在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DCD Antibody, Biotin conjugated

  • 中文名稱:
    DCD兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA006537DD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DCD Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DCD
  • 別名:
    AIDD antibody; DCD 1 antibody; dcd antibody; DCD-1 antibody; DCD_HUMAN antibody; Dermcidin antibody; DSEP antibody; HCAP antibody; PIF antibody; Preproteolysin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dermcidin protein (20-110AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues.; Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.
  • 基因功能參考文獻:
    1. the present study suggests that dermcidin is a novel binding protein of lncRNA STCAT3, which serves an important role in the progress and clinical outcome of gastric cancer PMID: 30226544
    2. The results of this study suggest that these biomarker DCD can serve as a potential non-invasive early diagnosis platform reflecting PiB-PET imaging for Mild Cognitive Impairment and Alzheimer's Disease. PMID: 27392853
    3. this study shows that PIF regulates systemic immunity and targets protective regulatory and cytoskeleton proteins PMID: 26944449
    4. This is the first report of the presence of DCD in nasal mucosa and demonstration of DCD in clinical samples of human nasal secretions at clinically relevant concentrations, which may represent a novel arm of sinonasal airway innate defense. PMID: 27650261
    5. Identification of dermcidin in human sebaceous gland cells supports the concept that sebocytes play an important role in the innate immunity of the skin through the expression of antimicrobial peptides and specific lipids. PMID: 26718508
    6. Reduced DCD concentration in sweat in patients with inflammatory acne may permit proliferation of P. acnes in pilosebaceous units, resulting in progression of inflammatory acne. PMID: 25673161
    7. These findings imply that DCD promotes breast tumorigenesis via modulation of ERBB signaling pathways PMID: 25879571
    8. Dermcidin binds platelets and may inhibit the therapeutic action of aspirin following acute myocardial infarction. PMID: 25055737
    9. Data indicate that Y-P30/dermcidin expressed in placentas of first trimester pregnancies. PMID: 24969620
    10. Increased Dermcidin was also detected with immunoblotting. PMID: 24562771
    11. Crystal structure and functional mechanism of a human antimicrobial membrane channel PMID: 23426625
    12. major binding partners of LEKTI were found to be the antimicrobial peptide dermcidin and the serine protease cathepsin G and no kallikreins. PMID: 22588119
    13. Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat. PMID: 22262861
    14. revealed that Nck1 SH2 domain binds to the phosphotyrosine residue at position 20 (Y20) of the DCD PMID: 21397687
    15. dermcidin was a novel platelet aggregating agent, and potentiated the ADP induced thrombosis in the animal model as well as acutely inhibited glucose induced insulin synthesis. PMID: 20809104
    16. There was a significant correlation between weight loss and survival in the PIF-positive non-small-cell lung cancer patients. PMID: 20837461
    17. Data show that dermcidin adopts a flexible amphipathic alpha-helical structure with a helix-hinge-helix motif, which is a common molecular fold among antimicrobial peptides. PMID: 20510021
    18. identified as antibiotic peptide secreted by sweat glands PMID: 11694882
    19. Our results confirmed previous findings indicating that dermcidin-1L could have promising therapeutic potentials and shed new light on the structure-function relationship of dermcidin-1L. PMID: 15670776
    20. Reduced expression of dermcidin in sweat of patients with atopic dermatitis may contribute to the high susceptibility of these patients to skin infections and altered skin colonization with Staphylococcus aureus. PMID: 15944307
    21. NF-kappaB and STAT3 are activated by proteolysis inducing factor in human Kupffer cells and monocytes PMID: 16142329
    22. Functional analysis indicated that proteolytic processing of DCD-1L by Cathepsin D in human sweat modulates the innate immune defense of human skin. PMID: 16354654
    23. Dermcidin may function as an oncogene in hepatic as well as breast cells; Glycosylation is not required, but the importance of asparagine residues suggests a role for the proteolysis-inducing factor core peptide domain. PMID: 16685272
    24. This work suggests that DCD might participate in the regulation of placental function by means of modulating the proteolytic cascades on the trophoblastic cell surface. PMID: 17448443
    25. Dermcidin is a proliferation and survival factor in prostate cancer cells subjected to stressors found in the prostate cancer microenvironment. PMID: 17626247
    26. These data suggest that the disorder and order transition may be relevant for some biological functions of PIF/DCD. PMID: 18058718
    27. There is a growing body of evidence illustrating dermcidin as an oncogene and its Y-P30 subunite as a survival factor (Review) PMID: 18403914
    28. Expression of dermcidin in human primary tumours appears highly variable and is not induced substantially by hypoxia/oxidative stress in cell line model systems PMID: 18594538
    29. pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30. PMID: 18599487
    30. IRAK-4, which is essential for virtually all TLR signalling, was suppressed, whereas the precursor for the antibiotic peptide Dermcidin was up-regulated in HIV-infected cells. PMID: 19703016

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 組織特異性:
    Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.
  • 數據庫鏈接:

    HGNC: 14669

    OMIM: 606634

    KEGG: hsa:117159

    UniGene: Hs.350570



主站蜘蛛池模板: 亚洲欧洲中文日韩乱码av| 最新网站亚洲人成无码| 老司机午夜精品视频资源| 小13箩利洗澡无码视频网站| 337p大胆啪啪私拍人体| 亚洲欧洲无码一区二区三区 | 免费国产黄网站在线观看动图 | 五十路熟女一区二区三区 | 国产精品久久久久不卡绿巨人| 久久久av男人的天堂| 日日碰狠狠添天天爽五月婷| 亚洲熟妇av一区二区三区漫画| 成人精品视频一区二区三区| 亚洲伊人成综合人影院青青青| 成人欧美一区二区三区视频| ā片在线观看免费观看| 在线观看国产精品电影| 日日摸日日碰夜夜爽免费| 亚洲欧洲成人a∨在线| 无码国产色欲xxxx视频| 成年女人免费v片| 精品国产av一区二区果冻传媒| 中文字幕日韩一区二区不卡| 偷拍区清纯另类丝袜美腿| 亚洲人成无码网www电影榴莲| 欧美老妇疯狂xxxxbbbb| 在线成人www免费观看视频| 无码人妻丰满熟妇区五十路| 中文无码伦av中文字幕在线| 水蜜桃av导航| 久久国产劲爆∧v内射| 亚洲a成人无m网站在线| 国产手机精品一区二区| 韩国乱码伦视频免费| 在线涩涩免费观看国产精品| 真人一进一出120秒试看| 国产超碰人人模人人爽人人添| 久久精品丝袜高跟鞋| 男女无遮挡猛进猛出免费观看视频| 丰满少妇大力进入| 国产高清av首播原创麻豆|