在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CUEDC2 Antibody

CUEDC2 Antibody

  • 中文名稱：
    CUEDC2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA283839
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA283839(CUEDC2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA283839(CUEDC2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human breast infiltrative duct tissue, Human fetal brain tissue, mouse brain tissue, Primary antibody: CSB-PA283839(CUEDC2 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CUEDC2
  • 別名：
    bA18I14.5 antibody; C10orf66 antibody; Chromosome 10 open reading frame 66 antibody; CUE domain containing 2 antibody; CUE domain-containing protein 2 antibody; CUED2 antibody; CUED2_HUMAN antibody; Cuedc2 antibody; MGC2491 antibody; OTTHUMP00000020368 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CUEDC2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:500-1:2000
    IHC 1:100-1:300
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
  • 基因功能參考文獻(xiàn)：
    1. the present study demonstrated that CUEDC2 downregulation prevented DOXinduced cardiotoxicity in H9c2 cells. Therefore, CUEDC2 may be a promising target for the prevention of DOXinduced cardiotoxicity. PMID: 29845245
    2. MicroRNA hsa-miR-324-5p suppresses H5N1 virus replication by targeting the viral PB1 and host CUEDC2. PMID: 30045983
    3. Low CUEDC2 expression is associated with glioma. PMID: 28534933
    4. findings show a correlation between the aberrant expression of CUEDC2, and GLUT3 and LDHA in clinical hepatocellular carcinoma samples, further demonstrating a link between CUEDC2 and the Warburg effect during cancer development PMID: 28325773
    5. Results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome. PMID: 26023733
    6. CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis. PMID: 24882011
    7. High CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment. PMID: 24125838
    8. In response to UV irradiation, CUEDC2 undergoes ERK1/2-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC/C(Cdh1)-mediated cyclin A destruction, cyclin-dependent kinase 2 inactivation, and G1 arrest. PMID: 23776205
    9. a new biological activity for CUEDC2 as the regulator of JAK1/STAT3 signaling and the mechanism by which SOCS3 has been linked to suppression of the JAK/STAT pathway PMID: 22084247
    10. CUEDC2 is a cell-cycle regulator that promotes spindle checkpoint inactivation and releases APC/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 during mitosis. PMID: 21743465
    11. key factor in endocrine resistance in breast cancer PMID: 21572428
    12. These results identify a key post-translational mechanism that controls progesterone receptor protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation. PMID: 17347654

    顯示更多

    收起更多

  • 相關(guān)疾病：
    May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CUEDC2 family
  • 組織特異性：
    Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28352

    OMIM: 614142

    KEGG: hsa:79004

    STRING: 9606.ENSP00000358953

    UniGene: Hs.500874



主站蜘蛛池模板： 无码高潮喷水在线观看| 国产天堂久久天堂av色综合| 天天爽天天摸天天碰| 1313午夜精品理论片| 国色天香社区视频| 成人欧美一区二区三区的电影| 久久婷婷五月综合色国产香蕉| 爽爽精品dvd蜜桃成熟时电影院| 亚洲人成网站在线播放小说| 成人影院永久免费观看网址| mm1313亚洲国产精品无码试看| av免费不卡国产观看| 国产日韩精品欧美一区喷水 | 吃奶呻吟张开双腿做受在线播放| 日韩人妻无码一区二区三区| 亚洲精品国产熟女久久久| 亚洲中文字幕无码一去台湾| 热99re久久精品这里都是精品免费| 国产成人精品一区二区三区视频| 亚洲高清无在码在线电影不卡| 精品国产一区二区三区国产区| 国产女人水真多18毛片18精品| 欧美人与动性xxxxx杂| 国产精品老熟女露脸视频| 日韩人妻无码精品二专区| 免费观看黄网站| 日本欧美大码a在线观看| 国产精品久久无码不卡黑寡妇| 日韩视频 中文字幕 视频一区| 亚洲人成电影网站色www两男一女| a国产在线v的不卡视频| 无码福利在线观看1000集| 五月婷婷久久草丁香| 成人免费视频一区二区| 久久青青草原国产精品最新片 | 人妻熟妇乱又伦精品hd| 成 年 人 黄 色 大 片大 全| 欧美成人va免费看视频| 久久国产人妻一区二区免费| 国产乱子伦农村xxxx| 久久99精品久久久久久齐齐 |