在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CYB5R3 Antibody

  • 中文名稱:
    CYB5R3兔多克隆抗體
  • 貨號:
    CSB-PA006320GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    B5R antibody; Cyb5r3 antibody; Cytochrome b5 reductase 3 antibody; Cytochrome b5 reductase antibody; DIA1 antibody; Diaphorase 1 antibody; Diaphorase-1 antibody; NADH cytochrome b5 reductase 3 antibody; NADH-cytochrome b5 reductase 3 membrane-bound form antibody; NADH-cytochrome b5 reductase 3 soluble form antibody; NB5R3_HUMAN antibody; OTTHUMP00000028761 antibody; OTTHUMP00000198435 antibody; OTTHUMP00000198574 antibody; OTTHUMP00000198662 antibody; OTTHUMP00000198665 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CYB5R3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
  • 基因功能參考文獻:
    1. study indicated that novel homozygous mutation p.Arg192Cys in CYB5R3 gene present in eight cases and the possibility of high prevalence of heterozygous in Indian population causing Type I recessive congenital methemoglobinemia. PMID: 29482478
    2. CYB5R3 promotes colonization and metastasis formation and is a prognostic marker of disease-free and overall survival in estrogen receptor-negative breast cancer. PMID: 26351264
    3. Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy. PMID: 25521918
    4. The results unveil a potential mechanism of action by which CYB5R3 deficiency contributes to the pathophysiological underpinnings of neurological disorders in RHM patients. PMID: 24450884
    5. NADH-CYB5R deficiency causes two forms of recessive congenital methemoglobinemia with cyanosis. PMID: 24266649
    6. Dapsone-associated methemoglobinemia in a patient with slow NAT2*5B haplotype and impaired cytochrome b5 reductase activity PMID: 21422237
    7. A comprehensive overview of the study of structure and function of human cytochrome b5 reductase. PMID: 23113554
    8. Data indicate that mitochondrial amidoxime reducing components 1 and 2 together with the electron transport proteins NADH-cytochrome b5 reductase (CYB5R) and cytochrome b5 (CYB5) catalyze the reduction of N-hydroxylated compounds such as amidoximes. PMID: 23703616
    9. Population frequency and age of c.806C > T mutation in CYB5R3 gene as cause of recessive congenital methemoglobinemia in Yakutia. PMID: 23866629
    10. Novel large deletion c.22-1320_633+1224del in the CYB5R3 gene from patients with hereditary methemoglobinemia PMID: 23297489
    11. CYB5R3 gene of three probands with type I methemoglobinemia and their relatives were sequenced revealing several putative causative mutations; in one subject multiple mutations were present PMID: 21349748
    12. We conclude that Cytochrome b(5)and cytochrome b(5) reductase catalyze the reduction of arylhydroxylamines in breast tissue. PMID: 21447608
    13. novel allelic mutation identified at codon 235 is in helix 5; first report of mental retardation because of the novel mutation, along with a second mutation in the NADH-b5R gene in an Indian family with recessive congenital methemoglobinemia Type II PMID: 21328435
    14. Dia1 is localized to the perinuclear endoplasmic reticulum in an RNA-zipcode-independent manner in fibroblasts. PMID: 21266463
    15. It was shown that Yakut patients have none of three missence mutations, Arg57Gln, Leu72Pro, and Val105Met, described in case of this disease in the neighboring populations, Chinese and Japanese, inhabiting the territories south of Yakutia PMID: 12884529
    16. A decrease of the activity of membrane-bound NADH-methemoglobin reductase and a change of physical state of the lipid bilayer of membranes under oxidative stress were found in erythrocytes in vivo and in vitro. PMID: 15039026
    17. Amino acid substitution results in congsenital methemoglobinemia. PMID: 15297856
    18. crystal structure of cytochrome b(5) reductase PMID: 15502298
    19. Recessive congenital methaemoglobinaemia observed in a Lebanese subject with a novel mutation in NADH-cytochrome b5 reductase gene. PMID: 15813912
    20. A novel intronic mutation at 22163 caused markedly reduced mRNA (7% of normal) resulting in type II methemoglobinemia. PMID: 15921385
    21. Dia1 is required for the formation of the actin coat around endosomes downstream of RhoB, connecting membrane trafficking with the regulation of actin dynamics. PMID: 15944396
    22. DIA1 and IQGAP1 interact in cell migration and phagocytic cup formation. PMID: 17620407
    23. report of the clinical and molecular characteristics of 6 new patients with recessive hereditary methemoglobinemia due to cytochrome b5 reductase deficiency; two new mutations of DIA1, c. 82 C>T(Gln27STOP) and c. 136 C>T(Arg45Trp), were found PMID: 18343696
    24. The decline in the activities of G6PD and b5Rm would indicate a decrease in the antioxidant response associated with RBC aging. PMID: 19811411

    顯示更多

    收起更多

  • 相關疾病:
    Methemoglobinemia CYB5R3-related (METHB-CYB5R3)
  • 亞細胞定位:
    [Isoform 1]: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side.; [Isoform 2]: Cytoplasm. Note=Produces the soluble form found in erythrocytes.
  • 蛋白家族:
    Flavoprotein pyridine nucleotide cytochrome reductase family
  • 組織特異性:
    Isoform 2 is expressed at late stages of erythroid maturation.
  • 數據庫鏈接:

    HGNC: 2873

    OMIM: 250800

    KEGG: hsa:1727

    STRING: 9606.ENSP00000354468

    UniGene: Hs.561064



主站蜘蛛池模板: 精品久久久久久无码免费| 天天躁日日躁狠狠躁一区| 国产精品v欧美精品v日韩精品| 国产综合久久久久| 成在人线av无码免费高潮水老板 | 又粗又大又硬毛片免费看| 未满十八勿入av网免费| 午夜性刺激在线视频免费| 亚洲精品www久久久| 国产精品美女久久久久久2018| 国产综合有码无码视频在线| 最近最好的中文字幕2019免费 | 无码丰满熟妇| 狠狠综合亚洲综合亚洲色| 麻豆人妻无码性色av专区| 最近中文av字幕在线中文| 久久99精品久久久久久秒播| 国产福利在线视频蜜芽tv| 国产超碰人人做人人爱| 国产乱子伦一区二区三区=| av在线观看地址| 久久国内精品自在自线| av无码午夜福利一区二区三区| 日韩内射美女人妻一区二区三区| 秋霞国产午夜伦午夜福利片| 天天躁日日躁狠狠久久| 亚洲精品精华液一区二区| 欧美丰满熟妇xxxx性ppx人交| 国产精品一卡二卡三卡| 中国内射xxxx6981少妇| 2020国产在线拍揄自揄视频| 邻居少妇张开双腿让我爽一夜| 国产高清午夜人成在线观看| 国产成人精品日本亚洲999| 久久99国产综合精品| 国产精品久久福利网站| 亚洲性线免费观看视频成熟| 精品无人码麻豆乱码1区2区 | 成人爱做日本视频免费| 永久中文字幕免费视频网站| 国产精品久久久久无码av色戒|