在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CYP1A2 Antibody

  • 中文名稱:
    CYP1A2兔多克隆抗體
  • 貨號:
    CSB-PA439630
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA439630(CYP1A2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA439630(CYP1A2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human hepatocellular carcinoma tissue, Primary antibody: CSB-PA439630(CYP1A2 Antibody) at dilution 1/440, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CYP1A2
  • 別名:
    Aryl hydrocarbon hydroxylase antibody; CP 12 antibody; CP12 antibody; CP1A2_HUMAN antibody; CYP1A2 antibody; CYPIA2 antibody; Cytochrome P(3)450 antibody; Cytochrome P450 1A2 antibody; Cytochrome P450 4 antibody; Cytochrome P450 family 1 polypeptide 2 antibody; Cytochrome P450 family 1 subfamily A polypeptide 2 antibody; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2 antibody; Cytochrome P450-P3 antibody; Cytochrome P4501A2 antibody; Dioxin inducable P3 450 antibody; Flavoprotein linked monooxygenase antibody; Flavoprotein-linked monooxygenase antibody; Microsomal monooxygenase antibody; P(3)450 antibody; P3 450 antibody; P450 4 antibody; P450 form 4 antibody; P450 P3 antibody; P450(PA) antibody; Xenobiotic monooxygenase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human CYP1A2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation (Probable).
  • 基因功能參考文獻:
    1. The in vitro studies of Pristimerin (PTM) with CYP isoforms indicate that PTM has the potential to cause pharmacokinetic drug interactions with other co-administered drugs metabolized by CYP1A2, 3A4 and 2C9. PMID: 28385095
    2. Phenotyping of CYP 4501A2 Activity by Total Overnight Salivary Caffeine Assessment (TOSCA) in Patients on Warfarin Treatment PMID: 28992765
    3. Both CYP1A2 and CYP2B4 activities were affected by their coexpression in a manner consistent with formation of the high-affinity POR-CYP1A2-CYP2B4 complex. PMID: 29233819
    4. The influence of CYP1A2 genotype in the basal and post-caffeine blood pressure response to caffeine ingestion is modified by physical activity status and caffeine consumption level. PMID: 29522901
    5. The metabolites are predominantly catalyzed by CYP3A4 (77% approximately 87%), with a moderate contribution from CYP3A5 (5% approximately 15%) and CYP1A2 (3.7% approximately 7.5%). PMID: 29247736
    6. the genetic variations of the CYP1A2 gene did not affect the ergogenicity or side effects derived from the consumption of a moderate dose of caffeine. PMID: 29668752
    7. The findings of this study indicate that CYP2C19 contribute to the metabolism of MDMA to MDA in humans PMID: 28117133
    8. a positive association between caffeine intake and abstract reasoning exists in the CC homozygous of the -163C>A polymorphism of CYP1A2 gene. PMID: 29072170
    9. CYP1A2 C164A polymorphism has an interaction with maternal caffeine intake that affects infant birth size in a Japanese cohort study PMID: 28355205
    10. findings provide evidences that miR-320 might inhibit the development of Steroid-induced avascular necrosis of femoral head by targeting CYP1A2. PMID: 29551500
    11. our findings suggest that CYP1A2, CYP3A4 and CYP3A5 play an important role in osteosarcoma tumorigenesis, at primary and metastatic sites, as well in treatment response PMID: 28404946
    12. CYP1A2 rs2470890 was significantly associated with the prognosis of patients with breast cancer and could serve as an independent impact factor of prognosis of breast carcinoma PMID: 28418906
    13. CYP1A2 activity can be monitored using noninvasive random urine samples, and it can be used to assess developmental changes in theophylline clearance by preterm PMID: 27995649
    14. The increased risk of prostate cancer was observed among individuals with the CYP1A2 CA + AA genotype (OR, 1.43; 95% CI, 1.03-2.00). PMID: 29165164
    15. Nerolidol induces endoplasmic reticulum stress and apoptosis in Human HepG2 Cells through extensive CYP2C19 and CYP1A2 mediated drug oxidation. PMID: 28256105
    16. Findings show that at allelic and genotypic level polymorphisms in CYP3A4 and CYP1A2 are significantly associated with a reduced risk of drug addiction in Chinese individuals. PMID: 27257124
    17. Results suggest that CYP4503A4/1A2 phenotyping is unlikely to substitute therapeutic drug monitoring of erlotinib in patients with advanced non-small cell lung cancer. PMID: 28444958
    18. In Silico Predictions of Drug - Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance PMID: 27490388
    19. Study corroborated results from a previous report that described interactions between ADORA2A and CYP1A2 polymorphisms and coffee consumption in Parkinson's disease. PMID: 28135712
    20. CYP1A2 Polymorphisms are associated with lung cancer. PMID: 26987327
    21. The study showed that the CYP1A2 (-163C>A) Rs762551 C/C genotype was associated with an increased risk of age-related macular degeneration. PMID: 28095090
    22. findings suggest that CYP1A2 alleles or haplotypes were not predictive of metabolic phenotypes in the Nigerian population; carriers of CYP2A6*9/*17 genotype are likely to be poor metabolisers of CYP2A6 substrates and may experience adverse reactions or poor efficacy while using drugs metabolised mainly by CYP2A6 PMID: 28231062
