DBF4B Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DBF4B Polyclonal antibody
Uniprot No.：

Q8NFT6
基因名：

DBF4B
別名：

Activator of S phase kinase like protein 1 antibody; Activator of S phase kinase-like protein 1 antibody; ASK like protein 1 antibody; ASK-like protein 1 antibody; ASKL1 antibody; chifb antibody; Chiffon homolog B antibody; DBF 4B antibody; DBF4 homolog B (S. cerevisiae) antibody; DBF4 homolog B antibody; Dbf4 related factor 1 antibody; Dbf4-related factor 1 antibody; dbf4b antibody; DBF4B_HUMAN antibody; DRF1 antibody; FLJ13087 antibody; MGC15009 antibody; Protein DBF4 homolog B antibody; ZDBF1B antibody; Zinc finger DBF type containing 1B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein DBF4 homolog B protein (1-300AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DBF4B Antibody (CSB-PA822784LA01HU)，的標記方式是Non-conjugated。對于DBF4B Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA822784LB01HU	DBF4B Antibody, HRP conjugated	ELISA
FITC	CSB-PA822784LC01HU	DBF4B Antibody, FITC conjugated
Biotin	CSB-PA822784LD01HU	DBF4B Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.
基因功能參考文獻：
1. Knockdown of the exon6-containing isoform (DBF4B-FL) significantly inhibits the tumorigenic potential of colon cancer. Overexpression of DBF4B-FL protects against DNA damage induced by SRSF1 knockdown. PMID: 29262322
2. Results describe a novel human protein, Drf1, related to both human and yeast Dbf4. Drf1 is a nuclear cell cycle-regulated protein which binds to Cdc7 and activates the kinase. PMID: 12065429
3. ASKL1 in a complex with Cdc7 may play a role in normal progression of both S and M phases PMID: 15668232
4. These results indicate that Ddk functions as an upstream regulator to monitor S-phase checkpoint signaling. PMID: 19111665
亞細胞定位：

Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.
組織特異性：

Widely expressed. Highly expressed in testis.
數據庫鏈接：

HGNC: 17883

OMIM: 611661

KEGG: hsa:80174

STRING: 9606.ENSP00000323663

UniGene: Hs.369998

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