在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CYP2U1 Antibody

CYP2U1 Antibody

  • 中文名稱：
    CYP2U1兔多克隆抗體
  • 貨號：
    CSB-PA891357
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HeLa cells and Lovo cells, using Cytochrome P450 2U1 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CYP2U1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CYP2U1
  • 別名：
    CYP2U1; Cytochrome P450 2U1; Long-chain fatty acid omega-monooxygenase
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human Cytochrome P450 2U1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.
  • 基因功能參考文獻：
    1. Most CYP2U1 missense mutations in hereditary spastic paraplegia 56 lead to an inhibition of enzymatic activity that can be explained by the loss of proper heme binding to the protein or modification in protein structure. PMID: 29034544
    2. we report a patient with SPG56 with novel compound heterozygous mutations in CYP2U1 which were identified by whole exome sequencing. Our patient exhibited complex features together with delayed myelination, broadening the phenotypic spectrum of SPG56, and implying that CYP2U1 should be screened in HSP with delayed myelination PMID: 28725025
    3. the mode of interaction of several Fe(III)-heme ligands and substrates with the active site of CYP2U1 on the basis of spectroscopic and molecular docking data.[CYP2U1] PMID: 27456766
    4. protein sequence of CYP2U1 displayed two unique characteristics when compared to those of the human CYPs, the presence of a longer N-terminal region upstream of the putative trans-membrane helix (TMH) containing 8 proline residues, and of an insert of about 20 amino acids containing 5 arginine residues between helices A' and A PMID: 28743672
    5. Cytochrome P450 2U1 (CYP2U1) exhibits several distinctive characteristics among the 57 human CYPs, such as its presence in almost all living organisms with a highly conserved sequence, its particular gene organization with only five exons, its major location in thymus and brain, and its protein sequence involving an unusually long N-terminal region containing 8 proline residues. [review] PMID: 28083596
    6. This is the first formal report of pigmentary degenerative maculopathy associated with a CYP2U1 homozygous mutation PMID: 26914923
    7. we identified two novel mutations in CYP2U1 in two unrelated Hereditary spastic paraplegia patients by whole exome sequencing PMID: 27292318
    8. This is the first report of CYP2E1 and CYP2U1 protein expression in human Amygdala. PMID: 25872594
    9. Data suggest that the 3D model could be useful to identify other substrates of cytochrome P450 2U1 (CYP2U1) and help in understanding its physiologic roles. PMID: 25857771
    10. The CYP2U1 gene shows a low mutation frequency in a general population of complicated hereditary spastic paraparesis PMID: 24337409
    11. human cytochrome P450 2U1 oxidizes endogenous N-arachidonoylserotonin PMID: 24563460
    12. CYP1B1 and CYP2U1 were the only quantifiable CYPs in in freshly isolated human brain microvessels. PMID: 21707071
    13. Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation. PMID: 20630735
    14. CYP2U1 plays an important physiological role in fatty acid signaling processes in both cerebellum and thymus PMID: 14660610

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Spastic paraplegia 56, autosomal recessive (SPG56)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 組織特異性：
    Widely expressed with stronger expression in thymus, heart and cerebellum.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20582

    OMIM: 610670

    KEGG: hsa:113612

    STRING: 9606.ENSP00000333212

    UniGene: Hs.109087



主站蜘蛛池模板： 亚洲精品无码久久久久av老牛| 国产又黄又刺激又高潮的网站| 奇米影视7777久久精品| 日韩精品一区二区在线观看| 精品无码久久久久久久久| 色v99在线影院| 亚洲在av极品无码| 中文字幕 亚洲精品 第1页| 日本少妇毛茸茸高潮| aaaaa少妇高潮大片| 国产v精品成人免费视频| 性av无码天堂vr专区| 欧美搡bbbbb搡bbbbb| 日韩欧美猛交xxxxx无码| 国产成人综合久久久久久| 青草久久人人97超碰| 日产a一a区二区www| 内射白浆一区二区在线观看 | 久久男人av资源站| 色老头精品午夜福利视频| 欧美亚洲精品一区二区 | 国产精品亚洲五月天高清| 亚洲成亚洲成网| 国产真实伦在线观看| 人与禽交videos欧美| 在线视频精品免费观看10| 无码人妻丝袜在线视频红杏| 无套内射在线观看theporn| 伊人情人综合网| 日韩人妻无码制服丝袜视频| 55夜色66夜色国产精品视频 | 亚洲精品嫩草研究院久久| 人妻少妇无码精品视频区| 狼人大香伊蕉国产www亚洲| 国产成人av一区二区三区无码 | 东北老女人高潮大叫对白| 人妻无码熟妇乱又伦精品视频| 大胆欧美熟妇xx| 在线观看国产精品电影| 天天影视网天天综合色| 无码国产成人午夜在线观看|