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  4. Cd74 Antibody

Cd74 Antibody

Rare Species
  • 中文名稱：
    Cd74兔多克隆抗體
  • 貨號：
    CSB-PA004956LA01RA
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Cd74 antibody at 2µg/ml + Mouse lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 32, 25 kDa
      Observed band size: 32 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Rattus norvegicus (Rat) Cd74 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cd74 antibody; H-2 class II histocompatibility antigen gamma chain antibody; Ia antigen-associated invariant chain antibody; Ii antibody; MHC class II-associated invariant chain antibody; CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide antibody; CLIP)] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Rat, Mouse
  • 免疫原：
    Recombinant Rat H-2 class II histocompatibility antigen gamma chain protein (57-280AA)
  • 免疫原種屬：
    Rattus norvegicus (Rat)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，Cd74 Antibody (CSB-PA004956LA01RA)，的標記方式是Non-conjugated。對于Cd74 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA004956LB01RA Cd74 Antibody, HRP conjugated ELISA
    FITC CSB-PA004956LC01RA Cd74 Antibody, FITC conjugated
    Biotin CSB-PA004956LD01RA Cd74 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.; Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.; Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs).
  • 基因功能參考文獻：
    1. cytokine MIF was able to elicit inflammatory response of astrocytes through interaction with CD74 receptor, and activation of ERK was necessary for the intracellular signal transduction. PMID: 27926507
    2. Methylglyoxal induced gene expression of CD74 in the in the diabetic retina. PMID: 24974304
    3. Macrophage migration inhibitory factor(MIF)/CD74 interaction induces upregulation of cyclooxygenase (COX)-2 and prostaglandin E2 secretion in primary rodent microglia. PMID: 21802455
    4. Data indicate that intraluminal macrophage migration inhibitory factor, released from urothelial cells as a consequence of substance P treatment, interacts with urothelial cell-surface CD74. PMID: 19325914
    5. Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat PMID: 19503733

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  • 亞細胞定位：
    [Isoform Long]: Late endosome. Lysosome.; Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome.
  • 數據庫鏈接：


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