在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DACH1 Antibody

  • 中文名稱:
    DACH1兔多克隆抗體
  • 貨號(hào):
    CSB-PA903639
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA903639(DACH1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA903639(DACH1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    DACH1
  • 別名:
    DACH antibody; Dach1 antibody; DACH1_HUMAN antibody; Dachshund family transcription factor 1 antibody; dachshund homolog 1 (Drosophila) antibody; Dachshund homolog 1 antibody; Dachsund homolog 1 antibody; FLJ10138 antibody; OTTHUMP00000018494 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human DACH1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
  • 基因功能參考文獻(xiàn):
    1. DACH1 expression is decreased in glomerulopathy imply a potential role for DACH1 in the this development of human chornic glomerulopathy. PMID: 27888806
    2. Knockdown of DACH1 expression can remarkably enhance the cell apoptosis, restrain the proliferation, migration and invasion of Capan-1 cells. PMID: 27609579
    3. DACH1 expression regulates the pancreatic cancer cell apoptosis. PMID: 27278537
    4. Low DACH1 expression is associated with invasion of lung adenocarcinoma. PMID: 26810067
    5. This study concludes that MiR-217 is the upstream regulator of PGC-1alpha in breast cancer regulation in vitro, possibly independent of DACH1 signaling pathway. PMID: 27916422
    6. Kaplan-Mier analysis of human NSCLC samples demonstrated that high DACH1 mRNA levels predicted favorable prognosis for relapse-free and overall survival. In agreement, high CXCL5 expression predicted a worse prognosis for survival. PMID: 25788272
    7. DACH1 expression was reduced in hepatocellular carcinoma even at early stage and associated with tumor progression. Overexpression inhibited HCC cell growth and migration by inactivating the Wnt pathway via GSK3beta phosphorylation to suppress beta-catenin. PMID: 25940701
    8. In breast cancer, some GATA3 effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2, DACH1, THSD4, representing major GATA3-controlled processes in cancer progression. PMID: 25410484
    9. Results indicated that DACH1 was a novel molecular marker of RCC and it attributed to the malignant behavior of renal cancer cells. PMID: 25322986
    10. Data indicate that dachshund family transcription factor 1 (DACH1) suppresses gastric cancer cell proliferation, invasion and metastasis by inhibiting transforming growth factor beta (TGF-beta) signalling pathways both in vitro and in vivo. PMID: 24912879
    11. results suggest that DACH1 loss of function results in increased cell growth, motility and invasiveness through TGF-beta-mediated EMT, and DACH1 loss of function has important therapeutic implications for targeted therapies of CRC PMID: 25778865
    12. DACH1 is a determinant of benign and malignant prostate epithelium cellular growth, migration, and cytokine abundance in vivo. PMID: 25769723
    13. Further evaluation of the methylation of DACH1, DKK1, and WIF1 in a clinical patient group confirmed the frequent methylation of WIF1 and intermediate or low frequency of methylation of DACH1 or DKK1, respectively. PMID: 25487617
    14. DACH1 inhibits aldosterone secretion in human adrenals, and transforming growth factor-beta signaling pathway is activated in DACH1 overexpressed cells and may mediate inhibition of aldosterone secretion in human adrenals. PMID: 25776071
    15. Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese PMID: 24465431
    16. Nuclear DACH1 expression appears to be a Luminal A biomarker predictive of good prognosis, but is not independent of clinical stage, tumour size, NPI status or systemic therapy. PMID: 24392136
    17. DACH1 is frequently methylated in human colorectal cancers (CRC) and methylation of DACH1 may serve as detective and prognostic marker in CRC. PMID: 24149323
    18. Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation. PMID: 24335958
    19. DACH1 binds p53 to inhibit NSCLC cellular growth. PMID: 23492369
    20. DACH1 gene promoter methylation could lead to a decrease or absence of DACH1 expression in endometrial carcinoma. PMID: 22781112
    21. the inability of C/EBPalpha and GATA-1 to down-regulate DACH1 expression induced by MLL-AF9 during myeloid differentiation may contribute to t(9;11) leukemogenesis. PMID: 22902925
    22. DACH1 is highly expressed in metastatic ovarian cancer compared with that of normal, benign, and borderline ovarian tissues and could play an important role in cancer growth. PMID: 22367319
    23. The knockdown of DACH1 blocked the cell cycle progression of HL-60 promyeloblastic cells through the decrease of cyclin D1, D3, F, and Cdk 1, 4, and 6 and increase in p21(Cip1), which in turn decreased the phosphorylation of the Rb protein. PMID: 22405764
    24. in cells growing in IGF-1 (and unresponsive to EGF), DACH1 is devoid of tumor suppressor activity. PMID: 21558809
    25. DACH1 is a distinctive tumor suppressor, which not only suppresses growth of tumor cells but also regulates bFGF-mediated tumor-initiating activity of glioma cells PMID: 21750150
    26. DACH1 represses gene transcription through direct DNA binding to the promoter region of target genes by recruiting the transcriptional co-regulator, TCERG1. PMID: 20956529
    27. Forkhead signaling is attenuated by the retinal determination factor DACH1 PMID: 20351289
    28. The altered expression of human DACH1 has been associated with tumor progression and metastasis. DACH1 inhibits breast cancer cellular proliferation via cyclin D1. PMID: 19502783
    29. Findings identify a role of EYA4 and possibly interacting SIX and DACH proteins in MPNSTs and suggest the EYA4 pathway as a rational therapeutic target. PMID: 19901965
    30. forms an alpha/beta structure containing a DNA binding motif similar PMID: 12057194
    31. DACH1 bound to endogenous NCoR and Smad4 in cultured cells; Smad4 was required for DACH1 repression of TGF-beta induction of Smad signaling PMID: 14525983
    32. identifed DACH enhancers in gene deserts PMID: 14563999
    33. The dachshund is required in mushroom body neurons for proper axon guidance and branching in Drosophila melanogaster. PMID: 15818552
    34. DACH1 repressed cyclin D1 through a novel mechanism via a c-Jun DNA-binding partner, requiring the DACH1 alpha-helical DS domain which recruits corepressors to the local chromatin. PMID: 16980615
    35. DACH1 plays an important role in negative regulation of RANKL gene expression in marrow stromal/preosteoblast cells in the bone microenvironment. PMID: 17891780
    36. These data identify a pathway by which an endogenous cell-fate determination factor blocks oncogene-dependent tumor metastasis via a key heterotypic mediator. PMID: 18467491
    37. DACH1 is hypermethylated in renal cell carcinoma. PMID: 18639284
    38. a statistical significance level for DACH1 in gastric cancer PMID: 18957060
    39. DACH1 inhibited ligand-dependent activity of AR mutations identified in patients with androgen-insensitive prostate cancer. The DS domain was sufficient for repression of the AR wild-type but failed to repress an AR acetylation site point mutant. PMID: 19351840
    40. Data show that DACH1 expression, which is lost in poor prognosis human breast cancer, functions as an endogenous inhibitor of ERalpha function. PMID: 19605405

