在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DBI Antibody

  • 中文名稱:
    DBI兔多克隆抗體
  • 貨號:
    CSB-PA000798
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HuvEc cells using ACBP Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ACBD 1 antibody; ACBD1 antibody; ACBP antibody; ACBP_HUMAN antibody; Acyl CoA binding domain containing 1 antibody; Acyl CoA binding protein antibody; Acyl Coenzyme A binding domain containing 1 antibody; Acyl coenzyme A binding protein antibody; Acyl-CoA-binding protein antibody; CCK RP antibody; CCKRP antibody; Cholecystokinin releasing peptide trypsin sensitive antibody; DBI antibody; Diazepam-binding inhibitor antibody; Endozepine antibody; EP antibody; GABA receptor modulator antibody; MGC70414 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human ACBP.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
  • 基因功能參考文獻:
    1. ACBP increases the activity of ceramide synthase 2 (CerS2) by more than 2-fold and CerS3 activity by 7-fold. ACBP binds very-long-chain acyl-CoA esters, which is required for its ability to stimulate CerS activity. PMID: 28320857
    2. Serum endozepine-4 levels are increased in hepatic coma. PMID: 26290636
    3. Structural and functional properties of ACBD1, commonly known as ACBP. [Review] PMID: 25898985
    4. High ACBP expression is associated with non-small cell lung cancer. PMID: 24819876
    5. results indicate that a dysfunction of the neurosteroid system might be operative in BPD in spite of unchanged DBI plasma levels. PMID: 24401326
    6. There was a significant difference in the rs2276596 polymorphism C/A allele frequency of the DBI gene (P < 0.0001) between alcoholics and healthy controls. PMID: 24818357
    7. Acyl-CoA binding protein and epidermal barrier function. [review] PMID: 24080521
    8. Endogenous potentiation of GABAergic synaptic transmission and responses to GABA uncaging in the thalamic reticular nucleus is absent in mice in which DBI is deleted and mice in which benzodiazepine binding to alpha3 subunit-containing GABAARs is disrupted. PMID: 23727119
    9. A human preadipocyte cell line SGBS is well suited to examine differential expression of the Acyl-CoA binding protein (ACBP) during adipogenesis. PMID: 21448843
    10. The regulation of novel low-abundance transcript variants of human acyl-CoA binding protein, was analysed. PMID: 20345851
    11. Gene annotation enrichment analysis revealed ACBP-mediated down-regulation of 18 genes encoding key enzymes in glycerolipid, cholesterol and fatty acid metabolism. PMID: 20511713
    12. Data suggest that the presence of gamma-glutamyl hydrolase and diazepam-binding inhibitor in urine serves as a rationale for developing them as urinary markers of clinical outcomes for patients treated with neoadjuvant chemotherapy. PMID: 19815704
    13. PPRE in intron 1 of the ACBP gene is a bona fide PPARgamma-response element. PMID: 12015306
    14. ACBP has a role as an essential protein in human cells PMID: 12396232
    15. Missense changes in diazepam binding inhibitorwere not associated with schizophrenia PMID: 14755437
    16. Data show for the first time in a physiological context that transgenic expression of acyl-coenzyme A binding protein may play a role in liver fatty acyl-coenzyme A metabolism. PMID: 16042405
    17. Results identify new acyl-CoA binding protein transcripts in human and mouse tissues, generated by alternative first exon usage. PMID: 16055366
    18. Acyl coenzyme A-binding protein has a role in augmenting bid-induced mitochondrial damage and cell death by activating mu-calpain PMID: 16908521
    19. Here high resolution crystal structures of human cytosolic liver ACBP, unliganded and liganded with a physiological ligand, myristoyl-CoA are described. The binding of the acyl-CoA molecule induces only few structural differences near the binding pocket PMID: 17044054
    20. we obtained evidence from two Caucasian study populations that the minor allele of ACBP rs2084202 might be associated with reduced risk of type 2 diabetes PMID: 17262885
    21. study found a significant difference in the +529A/T (rs8192503) polymorphism allele frequency of the DBI gene between the alcoholics & controls; data suggest that mutation allele of the DBI gene polymorphism was one of the risk factors for alcoholism PMID: 18240651
    22. ACBP is a transcriptional regulator of the HMGCS1 and HMGCR genes encoding rate-limiting enzymes of cholesterol synthesis pathway. PMID: 19088433

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum. Golgi apparatus.
  • 蛋白家族:
    ACBP family
  • 組織特異性:
    Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.
  • 數據庫鏈接:

    HGNC: 2690

    OMIM: 125950

    KEGG: hsa:1622

    STRING: 9606.ENSP00000440698

    UniGene: Hs.78888



主站蜘蛛池模板: 一本无码中文字幕在线观| 日韩人妻无码一区二区三区99| 日本丰满妇人成熟免费中文字幕 | 爆乳喷奶水无码正在播放| 怡红院av一区二区三区| 国产av成人一区二区三区| 一本久道久久综合狠狠躁av| 国产精品久久久久久日本| 内射女校花一区二区三区| 欧美又大又硬又粗bbbbb| 国产喷水福利在线视频| 国产精品69人妻无码久久| 亚洲午夜福利精品无码不卡| 国产老熟女伦老熟妇露脸| 色综合久久88色综合天天| 国产日本精品视频在线观看| 吃奶呻吟打开双腿做受视频| 国产精品美女一区二区三区| 成人网站免费大全日韩国产| 亚洲成av人片天堂网老年人| 久久久免费无码成人影片| 天堂8在线新版官网| 亚洲色无码国产精品网站可下载| 日本一卡2卡3卡4卡5卡精品视频| 欧美日韩不卡合集视频| 亚洲欧美丝袜精品久久| 亚洲综合一区二区三区四区五区| 国产在线高清视频无码| 国产真人性做爰久久网站| 亚洲成熟女人毛毛耸耸多| 一本精品99久久精品77| 国产卡1卡2卡3麻豆精品免费| 國产一二三内射在线看片| 国产喷水1区2区3区咪咪爱av | 日本狂喷奶水在线播放212| 牲高潮99爽久久久久777| 天天爽夜夜爱| 西西人体大胆午夜啪啪| 久久久99精品成人片| 国产精品无码av一区二区三区| 国产精品久久久久久妇女|