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DCP1A Antibody

  • 中文名稱：
    DCP1A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA244133
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA244133(DCP1A Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA244133(DCP1A Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DCP1A
  • 別名：
    DCP1 decapping enzyme homolog A antibody; Dcp1a antibody; DCP1A_HUMAN antibody; Decapping enzyme hDcp1a antibody; Decapping mRNA 1A antibody; HSA275986 antibody; mRNA decapping enzyme 1A antibody; mRNA-decapping enzyme 1A antibody; Nbla00360 antibody; Putative protein product of Nbla00360 antibody; Smad4 interacting transcriptional co activator antibody; Smad4-interacting transcriptional co-activator antibody; Smad4-interacting transcriptional co-activator antibody; SMAD4IP1 antibody; SMIF antibody; Transcription factor SMIF antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human DCP1A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development.
  • 基因功能參考文獻(xiàn)：
    1. Overexpression of DCP1A is associated with malignant melanoma. PMID: 29076924
    2. The results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway. PMID: 28488892
    3. The E3 ligase TRAF6 binds to DCP1a and indirectly regulates DCP1a phosphorylation, expression of decapping factors, and gene-specific mRNA decay. PMID: 27315556
    4. DCP1A rs11551405 may have a prognostic effect on survival of CM patients. PMID: 27578485
    5. The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6. PMID: 25970328
    6. Phosphorylation at serine 315, serine 319, and threonine 321 of DCP1A modulates IL-8 expression during respiratory syncytial virus infection. PMID: 25796077
    7. The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5'-to-3' mRNA degradation by XRN1 in human cells. PMID: 24510189
    8. Malin regulates the recruitment of mRNA-decapping enzyme 1A (Dcp1a) to processing bodies. PMID: 23131811
    9. hDcp1a has a role in control of processing body dynamics during the cell cycle via phosphorylation PMID: 23300942
    10. Reveal DCP1a as a multifunctional regulator of mRNA expression and suggest a role for JNK kinase phosphorylation in controlling the subcellular localization of DCP1a in response to stress or inflammatory stimuli. PMID: 21859862
    11. Data show the presence of P-body-like foci in mouse oocytes, as revealed by the presence of Dcp1a and the colocalization of RNA-associated protein 55 (RAP55) and the DEAD box RNA helicase Rck/p54. PMID: 19812249
    12. Overexpression of wild-type SMIF enhanced expression of TGFbeta/BMP regulated genes, whereas a dominant-negative SMIF mutant suppressed expression. PMID: 11836524
    13. These data suggest that a human decapping complex containing decapping enzymes hDcp1a and hDcp2 may be recruited to mRNAs containing premature termination codons by the hUpf proteins. PMID: 12417715

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  • 亞細(xì)胞定位：
    Cytoplasm, P-body. Nucleus.
  • 蛋白家族：
    DCP1 family
  • 組織特異性：
    Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18714

    OMIM: 607010

    KEGG: hsa:55802

    UniGene: Hs.476353



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