在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CYP2S1 Antibody

CYP2S1 Antibody

  • 中文名稱：
    CYP2S1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA006432GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CYP2S1
  • 別名：
    CP2S1_HUMAN antibody; CYP2S1 antibody; CYPIIS1 antibody; Cytochrome P450 2S1 antibody; cytochrome P450; family 2; subfamily S; polypeptide 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CYP2S1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage.
  • 基因功能參考文獻(xiàn)：
    1. These results suggest that oxaliplatin exerts its inhibitory effects in human CRC cells via upregulation of CYP2S1 expression in a p53-dependent manner. PMID: 27609465
    2. CYP2S1 regulates colorectal cancer growth through associated with prostaglandin E2-mediated activation of beta-catenin signaling. PMID: 25557876
    3. The P450 2S1 may be involved in the reductive detoxication of several of the activated products of carcinogenic aromatic amines and heterocyclic aromatic amines. PMID: 23682735
    4. NADPH-P450 reductase PMID: 23648403
    5. found that CYP inhibition and siRNA-mediated downregulation of CYP2S1 increased macrophage phagocytosis PMID: 23224081
    6. The reduction in CYP2S1 expression doubled intracellular PGE(2) levels. PMID: 22863683
    7. Data suggest that CYP2S1 is induced in a keratinocyte cell line by exposure to all-trans retinoic acid and ultraviolet B radiation. PMID: 22039172
    8. No association has been found between the CYP2J2 (rs890293, -76G > T) or CYP2S1 (rs34971233, 13106C > T, P466L and rs338583, 13255A > G) gene polymorphisms and respiratory diseases. PMID: 22232929
    9. P450 2S1 can be reduced by NADPH-P450 reductase and suggest normal mixed-function oxidase roles of P450 2S1 to be revealed. PMID: 21430234
    10. identify a novel regulatory cassette that mediates changes in Cyp2s1 expression PMID: 17277313
    11. The presence of a CYP2A-related protein and testosterone metabolism in stellate cell cultures suggest that stellate cells express specific functional isoforms of CYP of which a major form is CYP2S1 PMID: 17280660
    12. identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5 in Japanese individuals PMID: 17495422
    13. 12 genetic variations, which included the two novel nonsynonymous mutations CYP2S1 S61N (0.3%) and CYP2S1 L230R (0.8%), were identified in 50 Korean subjects PMID: 17529885
    14. Review compares the expression of CYP2S1 mRNA and protein in humans, mice and rats, and critically examines evidence pertaining to CYP2S1 regulation and its catalytic activity. PMID: 19368491
    15. CYP2S1 contributes to the metabolism of environmental carcinogens via a nicotinamide adenine dinucleotide phosphate (NADPH)- independent activity. PMID: 19713358

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 組織特異性：
    Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen. Expressed in peripheral blood leukocytes. Constitutively expressed in skin (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15654

    OMIM: 611529

    KEGG: hsa:29785

    STRING: 9606.ENSP00000308032

    UniGene: Hs.98370



主站蜘蛛池模板： 国产精品久久久久av福利动漫| 亚洲人成黄网站69影院| 中文字幕人妻无码一夲道| 少妇av一区二区三区无码| 国产在线一区二区av视频| 国产成人精品无码一区二区三区| 国内精品伊人久久久久网站| 免费无码又爽又高潮视频| 中文字幕无码不卡免费视频| 99久久国产露脸精品| 亚洲一卡2卡3卡4卡5卡乱码观看| 伊人久久大香线蕉av色婷婷色| 男女超爽视频免费播放| 97久久婷婷五月综合色d啪蜜芽 | 久久不见久久见www电影免费| 精品无码国产一区二区三区麻豆| 丝袜人妻一区二区三区| 一区二区三区鲁丝不卡麻豆 | 国产农村黄aaaaa特黄av毛片 | 欧美亚洲日本国产黑白配| 国产播放隔着超薄丝袜进入| 欧美性猛交99久久久久99按摩| 中国国产免费毛卡片| 日韩精品专区在线影院重磅 | av无码小缝喷白浆在线观看| 亚洲处破女av日韩精品波波网| 欧美综合区自拍亚洲综合绿色| 精品免费国产一区二区三区四区| 久久久久久人妻一区精品| 国产午夜精品一区二区三区漫画| 99国产精品欧美一区二区三区| 精品乱码一区二区三区四区| 永久免费的啪啪网站免费观看| 亚洲性夜色噜噜噜在线观看不卡| 日韩乱码人妻无码超清蜜桃| 欧美一性一乱一交一视频| 隔壁人妻被水电工征服| 日本免费一区二区三区视频观看 | 美女张开腿黄网站免费下载| 国产suv精二区| 国产欧美va欧美va香蕉在线|