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DEFA6 Antibody

  • 中文名稱:
    DEFA6兔多克隆抗體
  • 貨號:
    CSB-PA980801GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    DEFA6
  • 別名:
    alpha 6 antibody; DEF6 antibody; DEF6_HUMAN antibody; DEFA 6 antibody; DEFA6 antibody; Defensin 6 antibody; Defensin alpha 6 antibody; Defensin alpha 6 Paneth cell specific antibody; Defensin antibody; Defensin-6 antibody; HD 6 antibody; HD6 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Fusion protein of Human DEFA6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

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靶點(diǎn)詳情

  • 功能:
    Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
  • 基因功能參考文獻(xiàn):
    1. HD6 assembled into nanonets can prevent key steps in C. albicans pathogenesis PMID: 28198610
    2. alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans PMID: 28026958
    3. Downregulation of HD6 in noninflamed mucosa may contribute to mucosal barrier dysfunction of patients with Crohn's Disease. PMID: 26891258
    4. Paneth cell alpha-defensin 6 is an antimicrobial peptide. PMID: 25354318
    5. Native HD-6 readily self-assembles into elongated fibrils observable by transmission electron microscopy, agglutinates both Gram-negative and -positive bacteria, and prevents the Listeria monocytogenes from invading cultured cells. PMID: 25158166
    6. In the meta-analysis, DEFA6 rs13275170 and DEFB1 rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer. PMID: 23028900
    7. study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria PMID: 22722251
    8. Regions 2, 3 & 9, 10 were more hydrophobic than other regions. It was difficult for the HD molecule to have many conformations because of its 3 S-S bridges; however, it responds to various external factors by restricting conformation. PMID: 21873175
    9. Defensin alpha 6 (DEFA 6) may have a role in adenoma but not in progression to colon carcinoma PMID: 20979654
    10. defensin alpha6 is highly expressed in colon cancer cell lines PMID: 15613481
    11. Crystal structure of HD6. PMID: 17088326
    12. Human enteric defensin (HD)-5 and HD-6 were detected in Paneth cells, which are observed in the gastric metaplastic mucosa as well as small intestinal epithelia. PMID: 19250512

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  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Alpha-defensin family
  • 組織特異性:
    Paneth cells of the small intestine.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2765

    OMIM: 600471

    KEGG: hsa:1671

    STRING: 9606.ENSP00000297436

    UniGene: Hs.711



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