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CYREN Antibody, HRP conjugated

  • 中文名稱:
    CYREN兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA883613HB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CYREN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CYREN
  • 別名:
    C7orf49 antibody; Chromosome 7 open reading frame 49 antibody; Modulator of retrovirus infection homolog antibody; MRI antibody; MRI_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cell cycle regulator of non-homologous end joining protein (1-157AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase. Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70. In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination. May also act as an indirect regulator of proteasome.
  • 基因功能參考文獻:
    1. proposition that CYREN is a direct cell-cycle-dependent inhibitor of cNHEJ that promotes error-free repair by homologous recombination during cell cycle phases when sister chromatids are present PMID: 28959974
    2. Interacts with Ku and enhances efficiency of DNA double strand break ligation in vitro PMID: 24610814
    3. Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection. PMID: 17043244
  • 亞細胞定位:
    [Isoform 1]: Cytoplasm. Nucleus. Chromosome.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm. Nucleus.
  • 數據庫鏈接:

    HGNC: 22432

    OMIM: 616980

    KEGG: hsa:78996

    STRING: 9606.ENSP00000376823

    UniGene: Hs.643113



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