在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CSF2RA Antibody

  • 中文名稱:
    CSF2RA兔多克隆抗體
  • 貨號:
    CSB-PA005243
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of VEC cells using CD116 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD_antigen=CD116 antibody; CD116 antibody; CD116 antigen antibody; CDw116 antibody; Colony stimulating factor 2 receptor alpha chain antibody; Colony stimulating factor 2 receptor alpha low affinity antibody; Colony stimulating factor 2 receptor alpha subunit antibody; CSF 2R antibody; CSF2R antibody; CSF2R_HUMAN antibody; CSF2RA antibody; CSF2RAX antibody; CSF2RAY antibody; CSF2RX antibody; CSF2RY antibody; GM CSF R alpha antibody; GM CSF receptor alpha subunit antibody; GM-CSF-R-alpha antibody; GMCSFR antibody; GMCSFR-alpha antibody; GMR-alpha antibody; Granulocyte macrophage colony stimulating factor receptor alpha chain antibody; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody; SMDP4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human CD116.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
  • 基因功能參考文獻:
    1. Family-based whole genome analysis of a family with hereditary pulmonary alveolar proteinosis revealed a homozygous deletion that disrupts CSF2RA, CRLF2, and IL3RA gene in the pseudoautosomal region of the X chromosome in the affected child and one of asymptomatic siblings. PMID: 28233860
    2. lesions from human secondary progressive multiple sclerosis, but not primary progressive multiple sclerosis patients shows extensive recruitment of GM-CSF Ralpha+ myeloid cells PMID: 28641926
    3. Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. PMID: 27396825
    4. regulatory molecule causative of aortic dissection and intramural haematoma PMID: 25923510
    5. Our cohort broadens the spectrum of knowledge about the clinical variability and genotype-phenotype correlations of juvenile PAP, and illustrates the favorable outcome of WLL treatment in severely affected patients PMID: 25425184
    6. A possible relationship between dysfunction of the granulocyte-macrophage colony stimulating factor receptor, mapping to the pseudoautosomal X-Y region, may exist in myelodysplastic patients with initially lymphocytic Sweet syndrome. PMID: 24714374
    7. Studies indicate the action of GM-CSF can be inhibited by at least two approaches: inhibition by GM-CSF neutralising antibodies, or blockade of GM-CSF binding to its receptor by antibodies against the GM-CSF receptor alpha chain CSF2Ralpha. PMID: 23933508
    8. The GM-CSF Ralpha were ubiquitously but not uniformly expressed in neurons throughout the brain and downregulation in brain in patient with alzheimenr disease. PMID: 22430742
    9. This study reveals a novel functional role of clathrin-coated structure in GMR signaling and the oncogenesis of JAK2V617F. PMID: 22935703
    10. Identify defective expression and function of CD116 as a distinguishing feature of IBD and implicate an associated defect in innate immune responses toward granulocyte-macrophage colony-stimulating factor. PMID: 21557945
    11. The expression rate of GM-CSFR in myelodysplastic syndrome patients was significantly higher than in aplastic anemia patients and controls. PMID: 19099633
    12. 67-kDa laminin receptor expression influenced the characteristics of leukemia cells toward an aggressive phenotype and increased the number of granulocyte-macrophage colony-stimulating factor receptors PMID: 21056082
    13. The cytosolic domain of the hGM Ralpha chain is required for differentiation mediated by activation of the hGM Ralpha, beta(c) receptor complex. PMID: 12384414
    14. soluble forms of the GM-CSF receptor alpha chain and beta chain were produced and a novel mechanism of receptor assembly was demonstrated PMID: 12393492
    15. Constitutive secretion of soluble GMR alpha by monocytes (but not lymphocytes) is up-regulated by GM-CSF and inflammatory mediators in a protein form that represents a mixed population of alternatively spliced and proteolytically cleaved species. PMID: 12421947
    16. Analysis of the 5' promoter of the GM-CSF receptor alpha gene. PMID: 12504125
    17. identified the alpha-chain of the GMCSF receptor as interaction partner of IkappaB kinase beta; direct interaction of IKKbeta and GMRalpha in cells was verified. PMID: 12637324
    18. GM-CSF receptors exhibit different modes of signaling in a factor-dependent bipotential myeloid cell line. PMID: 14504109
    19. used the intracellular portion of the alpha subunit of the GM-CSF receptor to search for interacting proteins and identified the 67-kDa laminin receptor as a binding partner PMID: 14614142
    20. receptors alphaGMR and c-Kit could interact to coordinate their signal initiation; alphaGMR inhibited c-Kit auto-phosphorylation induced by the ligand stem cell factor PMID: 16760463
    21. Sequencing of colony stimulating factor, receptor 2 alpha in an independent case-control cohort revealed both common intronic haplotypes and several novel, rare missense variants associated with schizophrenia. PMID: 17522711
    22. The novel GMRalpha transcript identified herein contains a previously undescribed exon of the GMRalpha gene; this exon derives from an Alu DNA repeat element PMID: 17681666
    23. Results highlight the importance of GM-CSFR expression in monocytes for cytokine-induced myeloid dendritic cells (DC) generation and point to GM-CSF as a direct player in the generation of functionally distinct DC. PMID: 18236400
    24. best diffracting crystals of ternary complex were obtained using the N346Q mutation of the betac subunit. Crystals grew using polyethylene glycol 3350 with a high concentration of proline, belonged to space group P6(3)22 and diffracted to 3.3 A resolution PMID: 18678938
    25. Mutagenesis of the GM-CSF receptor at the dodecamer interface and functional studies reveal that dodecamer formation is required for receptor activation and signaling. PMID: 18692472
    26. Results suggest that that pulmonary alveolar proteinosis can result from a genetic deficiency of the GM-CSF receptor alpha chain, encoded in the X-chromosome pseudoautosomal region 1. PMID: 18955567
    27. These results establish that GM-CSF signaling is critical for surfactant homeostasis in humans and demonstrate that mutations in CSF2RA cause familial PAP. PMID: 18955570

