Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA783338(DFFA Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    A330085O09Rik antibody; Caspase activated deoxyribonuclease inhibitor short form antibody; DFF 1 antibody; DFF 45 antibody; DFF alpha antibody; DFF-45 antibody; DFF1 antibody; DFF35 antibody; DFF45 antibody; DFFA antibody; Dffa DNA fragmentation factor, alpha subunit antibody; DFFA_HUMAN antibody; DNA fragmentation factor 45 kDa subunit antibody; DNA Fragmentation Factor Alpha Subunit antibody; DNA fragmentation factor subunit alpha antibody; DNA fragmentation factor, 45 kD, alpha subunit antibody; DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1 antibody; DNA fragmentation factor, 45kDa, alpha polypeptide antibody; DNA fragmentation factor, alpha subunit antibody; DNAation factor 45 kDa subunit antibody; H13 antibody; ICAD antibody; ICAD L antibody; ICAD S antibody; Inhibitor of CAD antibody; Inhibitor of Caspase Activated DNase antibody; MGC143066 antibody; OTTHUMP00000001903 antibody; OTTHUMP00000001904 antibody; RP23 121D17.3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Fusion protein of Human DFFA
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Inhibitor of the caspase-activated DNase (DFF40).
  • 基因功能參考文獻(xiàn):
    1. Glandular, menopause-independent DFF40, DFF45, and Bcl-2 overexpression may play an important role in the pathogenesis of endometrial polyps and benign endometrial hyperplasia PMID: 28914671
    2. evaluate the relative expression levels of miR-196a2 and three of its selected apoptosis-related targets; ANXA1, DFFA and PDCD4 in a sample of GI cancer patients PMID: 29091952
    3. Data show that the caspase-activated DNase (CAD) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis. PMID: 26106156
    4. Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer. PMID: 24277473
    5. ICAD deficiency was associated with severe genomic instability. PMID: 23451280
    6. mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim, Bcl-x, and ICAD in Pnn-depleted MCF-7 cells. PMID: 22454513
    7. The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause. PMID: 22378161
    8. study reveals a previously unrecognized function of miR-145 in DFF45 processing, which may underlie crucial aspects of cancer biology PMID: 20687965
    9. The heterodimer, DFF40-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions. PMID: 19882353
    10. DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma tumors PMID: 11870543
    11. NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity PMID: 12144788
    12. Hypoxia-induced cleavage of caspase-3 and DFF45/ICAD in human failed cardiomyocytes. PMID: 12181128
    13. subunit structures and stoichiometries in human cells before and after induction of apoptosis PMID: 12748178
    14. Hepatitis C virus core protein increases a steady-state level of ICAD protein, possibly through enhancing its promoter activity PMID: 14675622
    15. apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression PMID: 16432220
    16. plays an important and P53-independent role in maintaining chromosome stability and suppressing tumor development PMID: 16619042
    17. demonstrate the cellular mechanisms of neuronal cell degeneration induced via c-Jun-N-terminal kinases and caspase-dependent signaling PMID: 17645689
    18. C-terminal region of each subunit, DFF40 (RLKRK) and DFF45 (KRAR), is essential for nuclear accumulation of the DFF complex. PMID: 17938174
    19. Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation. PMID: 17945178
    20. The highest level of DFF45 endometrial expression was found during the early secretory cycle phase, and significantly lower DFF45 expression was found in the endometrium during the mid-secretory as compared to the early secretory cycle phase. PMID: 18292826
    21. identified a TATA-less region upstream of the transcription start site as a basal promoter of the ICAD gene. An E-Box motif, which binds transcription factors of the basic helix-loop-helix/leucine zipper family, is responsible for transcriptional activity PMID: 18500556
    22. MPP(+) did not change the total levels of c-Jun but enhanced phosphorylation of c-Jun at Ser73 and cleavage of DNA fragmentation factor 45, which were diminished by selegiline. PMID: 18805449
    23. A decreased level of DFF45 observed in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression. PMID: 19535198

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 2772

    OMIM: 601882

    KEGG: hsa:1676

    STRING: 9606.ENSP00000366237

    UniGene: Hs.484782



主站蜘蛛池模板: 日韩人妻无码一区二区三区99| 乱码国产丰满人妻www| 东北女人啪啪对白| 亚洲熟妇久久精品| 久久精品亚洲男人的天堂| 乱子伦农村xxxxbbb| 琪琪午夜伦埋影院77| а√天堂www在线天堂小说| 亚洲中文字幕婷婷在线| 国产成久久免费精品av片| 久久精品无码av| 国产成年女人特黄特色毛片免| 国产乱人激情h在线观看| 2021国产精品午夜久久| 亚洲熟妇无码八v在线播放| 无码人妻精品丰满熟妇区| 国产v亚洲v天堂无码久久久| 一进一出抽搐gif| 亚洲va韩国va欧美va| 国产成人一区二区三区免费视频| av天堂中av世界中文在线播放| 自慰系列无码专区| 国产日韩综合一区二区性色av| 欧美老人巨大xxxx做受| a三级三级成人网站在线视频| 国产精品无需播放器在线观看 | 韩国的无码av看免费大片在线| 国产精品亚洲а∨天堂免下载| 四虎成人精品国产永久免费无码| 精品国偷自产在线| 激情内射亚州一区二区三区爱妻| 亚洲全部无码中文字幕| 亚洲午夜久久久无码精品网红a片| 欧美高潮喷水大叫| 欧美色欧美亚洲高清在线观看 | 狠狠做五月深爱婷婷伊人| 18禁止午夜福利体验区| 果冻传媒一区二区天美传媒| 伊人久久大香线蕉av网站| 18禁亚洲深夜福利人口| 国产麻豆精品久久一二三|