在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CTR9 Antibody

  • 中文名稱:
    CTR9兔多克隆抗體
  • 貨號(hào):
    CSB-PA006178GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    CTR9
  • 別名:
    Ctr 9 antibody; CTR9 antibody; Ctr9 Paf1/RNA polymerase II complex component; homolog antibody; CTR9; Paf1/RNA polymerase II complex componen antibody; CTR9; S. cerevisiae; homolog of antibody; CTR9_HUMAN antibody; KIAA0155 antibody; p150 antibody; p150(TSP) antibody; p150TSP. antibody; Paf1/RNA polymerase II complex component homolog Ctr9 antibody; RNA polymerase associated protein CTR9 homolog antibody; RNA polymerase-associated protein CTR9 homolog antibody; SH2 binding phosphoprotein antibody; SH2 domain binding protein 1 (tetratricopeptide repeat containing) antibody; SH2 domain binding protein 1 antibody; SH2 domain-binding protein 1 antibody; SH2-binding phosphoprotein of 150 kDa antibody; SH2BP1 antibody; Tetratricopeptide repeat-containing antibody; Tetratricopeptide-containing SH2-binding phosphoprotein 150-KD antibody; TPR containing; SH2-binding phosphoprotein of 150 kDa antibody; TSBP antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CTR9
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3.
  • 基因功能參考文獻(xiàn):
    1. A novel CTR9 germline variant, located in a consensus splice acceptor site, was found to segregate with Wilms tumor in the family. PMID: 29292210
    2. Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha-target gene expression by regulating global chromatin occupancies of ERalpha and RNAPII. PMID: 27829357
    3. Ctr9, a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha(+) breast tumorigenesis PMID: 26494790
    4. Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment. PMID: 26048990
    5. CTR9 is a PAF1 complex gene whose germline mutations predispose to Wilms tumour PMID: 25099282
    6. CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation. PMID: 23593388
    7. MLL interacts directly with the polymerase associated factor complex (PAFc) via Paf1 and CTR9. PAFc augments MLL and MLL-AF9 mediated transcriptional activation of Hoxa9 and their interaction is essential for leukemogenesis. PMID: 20541477
    8. CTR9 participates in the transcription of IL-6-responsive genes through the regulation of DNA association of STAT3 and modification of histone methylation PMID: 17911113

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus speckle.
  • 組織特異性:
    Widely expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16850

    OMIM: 609366

    KEGG: hsa:9646

    STRING: 9606.ENSP00000355013

    UniGene: Hs.725151



主站蜘蛛池模板: 亚洲成av人片在一线观看| 国产又色又刺激高潮视频| 鲁鲁狠狠狠7777一区二区| 国产一区二区三区美女| 风韵丰满熟妇啪啪区老老熟妇 | 99热这里只就有精品22| 国产午夜aaaaa片在线影院| 在线观看国产精品va| 精品一区二区三区无码av久久| 国精产品一品二品国精品69xx| 午夜福利片手机在线播放| 伊人色综合网久久天天| 免费人成视频19674不收费| 一区二区乱子伦在线播放| 无套熟女av呻吟在线观看| 美女扒开腿让男人桶爽app免费看 精品国产免费人成电影在线看 | 2021亚洲国产成a在线| 成人aaa片一区国产精品| 中文字幕v亚洲ⅴv天堂| 国产成人精品久久久久精品日日 | 国产成人高清精品免费| 国产精品18久久久久久欧美| 久久久国产精品黄毛片| 女人大荫蒂毛茸茸视频| 国产voyeur精品偷窥222| 尤物tv国产精品看片在线| 色婷婷亚洲一区二区三区| 国产精品久久久久影院| 国产在线无码视频一区二区三区| 把插八插露脸对白内射| 色依依av在线| 亚洲国产av天码精品果冻传媒| 国产成人精品日本亚洲语音| 国产男女猛烈无遮挡a片漫画| 国产亚洲日韩在线播放更多| 免费国产午夜视频在线观看| 少妇粗大进出白浆嘿嘿视频| 精品国产不卡一区二区三区| 亚洲精品国产一区二区精华| 精品人伦一区二区三电影| 99久久国产宗和精品1上映|