在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CYFIP1 Antibody

CYFIP1 Antibody

  • 中文名稱：
    CYFIP1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA748722LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of A549 cells with CSB-PA748722LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CYFIP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CY antibody; CYFIP 1 antibody; CYFIP1 antibody; CYFP1_HUMAN antibody; Cytoplasmic FMR1 interacting protein 1 antibody; Cytoplasmic FMR1-interacting protein 1 antibody; FLJ45151 antibody; KIAA0068 antibody; p140sra 1 antibody; p140sra-1 antibody; P140SRA1 antibody; Selective hybridizing clone antibody; SHYC antibody; Specifically Rac1 associated protein 1 antibody; Specifically Rac1-associated protein 1 antibody; SRA 1 antibody; Sra-1 antibody; SRA1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cytoplasmic FMR1-interacting protein 1 protein (320-449AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CYFIP1 Antibody (CSB-PA748722LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于CYFIP1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA748722LB01HU CYFIP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA748722LC01HU CYFIP1 Antibody, FITC conjugated
    Biotin CSB-PA748722LD01HU CYFIP1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. May act as an invasion suppressor in cancers.
  • 基因功能參考文獻(xiàn)：
    1. CYFIP1 gene expression was upregulated in the blood of epileptic patients. PMID: 29992499
    2. The studies suggest that MNK-eiF4E axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1. (Review) PMID: 27527252
    3. rs4778298, a common variant at CYFIP1 is associated with inter-individual variation in surface area across the left supramarginal gyrus. PMID: 27351196
    4. Both mRNA and protein expression levels of Cyfip1 were significantly lower in ALL patients. PMID: 26779626
    5. Reduced CYFIP1 in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks. PMID: 26824476
    6. Hippocampal synapses with reduced Cyfip1 are larger and release neurotransmitter more rapidly. PMID: 26843638
    7. Data confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time PMID: 25311365
    8. This study confirmed that CYFIP2 were altered in postsynaptic density in patient with schizophrenia. PMID: 25048004
    9. haploinsufficiency causes cell polarity defects via WAVE complex destabilization; genetic polymorphism is associated with schizophrenia PMID: 24996170
    10. An imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates risk for autism spectrum disorders. PMID: 24442360
    11. Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the trans-golgi network. PMID: 20228810
    12. located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes PMID: 14508708
    13. CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation PMID: 16260607
    14. quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales PMID: 16982806
    15. Study found that Cyfip1, a subunit of the WAVE complex, which regulates cytoskeletal dynamics, is commonly deleted in human epithelial cancers. PMID: 19524508

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    CYFIP family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13759

    OMIM: 606322

    KEGG: hsa:23191

    STRING: 9606.ENSP00000324549

    UniGene: Hs.26704



主站蜘蛛池模板： 强奷妇系列中文字幕| 亚洲 欧美 天堂 综合| 国产又爽又黄又刺激的视频| 黑人巨大av无码专区| 18禁黄网站禁片免费观看| 激情内射亚洲一区二区三区爱妻| 国产精品久久久久久久久久久久午衣片 | 免费国产高清在线精品一区| 亚洲中文字幕无码一区| 国产99在线 | 中文| а√天堂www在线а√天堂资源| 国模小黎自慰337p人体| 毛片无码国产| 欧美一区二区三区视频在线观看 | 中文字幕无码人妻少妇免费| 亚洲欧洲日产韩国在线看片| 麻豆精品久久久久久中文字幕无码 | 国模小婕私拍鲜嫩玉门| 日本少妇内射视频播放舔| 日韩精品亚洲人成在线观看| 蜜臀av人妻国产精品建身房| 国产揄拍国产精品| 最大胆裸体人体牲交免费| 亚洲成a人片在线观看无码专区| 国产av麻豆mag剧集| 青青青国产在线观看免费| 欧美肥老太交性506070| 久久精品免费一区二区| 久久av无码aⅴ高潮av喷吹| 日韩在线 | 中文| 欧美大胆少妇bbw| 国产一区二区在线影院| 18禁止观看强奷免费国产大片| 国产玉足榨精视频在线观看| 久久精品国产99国产精品导航| 国产精品无打码在线播放| 手机真实国产乱子伦对白视频| 韩国精品一区二区无码视频| 午夜福利理论片高清在线| 久久中文精品无码中文字幕下载| 国产成人免费视频|