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    DACH/dachshund family
  • 組織特異性:
    Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2663

    OMIM: 603803

    KEGG: hsa:1602

    UniGene: Hs.129452



主站蜘蛛池模板: 国产剧情无码播放在线看| 国内精品久久久久久久小说| 少妇粉嫩小泬喷水视频www| 精品乱码一区内射人妻无码| 欧美性生交xxxxx久久久| 国产成人久久综合77777| 久久tv中文字幕首页| 久久er99国产精品免费| 国产成人综合亚洲看片| 无码人妻精品一二三区免费| 欧美一区二区三区成人久久片| 乱子轮熟睡1区| 四虎成人永久在线精品免费| 国产∨亚洲v天堂无码久久久| 男女啪啪高潮无遮挡免费| 中文字幕人成无码人妻综合社区 | 鲁鲁网亚洲站内射污| 无码av免费一区二区三区| 日日摸日日添日日碰9学生露脸| 无遮挡午夜男女xx00动态| 少妇高潮惨叫久久久久电影| 妺妺窝人体色www在线观看| 亚洲色成人网一二三区| 欧洲美熟女乱又伦av影片| 无码少妇一区二区三区浪潮av| 亚洲精品久久久久午夜aⅴ| 国产裸拍裸体视频在线观看| 又黄又爽吃奶视频在线观看| 欧美牲交a欧美牲交vdo18| 最新在线精品国产福利| 天天av天天翘天天综合网色鬼| 欧美性生交大片18禁止| 国模无码人体一区二区| 久久无码中文字幕免费影院| 日日摸日日碰夜夜爽av| 狠狠色噜噜狠狠狠狠777米奇| 亚洲中文字幕av无码区 | 亚洲色成人www永久在线观看| 少妇三级全黄| 超碰国产天天做天天爽| 久久www色情成人免费观看|