    顯示更多

    收起更多

  • 相關疾病:
    Pulmonary surfactant metabolism dysfunction 4 (SMDP4)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 6]: Secreted.
  • 蛋白家族:
    Type I cytokine receptor family, Type 5 subfamily
  • 數據庫鏈接:

    HGNC: 2435

    OMIM: 300770

    KEGG: hsa:1438

    UniGene: Hs.520937



主站蜘蛛池模板: 男女啪啪进出阳道猛进| 久久精品亚洲精品无码白云tv| 蜜桃视频在线观看免费网址入口| 亚洲人成网亚洲欧洲无码| 玩弄少妇人妻| 欧美日韩精品无码一本二本三本色| 国产清纯美女遭强到高潮| 国产真实伦在线观看| 狠狠色噜噜狠狠狠8888米奇| 国产丝袜足j在线视频播放| 久久精品国产只有精品2020| 毛片内射-百度| 国产爆乳美女娇喘呻吟| 久久久久77777人人人人人| 亚洲精品人成网线在播放va| 国产精品视频一区国模私拍| 亚洲精品一品区二品区三品区| 国内精品久久久久精免费| 真人啪啪高潮喷水呻吟无遮挡| 亚洲丰满熟女一区二区v| 国产99在线 | 亚洲| 国产在线午夜不卡精品影院 | 无码潮喷a片无码高潮视频| 无套内射在线无码播放| 亚洲精品无码久久千人斩| h人成在线看免费视频| 国产日韩成人内射视频| 欧美成人一区二区三区在线视频| 免费人成网视频在线观看| 99精品国产福久久久久久| 无码夜色一区二区三区| 手机看片国产av无码| 国产精品无码a∨麻豆| 国产精品亚洲一区二区三区在线| 日韩 欧美 国产 一区三| 18禁无遮挡羞羞污污污污网站 | 日韩 国产 变态另类 欧美| 精品亚洲卡一卡2卡三卡乱码| 中文无码乱人伦中文视频在线| 少妇一夜三次一区二区| 天堂网在线www资源|