在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CYP2S1 Antibody

CYP2S1 Antibody

  • 中文名稱：
    CYP2S1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA006432GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CYP2S1
  • 別名：
    CP2S1_HUMAN antibody; CYP2S1 antibody; CYPIIS1 antibody; Cytochrome P450 2S1 antibody; cytochrome P450; family 2; subfamily S; polypeptide 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CYP2S1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage.
  • 基因功能參考文獻(xiàn)：
    1. These results suggest that oxaliplatin exerts its inhibitory effects in human CRC cells via upregulation of CYP2S1 expression in a p53-dependent manner. PMID: 27609465
    2. CYP2S1 regulates colorectal cancer growth through associated with prostaglandin E2-mediated activation of beta-catenin signaling. PMID: 25557876
    3. The P450 2S1 may be involved in the reductive detoxication of several of the activated products of carcinogenic aromatic amines and heterocyclic aromatic amines. PMID: 23682735
    4. NADPH-P450 reductase PMID: 23648403
    5. found that CYP inhibition and siRNA-mediated downregulation of CYP2S1 increased macrophage phagocytosis PMID: 23224081
    6. The reduction in CYP2S1 expression doubled intracellular PGE(2) levels. PMID: 22863683
    7. Data suggest that CYP2S1 is induced in a keratinocyte cell line by exposure to all-trans retinoic acid and ultraviolet B radiation. PMID: 22039172
    8. No association has been found between the CYP2J2 (rs890293, -76G > T) or CYP2S1 (rs34971233, 13106C > T, P466L and rs338583, 13255A > G) gene polymorphisms and respiratory diseases. PMID: 22232929
    9. P450 2S1 can be reduced by NADPH-P450 reductase and suggest normal mixed-function oxidase roles of P450 2S1 to be revealed. PMID: 21430234
    10. identify a novel regulatory cassette that mediates changes in Cyp2s1 expression PMID: 17277313
    11. The presence of a CYP2A-related protein and testosterone metabolism in stellate cell cultures suggest that stellate cells express specific functional isoforms of CYP of which a major form is CYP2S1 PMID: 17280660
    12. identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5 in Japanese individuals PMID: 17495422
    13. 12 genetic variations, which included the two novel nonsynonymous mutations CYP2S1 S61N (0.3%) and CYP2S1 L230R (0.8%), were identified in 50 Korean subjects PMID: 17529885
    14. Review compares the expression of CYP2S1 mRNA and protein in humans, mice and rats, and critically examines evidence pertaining to CYP2S1 regulation and its catalytic activity. PMID: 19368491
    15. CYP2S1 contributes to the metabolism of environmental carcinogens via a nicotinamide adenine dinucleotide phosphate (NADPH)- independent activity. PMID: 19713358

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 組織特異性：
    Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen. Expressed in peripheral blood leukocytes. Constitutively expressed in skin (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15654

    OMIM: 611529

    KEGG: hsa:29785

    STRING: 9606.ENSP00000308032

    UniGene: Hs.98370



主站蜘蛛池模板： 精品国产人妻一区二区三区| 天天弄天天模| 亚洲精品亚洲人成在线| 精品av国产一二三四区| 五十路熟妇亲子交尾| 日本理论片午午伦夜理片2021| 国产在线观看高清视频黄网| 欧美xxxx做受欧美人妖| 国产成人女人在线观看| 男女猛烈无遮挡免费视频 | 亚洲 日韩 国产 中文有码| 亚洲成a人v在线蜜臀| 天堂va欧美ⅴa亚洲va| 人妻丰满熟av无码区hd| 无码精品尤物一区二区三区| 解开人妻的裙子猛烈进入| 国产成人一区二区三区在线观看 | 青青热久免费精品视频| 国产精品久久久| 亚洲乱亚洲乱妇小说网| 亚洲一区二区三区在线播放无码| 久久亚洲精品成人av二次元| 欧美日产欧美日产国产精品| 国产午夜精品久久久久免费视| 少妇性bbb搡bbb爽爽爽欧美| 久久久天堂国产精品女人| 久久精品人人做人人爽老司机| 久久成人伊人欧洲精品| 妺妺窝人体色www聚色窝| 国产suv精品一区二区五| 99久久国产精品免费高潮| 午夜131美女爱做视频| 人妻熟女一区二区aⅴ清水理纱| 无码国产精品一区二区免费i6 | 国产精品毛片无码| 大学生高潮无套内谢视频| 成人无码免费一区二区三区| 综合精品欧美日韩国产在线| 国产高清亚洲精品视bt天堂频| 成人内射国产免费观看| 人人澡超碰碰97碰碰碰|