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  4. DENND5A Antibody

DENND5A Antibody

  • 中文名稱：
    DENND5A兔多克隆抗體
  • 貨號：
    CSB-PA757108LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA757108LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DENND5A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DENND5A
  • 別名：
    DENND5A antibody; KIAA1091 antibody; RAB6IP1DENN domain-containing protein 5A antibody; Rab6-interacting protein 1 antibody; Rab6IP1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DENN domain-containing protein 5A protein (1-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，DENND5A Antibody (CSB-PA757108LA01HU)，的標記方式是Non-conjugated。對于DENND5A Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA757108LB01HU DENND5A Antibody, HRP conjugated ELISA
    FITC CSB-PA757108LC01HU DENND5A Antibody, FITC conjugated
    Biotin CSB-PA757108LD01HU DENND5A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth.
  • 基因功能參考文獻：
    1. identification of an epileptic encephalopathy additionally featuring cerebral calcifications and coarse facial features caused by recessive loss-of-function mutations in DENND5A PMID: 27866705
    2. A RUN Domain from DENND5/Rab6IP1 binds sorting Nexin 1 and is involved in the trafficking of vesicles at the level of Golgi. PMID: 22558185
    3. crystal structure of Rab6a(GTP) in complex with a 378-residue internal fragment of the effector Rab6IP1 was solved at 3.2 angstroms resolution. This Rab6IP1 region encompasses an all alpha-helical RUN domain followed in tandem by a PLAT domain PMID: 19141279
  • 相關疾病：
    Epileptic encephalopathy, early infantile, 49 (EIEE49)
  • 亞細胞定位：
    Golgi apparatus membrane.
  • 蛋白家族：
    RAB6IP1 family
  • 數據庫鏈接：

    HGNC: 19344

    OMIM: 617278

    KEGG: hsa:23258

    STRING: 9606.ENSP00000328524

    UniGene: Hs.501857



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