在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DCUN1D1 Antibody

  • 中文名稱:
    DCUN1D1兔多克隆抗體
  • 貨號:
    CSB-PA006571GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DCUN1D1
  • 別名:
    DCUN1D1 antibody; DCN1 antibody; DCUN1L1 antibody; RP42 antibody; SCCRODCN1-like protein 1 antibody; DCUN1 domain-containing protein 1 antibody; Defective in cullin neddylation protein 1-like protein 1 antibody; Squamous cell carcinoma-related oncogene antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DCUN1D1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
  • 基因功能參考文獻:
    1. The expression of DCUN1D1 was significantly increased in colorectal cancer with a negative correlation to miR-520b expression in colorectal cancer tissues. PMID: 28470146
    2. DCUN1D1 is a target gene of miR-195 in cervical cancer cells. PMID: 29750306
    3. the DCN1-UBC12 interaction is inhibited by DI-591, a high-affinity, cell-permeable small-molecule inhibitor that binds to purified recombinant human DCN1 and DCN2 proteins with K i values of 10-12 nM PMID: 29074978
    4. SCRO has potential to become a new target for the treatment of PC PMID: 29077169
    5. We also found that both miR-195 and DCUN1D1 siRNAs can inhibit cell invasion possibly through downregulating Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9) at the post-transcriptional level, which can be attenuated by restoring the expression of DCUN1D1 PMID: 28791411
    6. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity. PMID: 25411243
    7. SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO PMID: 25349211
    8. Distinct preferences of UBC12 and UBE2F peptides for inhibiting different DCNLs, including the oncogenic DCNL1. PMID: 23201271
    9. substrate engagement prompts DCNL1 recruitment that facilitates the initiation of CUL2 neddylation and define DCNL1 as a "substrate sensor switch" for ECV activation. PMID: 23401859
    10. a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments. PMID: 21813641
    11. Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors. PMID: 15657565
    12. SCCRO regulates Gli1--a key regulator of the hedgehog (HH) pathway. PMID: 17018598
    13. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation PMID: 18826954
    14. SCCRO-induced invasion involves activation of MMP2 transcription in an AP2- and p53-dependent manner. PMID: 18980971
    15. The GG genotype of the DCUN1D1 rs4859147 Single Nucleotide Polymorphism represents a risk factor for the development of frontotemporal lobar degeneration , increasing the risk of about fourfold. PMID: 19473369

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 組織特異性:
    Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral ton
  • 數據庫鏈接:

    HGNC: 18184

    OMIM: 605905

    KEGG: hsa:54165

    STRING: 9606.ENSP00000292782

    UniGene: Hs.592789



主站蜘蛛池模板: 国语自产少妇精品视频| 国产美女午夜福利视频| 精品无人乱码高清| 国产成人精品日本亚洲语音| 亚洲风情亚aⅴ在线发布| 久久成人影院精品777| 97国产精品人妻无码久久久| 韩国乱码片免费看| 亚洲一卡2卡3卡4卡5卡精品| 怡红院av一区二区三区| 天堂√最新版中文在线地址| 人妻少妇-嫩草影院| 无码被窝影院午夜看片爽爽jk| 狠狠噜天天噜日日噜视频麻豆| 亚洲国产精品无码久久98| 亚洲欧洲成人av每日更新 | 中文字幕精品亚洲无线码vr| 亚洲乱码一区av春药高潮| 久久丫精品久久丫| 日韩人妻无码制服丝袜视频| 超caopor在线公开视频| 婷婷伊人五月尤物| 国产亚洲精品久久久久久久久动漫| 一区二区三区波多野结衣在线观看| 美女粉嫩饱满的一线天mp4| 日日噜噜夜夜狠狠va视频| 成人免费无码大片a毛片抽搐色欲| 一区二区三区中文字幕| 一本到中文无码av在线精品| 久9热视频这里只精品18| 国产伦精品一区二区三区免费 | 私人毛片免费高清影视院| 国产日韩欧美久久久精品图片| 欧美牲交视频免费观看| 极品美女扒开粉嫩小泬| 成年女人a毛片免费视频| 人妻巨大乳挤奶水hd免费看| 免费播放婬乱男女婬视频国产| 欧美性色黄大片| 老子午夜精品无码| 伊人无码一区二区三区|