在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DCUN1D1 Antibody

  • 中文名稱:
    DCUN1D1兔多克隆抗體
  • 貨號:
    CSB-PA006571GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DCUN1D1
  • 別名:
    DCUN1D1 antibody; DCN1 antibody; DCUN1L1 antibody; RP42 antibody; SCCRODCN1-like protein 1 antibody; DCUN1 domain-containing protein 1 antibody; Defective in cullin neddylation protein 1-like protein 1 antibody; Squamous cell carcinoma-related oncogene antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DCUN1D1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
  • 基因功能參考文獻:
    1. The expression of DCUN1D1 was significantly increased in colorectal cancer with a negative correlation to miR-520b expression in colorectal cancer tissues. PMID: 28470146
    2. DCUN1D1 is a target gene of miR-195 in cervical cancer cells. PMID: 29750306
    3. the DCN1-UBC12 interaction is inhibited by DI-591, a high-affinity, cell-permeable small-molecule inhibitor that binds to purified recombinant human DCN1 and DCN2 proteins with K i values of 10-12 nM PMID: 29074978
    4. SCRO has potential to become a new target for the treatment of PC PMID: 29077169
    5. We also found that both miR-195 and DCUN1D1 siRNAs can inhibit cell invasion possibly through downregulating Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9) at the post-transcriptional level, which can be attenuated by restoring the expression of DCUN1D1 PMID: 28791411
    6. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity. PMID: 25411243
    7. SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO PMID: 25349211
    8. Distinct preferences of UBC12 and UBE2F peptides for inhibiting different DCNLs, including the oncogenic DCNL1. PMID: 23201271
    9. substrate engagement prompts DCNL1 recruitment that facilitates the initiation of CUL2 neddylation and define DCNL1 as a "substrate sensor switch" for ECV activation. PMID: 23401859
    10. a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments. PMID: 21813641
    11. Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors. PMID: 15657565
    12. SCCRO regulates Gli1--a key regulator of the hedgehog (HH) pathway. PMID: 17018598
    13. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation PMID: 18826954
    14. SCCRO-induced invasion involves activation of MMP2 transcription in an AP2- and p53-dependent manner. PMID: 18980971
    15. The GG genotype of the DCUN1D1 rs4859147 Single Nucleotide Polymorphism represents a risk factor for the development of frontotemporal lobar degeneration , increasing the risk of about fourfold. PMID: 19473369

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 組織特異性:
    Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral ton
  • 數據庫鏈接:

    HGNC: 18184

    OMIM: 605905

    KEGG: hsa:54165

    STRING: 9606.ENSP00000292782

    UniGene: Hs.592789



主站蜘蛛池模板: 97se狠狠狠狠狼鲁亚洲综合色 | 性色av无码一区二区三区人妻| 国产 麻豆 日韩 欧美 久久| 午夜免费无码福利视频麻豆| 无码人妻少妇久久中文字幕蜜桃 | 极品新婚夜少妇真紧| 成 人免费va视频| 伊人情人色综合网站| 亚洲熟妇av一区二区三区宅男| 国产女人乱子对白av片| 强开小婷嫩苞又嫩又紧视频| 内射人妻视频国内| 2020年无码国产精品高清免费| 国产av天堂亚洲国产av天堂| 久人人爽人人爽人人片av| 国产精品怡红院在线观看| 无码中文字幕va精品影院| 精品久久久无码中文字幕天天| 国产免费无遮挡吸奶头视频| 国产亚洲精品久久久久小| 婷婷综合久久狠狠色99h| 天堂资源最新在线| 人妻 丝袜美腿 中文字幕| 精品国产丝袜自在线拍国语| 国产尤物在线视精品在亚洲| 亚洲精品一区三区三区在线观看| 寂寞骚妇被后入式爆草抓爆| 七月丁香五月婷婷首页| 99久久99久久精品免费观看| 亚洲熟熟妇xxxx| 欧美xxxx做受欧美69| 正在播放国产剧情亂倫| 一本色道无码不卡在线观看 | 春药玩弄少妇高潮吼叫| 国语精品自产拍在线观看网站 | 两女女百合互慰av赤裸无遮挡 | 日韩电影一区二区三区| 少妇做爰免费视看片| 蜜芽av无码精品国产午夜| 欧美三级在线播放| 国产后入清纯学生妹|