在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DDT Antibody

  • 中文名稱:
    DDT兔多克隆抗體
  • 貨號:
    CSB-PA006598GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DDT
  • 別名:
    D dopachrome decarboxylase antibody; D dopachrome tautomerase antibody; D-dopachrome decarboxylase antibody; D-dopachrome tautomerase antibody; DDCT antibody; Ddt antibody; DOPD_HUMAN antibody; Phenylpyruvate tautomerase II antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DDT
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
  • 基因功能參考文獻:
    1. D-dopachrome tautomerase transcription may be regulated in a cell-dependent manner, and was enhanced by AMPK activation in SGBS adipocytes through inhibiting the mTOR signaling PMID: 28445821
    2. The knockdown of D-DT and MIF, individually and additively, inhibited the proliferation, migration, and invasion in HeLa and SiHa cells and restrained the growth of xenograft tumor. PMID: 28338494
    3. These results have implications for the manner in which D-DT and MIF compete with each other for binding to the CD74 receptor and for the relative potency of DRa1-MOG-35-55 and RTL1000 for competitive inhibition of D-DT and MIF binding and activation through CD74. PMID: 27573366
    4. Study demonstrated that DDT was over- expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines in a pattern correlated with MIF, and knockdown of DDT and MIF in PANC- 1 cells cooperatively inhibited cell proliferation, invasion and tumor formation. The tautomerase activities of both MIF and DDT are required for their negative regulatory role in p53 and their tumor-promoting functions. PMID: 27434219
    5. DDT was increased in burn patients. PMID: 27209369
    6. Gene expression level of DDT is significantly higher in AD patients when compared to normal controls. PMID: 26943237
    7. High MIF-2 levels are predictive of the development of organ dysfunction in myocardial ischemia reperfusion injury. PMID: 26234719
    8. Both p53 wildtype and mutant human lung adenocarcinoma tumors rely on MIF family members for maximal cell growth and survival. PMID: 24932684
    9. findings identify DDT as a functionally redundant but more potent cytokine to MIF in cancer and suggest that current attempts to inhibit MIF signaling may fail because of DDT compensation. PMID: 24356968
    10. D-dopachrome tautomerase secreted from adipocytes acts on preadipocytes to promote IL-6 expression and to inhibit adipogenesis by suppressing the induction of genes encoding adipogenic regulators PMID: 22951300
    11. DDT acts on adipocytes to regulate lipid metabolism through AMPK and/or PKA pathway(s) and improves glucose intolerance caused by obesity. PMID: 22428043
    12. These data indicate that D-DT is a MIF-like cytokine. PMID: 21817065
    13. D-DT-dependent beta-catenin stabilization is regulated by COX-2 expression, suggesting the existence of an amplification loop between COX-2- and beta-catenin-mediated transcription in these cells PMID: 21071513
    14. role of tautomerase active site of macrophage migration inhibitory factor as a potential target for discovery of novel anti-inflammatory agents PMID: 11997397
    15. DDT is for the first time demonstrated in the skin and can be related to inflammation, and its covariation with MIF strengthens this observation. PMID: 12823441
    16. D-dopachrome tautomerase (D-DT) and macrophage migration inhibitory factor, individually and additively, promote vascular endothelial growth factor and CXCL8 expression in human lung adenocarcinoma cell lines. PMID: 18684922

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    MIF family
  • 數據庫鏈接:

    HGNC: 2732

    OMIM: 602750

    KEGG: hsa:1652

    STRING: 9606.ENSP00000215773

    UniGene: Hs.656723



主站蜘蛛池模板: 亚洲一卡2卡3卡4卡 精品 | 久久99精品国产99久久6| 国产日产欧产精品网站| 国产成人拍精品视频午夜网站 | 欧美 亚洲 国产 日韩 综aⅴ | 97精品一区二区视频在线观看| 天天躁日日摸久久久精品| 黑人粗大猛烈进出高潮视频| 亚洲人成网站18禁止| 亚洲色欲色欲大片www无码| 又粗又大又硬又长又爽| 国产未发育呦交视频| 国产少妇高潮在线观看| av电影在线观看| 97久久精品人人澡人人爽| 亚洲天堂2017无码| 动漫成人无码精品一区二区三区| 一本一本久久a久久精品综合麻豆| 激情五月婷婷| 四虎影视久久久免费观看| 人人妻人人爽人人澡av| 国产亚洲精品a片久久久| 精品熟女日韩中文十区| 久久精品女人天堂av麻| 国产欧美日韩另类在线专区| 久久久国产精品麻豆a片| 五月丁香六月综合缴清无码| 九个美女露脸撒尿嘘嘘视频| 人妻中出无码一区二区三区| 精品国产福利拍拍拍| 东北少妇不带套对白| 国产成人亚洲精品无码电影| 国产精品毛片更新无码| 人妻少妇精品无码专区app| 久久精品中文闷骚内射| 青草青在线视频在线观看| 久久国产亚洲高清观看| 好男人www社区| 日韩卡1卡2 卡三卡免费| 久久性色av亚洲电影| 337p粉嫩大胆噜噜噜|