    23. frequency of slow activity CYP1A2 enzyme alleles is very low among Emiratis which correlates with the presence of low frequencies of derived alleles in CYP1A2 gene PMID: 28934216
    24. Study provided additional evidence that CYP1A2 is an important susceptibility gene for essential hypertension. PMID: 27977510
    25. the difference in clozapine levels between smokers and nonsmokers appeared to be significant in the individuals carrying the homozygous -163A allele (P=0.02). It was also found that nonsmokers carrying the -163A allele tended to have higher plasma levels of clozapine. Cigarette smoking has a significant impact on the plasma level of clozapine in schizophrenic patients carrying the homozygous -163A allele in the CYP1A2 gen PMID: 27203225
    26. genetic association studies in population in Spain: Data suggest that an SNP in CYP1A2 (-163C>A; rs762551) is not associated with performance enhancement/visual attention effects in response to moderate caffeine consumption as dietary supplement (capsules) during exercise; C-allele carriers reported increased nervousness after caffeine ingestion. PMID: 28287486
    27. We conducted a genome-wide association study (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine ratio. A single SNP at 6p23 (near CD83) and several SNPs at 7p21 (near AHR), 15q24 (near CYP1A2) and 19q13.2 (near CYP2A6) met GW-significance (P < 5 x 10-8) and were associated with one or more metabolites PMID: 27702941
    28. We observed a strong dose-dependent increase in hair PhIP levels. This increase was highly correlated with dose received (rho = 0.68, P < 0.0001).CYP1A2 activity and normalizing for hair melanin did not modify the response to the intervention. PMID: 27207666
    29. findings indicated that the -3860 G > A polymorphism in CYP1A2 might not be a risk factor for lung cancer [meta-analysis] PMID: 27323197
    30. CYP1A2-163C/A polymorphism is associated with increased susceptibility to bladder cancer in the Chinese population. PMID: 27173252
    31. rs762551 AA genotype may lead to higher coffee intake, especially in males, younger age groups, and individuals of Caucasian ethnicity. PMID: 27173183
    32. Combined 3D-QSAR and docking procedures yielded precise information about the common and distinct interactions of inhibitors and the enzyme active sites of CYP1A2. PMID: 26648056
    33. YP1A2 rs762551 was identified as a new potential predictive marker for early breast cancer events in AI-treated breast cancer patients. Moreover, combined genotypes of CYP1A2 rs762551 and CYP19A1 rs4646 or AhR Arg554Lys could further improve prediction of early AI-treatment response PMID: 27029552
    34. The aim of the present study was to screen Uyghur volunteers for CYP1A2 genetic polymorphisms. PMID: 26383175
    35. CYP1A2 -163A/A genotype influence carbamazepine pharmacokinetics. PMID: 26762380
    36. niclosamide was subjected to efficient metabolic reactions hydroxylation and glucuronidation, wherein CYP1A2 and UGT1A1 were the main contributing enzymes, respectively. PMID: 26068521
    37. Pregnane X receptor likely regulates CYP1A2 expression in 3D spheroids of liver cancer cells. PMID: 26643992
    38. The results of this study suggest that the CYP1A2*1F polymorphism is associated with super-refractory schizophrenia. PMID: 26530626
    39. This large meta-analysis suggests no significant effect of the investigated CYP1A2 SNPs on cancer overall risk under various genetic models PMID: 26865042
    40. CYP1A2 rs762551 polymorphism is a protective factor for bladder cancer. PMID: 26514519
    41. CYP rs2470890 allele 'C' showed an association with T2DM only when the interaction with coffee was considered, thereby setting an example of genetic activation by dietary changes associating with metabolic syndrome. PMID: 26588584
    42. CYP1A2 metabolizes E2 to generate the potent anti-tumor agent 2-ME in HCC. PMID: 27093553
    43. For the computed CYP 1A2 binding affinities, the model showed a root mean square error of 4.1 kJ mol-1 and a standard error in prediction in cross-validation of 4.3 kJ mol-1. PMID: 26551865
    44. phenotypic association studies in population in Nigeria: Data suggest polymorphisms in CYP1A2 exist in the population studied; distribution of CYP1A2 activity is bimodal; influence of age/sex on activity are not significant in this biomarker study. PMID: 26098700
    45. Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A2-humanized transgenic mice. PMID: 26582657
    46. The CYP1A2 -3860A genotype was associated with a decreased risk of breast cancer. In contrast, distributions of the -2467T/delT or -2467delT/delT and -163A/C or A/A genotypes among breast cancer patients and controls were similar. PMID: 25921178
    47. Data suggest that short-term fasting up-regulates hepatic expression of CYP1A2 but down-regulates hepatic expression of CYP2C9 as compared with the post-absorptive state; only male subjects were studied. PMID: 25795462
    48. Single-nucleotide polymorphisms alleles near BDNF that were associated with higher coffee consumption. PMID: 25288136
    49. limb-truncal, but not orofacial tardive dyskinesia, is associated with CYP1A2 (-163C>, rs762551) polymorphism PMID: 25602162
    50. Allele frequency of CYP1A2 polymorphisms in the Japanese population PMID: 25552922

