在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CUEDC2 Antibody

CUEDC2 Antibody

  • 中文名稱：
    CUEDC2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA283839
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA283839(CUEDC2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA283839(CUEDC2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human breast infiltrative duct tissue, Human fetal brain tissue, mouse brain tissue, Primary antibody: CSB-PA283839(CUEDC2 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CUEDC2
  • 別名：
    bA18I14.5 antibody; C10orf66 antibody; Chromosome 10 open reading frame 66 antibody; CUE domain containing 2 antibody; CUE domain-containing protein 2 antibody; CUED2 antibody; CUED2_HUMAN antibody; Cuedc2 antibody; MGC2491 antibody; OTTHUMP00000020368 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CUEDC2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:500-1:2000
    IHC 1:100-1:300
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
  • 基因功能參考文獻(xiàn)：
    1. the present study demonstrated that CUEDC2 downregulation prevented DOXinduced cardiotoxicity in H9c2 cells. Therefore, CUEDC2 may be a promising target for the prevention of DOXinduced cardiotoxicity. PMID: 29845245
    2. MicroRNA hsa-miR-324-5p suppresses H5N1 virus replication by targeting the viral PB1 and host CUEDC2. PMID: 30045983
    3. Low CUEDC2 expression is associated with glioma. PMID: 28534933
    4. findings show a correlation between the aberrant expression of CUEDC2, and GLUT3 and LDHA in clinical hepatocellular carcinoma samples, further demonstrating a link between CUEDC2 and the Warburg effect during cancer development PMID: 28325773
    5. Results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome. PMID: 26023733
    6. CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis. PMID: 24882011
    7. High CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment. PMID: 24125838
    8. In response to UV irradiation, CUEDC2 undergoes ERK1/2-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC/C(Cdh1)-mediated cyclin A destruction, cyclin-dependent kinase 2 inactivation, and G1 arrest. PMID: 23776205
    9. a new biological activity for CUEDC2 as the regulator of JAK1/STAT3 signaling and the mechanism by which SOCS3 has been linked to suppression of the JAK/STAT pathway PMID: 22084247
    10. CUEDC2 is a cell-cycle regulator that promotes spindle checkpoint inactivation and releases APC/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 during mitosis. PMID: 21743465
    11. key factor in endocrine resistance in breast cancer PMID: 21572428
    12. These results identify a key post-translational mechanism that controls progesterone receptor protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation. PMID: 17347654

    顯示更多

    收起更多

  • 相關(guān)疾病：
    May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CUEDC2 family
  • 組織特異性：
    Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28352

    OMIM: 614142

    KEGG: hsa:79004

    STRING: 9606.ENSP00000358953

    UniGene: Hs.500874



主站蜘蛛池模板： 三级做爰高清视频| 99国产成人精品视频| 国产精品欧美久久久久无广告| 国产一区二区三区无码免费| 国产精品av免费观看| 国产99视频精品免费视看9| 国产成人av一区二区三区无码 | 久久99精品久久久久久不卡| 又大又硬又黄的免费视频| 色吊丝av中文字幕| 亚洲狠狠成人网| 国内偷窥一区二区三区视频| 无码超乳爆乳中文字幕| 九九热在线视频观看这里只有精品| 国内精品美女视频免费直播| 免费观看男女性高视频| 免费观看黄网站| 另类老妇奶性生bbwbbw| av色国产色拍| 天码人妻一区二区三区| 亚洲国产欧洲综合997久久| 久久精品免视看国产成人明星| 无码午夜福利视频1000集| 性做久久久久久久免费看| 理论片87福利理论电影| 亚洲国产99精品国自产拍| 国产成年女人毛片80s网站| 成人无码免费一区二区三区| 国产精品制服| 无人区一线二线三线乱码| 大白肥妇bbvbbw高潮| 波多野结衣 黑人| 国产日本精品视频在线观看| 国产黑色丝袜在线看片不卡顿| 亚洲色大成网站www| 久久香综合精品久久伊人| www.一区二区三区在线 | 欧洲| 天天躁日日躁狠狠躁视频2021| 日本最新免费二区| 国产亚洲精选美女久久久久| 无码国产精品一区二区免费16|