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DAND5 Antibody

  • 中文名稱：
    DAND5兔多克隆抗體
  • 貨號：
    CSB-PA850835LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA850835LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA850835LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DAND5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DAND5
  • 別名：
    BMP antagonist 3 antibody; CER2 antibody; cerberus 2 antibody; Cerberus like 2 antibody; Cerberus-like protein 2 antibody; Cerl-2 antibody; CERL2 antibody; CKTSF1B3 antibody; COCO antibody; CRL2 antibody; Cysteine knot superfamily 1 antibody; Cysteine knot superfamily 1 BMP antagonist 3 antibody; DAN domain family member 5 antibody; Dand5 antibody; DAND5_HUMAN antibody; DANTE antibody; GREM3 antibody; Gremlin-3 antibody; MGC126849 antibody; SP1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DAN domain family member 5 protein (23-189AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，DAND5 Antibody (CSB-PA850835LA01HU)，的標記方式是Non-conjugated。對于DAND5 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA850835LB01HU DAND5 Antibody, HRP conjugated ELISA
    FITC CSB-PA850835LC01HU DAND5 Antibody, FITC conjugated
    Biotin CSB-PA850835LD01HU DAND5 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation.
  • 基因功能參考文獻：
    1. High DAND5 expression is associated with tumor growth and angiogenesis in breast cancer. PMID: 26908452
    2. In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy PMID: 28738792
    3. A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta ligands, induces dormant breast cancer cells to undergo reactivation in the lung. PMID: 22901808
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    DAN family
  • 數據庫鏈接：

    HGNC: 26780

    OMIM: 609068

    KEGG: hsa:199699

    STRING: 9606.ENSP00000323155

    UniGene: Hs.331981



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