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族:
    Cytochrome P450 family
  • 組織特異性:
    Liver.
  • 數據庫鏈接:

    HGNC: 2596

    OMIM: 108330

    KEGG: hsa:1544

    STRING: 9606.ENSP00000342007

    UniGene: Hs.1361



主站蜘蛛池模板: 日本人又黄又爽又色的视频| 欧美叉叉叉bbb网站| 国产精品久久无码一区二区三区网 | 欧美高清在线精品一区| 久久99精品久久久久久齐齐 | 中文字幕一区二区三区乱码| 久久久久九九精品影院| 无码人妻丰满熟妇啪啪网站| 久久精品国产福利一区二区| 久久久久国色av免费看图片| 人澡人人澡人人澡欧美| 国产又粗又硬又大爽黄老大爷视频 | 天天狠天天透天干天干| 国产最新av在线播放不卡| 国产卡1卡2卡3麻豆精品免费 | 国产产区一二三产区区别在线| 亚洲国产精品无码中文字满| 国产精品a久久777777| 国产三级精品三级在线观看| 老熟妇仑乱一区二区视頻| 337人体做爰大胆视频| 日本无码人妻精品一区二区蜜桃 | 99热99这里只有高清国产| 伊人大杳焦在线| 长腿校花无力呻吟娇喘的视频| 国产精品vr专区| 天天澡日日澡狠狠欧美老妇| 人人爽人人澡人人人人妻| 狠狠躁夜夜躁人人躁婷婷视频| 无尺码精品产品日韩| 免费无码又爽又刺激高潮软件| 久久久久人妻一区精品果冻 | 强奷乱码中文字幕熟女导航| 国产国语毛片在线看国产| 先锋影音av资源站av| 久久国产色av免费观看| 色午夜一av男人的天堂| 国产aⅴ爽av久久久久久| 久久精品日韩av无码| 天堂а√中文在线官网| 国产成人亚洲综合无码18禁h|